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Article: Bone morphogenetic protein-2, 4, 6 and transforming growth factor-β1 are induced in rat facial nuclei following motoneuron axotomy

TitleBone morphogenetic protein-2, 4, 6 and transforming growth factor-β1 are induced in rat facial nuclei following motoneuron axotomy
Authors
KeywordsBmp
Facial Nerve
Motoneuron
Nerve Regeneration
Tgf-Β1
Issue Date2003
PublisherNihon Soshiki Saibo Kagakukai. The Journal's web site is located at http://www.jstage.jst.go.jp/browse/ahc/_vols/-char/en
Citation
Acta Histochemica Et Cytochemica, 2003, v. 36 n. 3, p. 231-237 How to Cite?
AbstractTransection of the rat facial nerve (FN) leads to a series of retrograde changes within the facial nuclei, which has been called the axon reaction. This reaction includes the rapid activation of both astrocytes and microglia and a change in the gene expression in axotomized motoneurons. In the present study, we investigated the expression of the transforming growth factor-β (TGF-β) superfamily member [bone morphogenetic protein (BMP)-2, 4, 6 and TGF-β1] in the axotomized facial nuclei using in situ hybridization. The aim of the present study was to clarify whether the BMP-2, 4, 6 and TGF-β1 are related to the regenerative and degenerative processes in the axotomized facial nuclei. The results showed that BMP-2 and TGF-β1 mRNA increased gradually after axotomy, and reached the maximal values on day 7 post injury. BMP-6 was expressed abundantly in the facial motoneurons, and no obvious differences were shown in the gene expression after transection of FN. However, no significant signals for BMP-4 in motoneuron were detected at any time point. These results revealed that some members of the TGF-β superfamily such as BMP-2 and TGF-β1, might be involved in glial activation and motoneuron survival, and might be potential neurotrophic factors of FN.
Persistent Identifierhttp://hdl.handle.net/10722/149618
ISSN
2015 Impact Factor: 0.912
2015 SCImago Journal Rankings: 0.589
References

 

DC FieldValueLanguage
dc.contributor.authorJin, Yen_US
dc.contributor.authorSuwa, Fen_US
dc.contributor.authorNie, Xen_US
dc.contributor.authorTipoe, GLen_US
dc.contributor.authorTamada, Yen_US
dc.contributor.authorFang, YRen_US
dc.contributor.authorTanaka, Ten_US
dc.date.accessioned2012-06-26T05:56:06Z-
dc.date.available2012-06-26T05:56:06Z-
dc.date.issued2003en_US
dc.identifier.citationActa Histochemica Et Cytochemica, 2003, v. 36 n. 3, p. 231-237en_US
dc.identifier.issn0044-5991en_US
dc.identifier.urihttp://hdl.handle.net/10722/149618-
dc.description.abstractTransection of the rat facial nerve (FN) leads to a series of retrograde changes within the facial nuclei, which has been called the axon reaction. This reaction includes the rapid activation of both astrocytes and microglia and a change in the gene expression in axotomized motoneurons. In the present study, we investigated the expression of the transforming growth factor-β (TGF-β) superfamily member [bone morphogenetic protein (BMP)-2, 4, 6 and TGF-β1] in the axotomized facial nuclei using in situ hybridization. The aim of the present study was to clarify whether the BMP-2, 4, 6 and TGF-β1 are related to the regenerative and degenerative processes in the axotomized facial nuclei. The results showed that BMP-2 and TGF-β1 mRNA increased gradually after axotomy, and reached the maximal values on day 7 post injury. BMP-6 was expressed abundantly in the facial motoneurons, and no obvious differences were shown in the gene expression after transection of FN. However, no significant signals for BMP-4 in motoneuron were detected at any time point. These results revealed that some members of the TGF-β superfamily such as BMP-2 and TGF-β1, might be involved in glial activation and motoneuron survival, and might be potential neurotrophic factors of FN.en_US
dc.languageengen_US
dc.publisherNihon Soshiki Saibo Kagakukai. The Journal's web site is located at http://www.jstage.jst.go.jp/browse/ahc/_vols/-char/enen_US
dc.relation.ispartofActa Histochemica et Cytochemicaen_US
dc.subjectBmpen_US
dc.subjectFacial Nerveen_US
dc.subjectMotoneuronen_US
dc.subjectNerve Regenerationen_US
dc.subjectTgf-Β1en_US
dc.titleBone morphogenetic protein-2, 4, 6 and transforming growth factor-β1 are induced in rat facial nuclei following motoneuron axotomyen_US
dc.typeArticleen_US
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0041939959en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041939959&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue3en_US
dc.identifier.spage231en_US
dc.identifier.epage237en_US
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridJin, Y=26643271200en_US
dc.identifier.scopusauthoridSuwa, F=6701428537en_US
dc.identifier.scopusauthoridNie, X=7103207433en_US
dc.identifier.scopusauthoridTipoe, GL=7003550610en_US
dc.identifier.scopusauthoridTamada, Y=7005752601en_US
dc.identifier.scopusauthoridFang, YR=7403457335en_US
dc.identifier.scopusauthoridTanaka, T=37085535300en_US

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