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Article: Analysis of the expression of BMP-2,3,4,5 in nerve sheath tumors of maxillofacial region

TitleAnalysis of the expression of BMP-2,3,4,5 in nerve sheath tumors of maxillofacial region
Authors
Issue Date2000
PublisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/
Citation
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 2000, v. 18 n. 5, p. 307-309 How to Cite?
AbstractOBJECTIVE: The aim of present study is to elucidate the relationship between the members of BMP family and the neoplasms of peripheral nerve. METHODS: Eight cases of schwannoma and three cases of malignant schwannoma were collected and all samples were fixed with 10% neutral formalin and embedded in paraffin wax. Five microns thickness sections were prepared for staining with haematoxylin and eosin for histopathological assessment and processed for in situ hybridization for assessing the mRNA transcriptions of BMP-2,3,4,5. Sections of osteosarcoma that previously demonstrated consistent expression of BMP-2 mRNA were included in each batch of staining to serve as positive control. RESULTS: The results showed that all of the neoplastic lesions of nerve sheath showed a consistent expression of BMP-2,3,4,5. The positive signals of benign lesions were obviously increased in the palisading area or the area of accumulated cells. There was no detectable staining in the matrix of tumour and collagenous fiber. The staining intensity was relatively and slightly weak in cells of Antoni B tissue when compared with Antoni A tissue. Nevertheless, the tumour cells in Antoni B tissue also showed BMP-2,3,4 and 5 positively staining. The fibroblasts of schwannoma were negatively stained. The malignant lesions showed higher expression signals of BMPs than benign lesions. CONCLUSION: The results can be concluded that the selected members of BMPs may be involved in the process of growth and progression of the neoplasms of peripheral nerve.
Persistent Identifierhttp://hdl.handle.net/10722/149615
ISSN
2015 SCImago Journal Rankings: 0.121

 

DC FieldValueLanguage
dc.contributor.authorJin, Yen_US
dc.contributor.authorLu, Hen_US
dc.contributor.authorTipoe, GLen_US
dc.contributor.authorLi, Yen_US
dc.date.accessioned2012-06-26T05:56:04Z-
dc.date.available2012-06-26T05:56:04Z-
dc.date.issued2000en_US
dc.identifier.citationHua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 2000, v. 18 n. 5, p. 307-309en_US
dc.identifier.issn1000-1182en_US
dc.identifier.urihttp://hdl.handle.net/10722/149615-
dc.description.abstractOBJECTIVE: The aim of present study is to elucidate the relationship between the members of BMP family and the neoplasms of peripheral nerve. METHODS: Eight cases of schwannoma and three cases of malignant schwannoma were collected and all samples were fixed with 10% neutral formalin and embedded in paraffin wax. Five microns thickness sections were prepared for staining with haematoxylin and eosin for histopathological assessment and processed for in situ hybridization for assessing the mRNA transcriptions of BMP-2,3,4,5. Sections of osteosarcoma that previously demonstrated consistent expression of BMP-2 mRNA were included in each batch of staining to serve as positive control. RESULTS: The results showed that all of the neoplastic lesions of nerve sheath showed a consistent expression of BMP-2,3,4,5. The positive signals of benign lesions were obviously increased in the palisading area or the area of accumulated cells. There was no detectable staining in the matrix of tumour and collagenous fiber. The staining intensity was relatively and slightly weak in cells of Antoni B tissue when compared with Antoni A tissue. Nevertheless, the tumour cells in Antoni B tissue also showed BMP-2,3,4 and 5 positively staining. The fibroblasts of schwannoma were negatively stained. The malignant lesions showed higher expression signals of BMPs than benign lesions. CONCLUSION: The results can be concluded that the selected members of BMPs may be involved in the process of growth and progression of the neoplasms of peripheral nerve.en_US
dc.languageengen_US
dc.publisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/en_US
dc.relation.ispartofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBone Morphogenetic Proteins - Biosynthesisen_US
dc.subject.meshFacial Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshJaw Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNerve Sheath Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshNeurilemmoma - Metabolism - Pathologyen_US
dc.titleAnalysis of the expression of BMP-2,3,4,5 in nerve sheath tumors of maxillofacial regionen_US
dc.typeArticleen_US
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12539647-
dc.identifier.scopuseid_2-s2.0-0038390550en_US
dc.identifier.hkuros63787-
dc.identifier.volume18en_US
dc.identifier.issue5en_US
dc.identifier.spage307en_US
dc.identifier.epage309en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridJin, Y=26643271200en_US
dc.identifier.scopusauthoridLu, H=7404843896en_US
dc.identifier.scopusauthoridTipoe, GL=7003550610en_US
dc.identifier.scopusauthoridLi, Y=36064605300en_US

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