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Article: Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimer's disease

TitlePhosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimer's disease
Authors
Issue Date2002
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2002, v. 13 n. 18, p. 2429-2432 How to Cite?
AbstractInhibition of protein translation is a mode of inducing neuronal apoptosis and neurodegeneration in Alzheimer's disease (AD). Phosphorylation of eukaryotic initiation factor-2α (eIF2α) terminates global protein translation and induces apoptosis. We examined whether this signaling pathway occurs in degenerating neurons of AD. Brain sections from young individuals, age-matched control individuals and AD patients were examined for immunoreactivity of phosphorylated eIF2α by immunohistochemical analysis. While young brain sections did not display and age-matched brain sections have mild immunoreactive positive cells, AD brain sections revealed intense immunoreactivity for phosphorylated eIF2α. Most of the phosphorylated eIF2α immunoreactive positive neurons have high immunoreactivity for phosphorylated tau using AT8 antibody. Also, intense staining of phosphorylated eIF2α is associated vacuoles in degenerating neurons. This phenomenon was also observed for the immunohistochemical staining of phosphorylated PKR (double-stranded RNA-dependent protein kinase), the upstream kinase for eIF2α. Activation of PKR-eIF2α pathway is considered to be pro-apoptotic. In addition, formation of autophagy is regulated by eIF2α kinase. Therefore, it is concluded that phosphorylation of eIF2α is associated with the degeneration of neurons in AD. © 2002 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/149611
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, RCCen_US
dc.contributor.authorWong, AKYen_US
dc.contributor.authorNg, HKen_US
dc.contributor.authorHugon, Jen_US
dc.date.accessioned2012-06-26T05:55:57Z-
dc.date.available2012-06-26T05:55:57Z-
dc.date.issued2002en_US
dc.identifier.citationNeuroreport, 2002, v. 13 n. 18, p. 2429-2432en_US
dc.identifier.issn0959-4965en_US
dc.identifier.urihttp://hdl.handle.net/10722/149611-
dc.description.abstractInhibition of protein translation is a mode of inducing neuronal apoptosis and neurodegeneration in Alzheimer's disease (AD). Phosphorylation of eukaryotic initiation factor-2α (eIF2α) terminates global protein translation and induces apoptosis. We examined whether this signaling pathway occurs in degenerating neurons of AD. Brain sections from young individuals, age-matched control individuals and AD patients were examined for immunoreactivity of phosphorylated eIF2α by immunohistochemical analysis. While young brain sections did not display and age-matched brain sections have mild immunoreactive positive cells, AD brain sections revealed intense immunoreactivity for phosphorylated eIF2α. Most of the phosphorylated eIF2α immunoreactive positive neurons have high immunoreactivity for phosphorylated tau using AT8 antibody. Also, intense staining of phosphorylated eIF2α is associated vacuoles in degenerating neurons. This phenomenon was also observed for the immunohistochemical staining of phosphorylated PKR (double-stranded RNA-dependent protein kinase), the upstream kinase for eIF2α. Activation of PKR-eIF2α pathway is considered to be pro-apoptotic. In addition, formation of autophagy is regulated by eIF2α kinase. Therefore, it is concluded that phosphorylation of eIF2α is associated with the degeneration of neurons in AD. © 2002 Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_US
dc.relation.ispartofNeuroReporten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAlzheimer Disease - Metabolism - Pathologyen_US
dc.subject.meshEukaryotic Initiation Factor-2 - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshFluorescent Dyesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve Degeneration - Metabolism - Pathologyen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshSignal Transductionen_US
dc.titlePhosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00001756-200212200-00011en_US
dc.identifier.pmid12499843-
dc.identifier.scopuseid_2-s2.0-0037147666en_US
dc.identifier.hkuros78454-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037147666&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue18en_US
dc.identifier.spage2429en_US
dc.identifier.epage2432en_US
dc.identifier.isiWOS:000180673200011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChang, RCC=7403713410en_US
dc.identifier.scopusauthoridWong, AKY=7403147402en_US
dc.identifier.scopusauthoridNg, HK=7401619354en_US
dc.identifier.scopusauthoridHugon, J=7103202992en_US

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