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Article: Overexpression of matrix metalloproteinase-8 and -9 in bronchiectatic airways in vivo

TitleOverexpression of matrix metalloproteinase-8 and -9 in bronchiectatic airways in vivo
Authors
KeywordsBronchial Biopsy
Bronchiectasis
Matrix Metalloproteinase
Neutrophils
Issue Date2002
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2002, v. 20 n. 1, p. 170-176 How to Cite?
AbstractThe progressive bronchial dilatation in bronchiectasis is likely to be the result of continued airway matrix destruction, although little is known about the role of neutrophil matrix metalloproteinases (MMPs) in this process. Immunohistochemistry has been used to investigate the expression and cellular localisation of MMP-8 and MMP-9 in bronchiectatic airways in vivo. Endobronchial biopsies were taken from 25 bronchiectatic patients, and from the right lower lobe in 14 control subjects. MMP-8, MMP-9, neutrophils and macrophages were stained with monoclonal antibodies and quantified as positive cell·mm -2 of the lamina propria by using an image analysis system. There were significantly higher densities of MMP-8 and MMP-9 positive cells in the lamina propria of bronchiectatic than control airways. In bronchiectatic airways, the densities of MMP-8 and MMP-9 positive cells correlated with each other and with neutrophil density, but not with macrophage density. In control airways, a significant correlation was found between MMP-8 with neutrophil and MMP-9 with macrophage densities. An overexpression of neutrophil matrix metalloproteinases in bronchiectatic airways could help explain the continuation of airway destruction in bronchiectasis. In view of the clinical availability of matrix metalloproteinase antagonists, the results presented here could have a significant impact on the development of novel therapies of this untreatable disease.
Persistent Identifierhttp://hdl.handle.net/10722/149605
ISSN
2014 Impact Factor: 7.636
2014 SCImago Journal Rankings: 2.855
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Len_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorTipoe, GLen_US
dc.contributor.authorShum, IHen_US
dc.contributor.authorYan, Cen_US
dc.contributor.authorLeung, Ren_US
dc.contributor.authorSun, Jen_US
dc.contributor.authorOoi, GCen_US
dc.contributor.authorTsang, KWen_US
dc.date.accessioned2012-06-26T05:55:51Z-
dc.date.available2012-06-26T05:55:51Z-
dc.date.issued2002en_US
dc.identifier.citationEuropean Respiratory Journal, 2002, v. 20 n. 1, p. 170-176en_US
dc.identifier.issn0903-1936en_US
dc.identifier.urihttp://hdl.handle.net/10722/149605-
dc.description.abstractThe progressive bronchial dilatation in bronchiectasis is likely to be the result of continued airway matrix destruction, although little is known about the role of neutrophil matrix metalloproteinases (MMPs) in this process. Immunohistochemistry has been used to investigate the expression and cellular localisation of MMP-8 and MMP-9 in bronchiectatic airways in vivo. Endobronchial biopsies were taken from 25 bronchiectatic patients, and from the right lower lobe in 14 control subjects. MMP-8, MMP-9, neutrophils and macrophages were stained with monoclonal antibodies and quantified as positive cell·mm -2 of the lamina propria by using an image analysis system. There were significantly higher densities of MMP-8 and MMP-9 positive cells in the lamina propria of bronchiectatic than control airways. In bronchiectatic airways, the densities of MMP-8 and MMP-9 positive cells correlated with each other and with neutrophil density, but not with macrophage density. In control airways, a significant correlation was found between MMP-8 with neutrophil and MMP-9 with macrophage densities. An overexpression of neutrophil matrix metalloproteinases in bronchiectatic airways could help explain the continuation of airway destruction in bronchiectasis. In view of the clinical availability of matrix metalloproteinase antagonists, the results presented here could have a significant impact on the development of novel therapies of this untreatable disease.en_US
dc.languageengen_US
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_US
dc.relation.ispartofEuropean Respiratory Journalen_US
dc.subjectBronchial Biopsyen_US
dc.subjectBronchiectasisen_US
dc.subjectMatrix Metalloproteinaseen_US
dc.subjectNeutrophilsen_US
dc.titleOverexpression of matrix metalloproteinase-8 and -9 in bronchiectatic airways in vivoen_US
dc.typeArticleen_US
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1183/09031936.02.00282402en_US
dc.identifier.pmid12166566-
dc.identifier.scopuseid_2-s2.0-0035989381en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035989381&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.spage170en_US
dc.identifier.epage176en_US
dc.identifier.isiWOS:000177188600028-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridZheng, L=7403404086en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridTipoe, GL=7003550610en_US
dc.identifier.scopusauthoridShum, IH=6602960338en_US
dc.identifier.scopusauthoridYan, C=8728540500en_US
dc.identifier.scopusauthoridLeung, R=7101876102en_US
dc.identifier.scopusauthoridSun, J=7410371598en_US
dc.identifier.scopusauthoridOoi, GC=7006176119en_US
dc.identifier.scopusauthoridTsang, KW=7201555024en_US

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