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Article: Down-regulation of Id-1 expression is associated with TGFβ1-induced growth arrest in prostate epithelial cells

TitleDown-regulation of Id-1 expression is associated with TGFβ1-induced growth arrest in prostate epithelial cells
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbagen
Citation
Biochimica Et Biophysica Acta - General Subjects, 2002, v. 1570 n. 3, p. 145-152 How to Cite?
AbstractTransforming growth factor β1 (TGFβ1) plays important roles in the regulation of cell growth and differentiation in both normal and malignant prostate epithelial cells. Although certain pathways have been suggested, the mechanisms responsible for the action of TGFβ1 are not well understood. In the present study, using a human papilloma virus 16 E6/E7 immortalized prostate epithelial cell line, HPr-1, we report that TGFβ1 was able to suppress the expression of Id-1, a helix-loop-helix (HLH) protein, which plays important roles in the inhibition of cell differentiation and growth arrest. In addition, a decrease at both Id-1 mRNA and protein expression levels was associated with TGFβ1-induced growth arrest and differentiation, indicating that Id-1 may be involved in TGFβ1 signaling pathway. The fact that up-regulation of p21WAF1, one of the downstream effectors of Id-1, was observed after exposure to TGFβ1 further indicates the involvement of Id-1 in the TGFβ1-induced growth arrest in HPr-1 cells. However, increased expression of p27KIP1 was also observed in the TGFβ1-treated cells, suggesting that in addition to down-regulation of Id-1, other factors may be involved in the TGFβ1-induced cell growth arrest and differentiation in prostate epithelial cells. Our results provide evidence for the first time that TGFβ1 may be one of the upstream regulators of Id-1. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149609
ISSN
2015 Impact Factor: 5.083
2015 SCImago Journal Rankings: 2.128
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLing, MTen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorWong, YCen_US
dc.date.accessioned2012-06-26T05:55:56Z-
dc.date.available2012-06-26T05:55:56Z-
dc.date.issued2002en_US
dc.identifier.citationBiochimica Et Biophysica Acta - General Subjects, 2002, v. 1570 n. 3, p. 145-152en_US
dc.identifier.issn0304-4165en_US
dc.identifier.urihttp://hdl.handle.net/10722/149609-
dc.description.abstractTransforming growth factor β1 (TGFβ1) plays important roles in the regulation of cell growth and differentiation in both normal and malignant prostate epithelial cells. Although certain pathways have been suggested, the mechanisms responsible for the action of TGFβ1 are not well understood. In the present study, using a human papilloma virus 16 E6/E7 immortalized prostate epithelial cell line, HPr-1, we report that TGFβ1 was able to suppress the expression of Id-1, a helix-loop-helix (HLH) protein, which plays important roles in the inhibition of cell differentiation and growth arrest. In addition, a decrease at both Id-1 mRNA and protein expression levels was associated with TGFβ1-induced growth arrest and differentiation, indicating that Id-1 may be involved in TGFβ1 signaling pathway. The fact that up-regulation of p21WAF1, one of the downstream effectors of Id-1, was observed after exposure to TGFβ1 further indicates the involvement of Id-1 in the TGFβ1-induced growth arrest in HPr-1 cells. However, increased expression of p27KIP1 was also observed in the TGFβ1-treated cells, suggesting that in addition to down-regulation of Id-1, other factors may be involved in the TGFβ1-induced cell growth arrest and differentiation in prostate epithelial cells. Our results provide evidence for the first time that TGFβ1 may be one of the upstream regulators of Id-1. © 2002 Elsevier Science B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbagenen_US
dc.relation.ispartofBiochimica et Biophysica Acta - General Subjectsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCell Cycle Proteins - Biosynthesisen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCyclin-Dependent Kinase Inhibitor P21en_US
dc.subject.meshCyclin-Dependent Kinase Inhibitor P27en_US
dc.subject.meshCyclins - Biosynthesisen_US
dc.subject.meshDna-Binding Proteins - Biosynthesis - Physiologyen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshEpithelial Cells - Metabolismen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHelix-Loop-Helix Motifs - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibitor Of Differentiation Protein 1en_US
dc.subject.meshMaleen_US
dc.subject.meshProstate - Metabolismen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshReceptors, Transforming Growth Factor Beta - Metabolismen_US
dc.subject.meshRepressor Proteinsen_US
dc.subject.meshTranscription Factors - Biosynthesis - Physiologyen_US
dc.subject.meshTransforming Growth Factor Beta - Physiologyen_US
dc.subject.meshTransforming Growth Factor Beta1en_US
dc.subject.meshTumor Suppressor Proteins - Biosynthesisen_US
dc.subject.meshUp-Regulationen_US
dc.titleDown-regulation of Id-1 expression is associated with TGFβ1-induced growth arrest in prostate epithelial cellsen_US
dc.typeArticleen_US
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityLing, MT=rp00449en_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-4165(02)00189-7en_US
dc.identifier.pmid12020803-
dc.identifier.scopuseid_2-s2.0-0037089442en_US
dc.identifier.hkuros67234-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037089442&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1570en_US
dc.identifier.issue3en_US
dc.identifier.spage145en_US
dc.identifier.epage152en_US
dc.identifier.isiWOS:000176018300001-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLing, MT=7102229780en_US
dc.identifier.scopusauthoridWang, X=7501854829en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US

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