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Article: Study of the role of the low-affinity neurotrophin receptor p75 in naturally occurring cell death during development of the rat retina

TitleStudy of the role of the low-affinity neurotrophin receptor p75 in naturally occurring cell death during development of the rat retina
Authors
Issue Date2001
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DNE
Citation
Developmental Neuroscience, 2001, v. 23 n. 6, p. 390-398 How to Cite?
AbstractThe aim of this study was to examine the tempo-spatial expression of low-affinity neurotrophin receptor p75, or p75 NTR, and its role in the induction of retinal ganglion cell (RGC) apoptosis in the rat retina during development. The cellular distribution of p75 in the retina was demonstrated with immunohistochemistry and double-immunofluorescent staining. Apoptosis in the developing rat retina was detected by DNA gel electrophoresis, and the number of RGCs undergoing apoptosis was estimated by terminal deoxyribonucleotidyl-mediated dUTP-digoxigenin nick end labeling (TUNEL). To localize p75 on apoptotic RGCs, p75 immunofluorescence and TUNEL fluorescent staining was performed on sections with Fluoro-Gold-prelabeled RGCs. p75 immunoreactivities were not detected either on the RGCs or TUNEL-positive cells, whereas Müller cell processes were p75 immunopositive. Thus, it was most unlikely that p75 induced apoptosis of RGCs in the rat retina. Copyright © 2002 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/149602
ISSN
2015 Impact Factor: 2.898
2015 SCImago Journal Rankings: 1.484
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDing, Jen_US
dc.contributor.authorHu, Ben_US
dc.contributor.authorTang, LSen_US
dc.contributor.authorYip, HKen_US
dc.date.accessioned2012-06-26T05:55:48Z-
dc.date.available2012-06-26T05:55:48Z-
dc.date.issued2001en_US
dc.identifier.citationDevelopmental Neuroscience, 2001, v. 23 n. 6, p. 390-398en_US
dc.identifier.issn0378-5866en_US
dc.identifier.urihttp://hdl.handle.net/10722/149602-
dc.description.abstractThe aim of this study was to examine the tempo-spatial expression of low-affinity neurotrophin receptor p75, or p75 NTR, and its role in the induction of retinal ganglion cell (RGC) apoptosis in the rat retina during development. The cellular distribution of p75 in the retina was demonstrated with immunohistochemistry and double-immunofluorescent staining. Apoptosis in the developing rat retina was detected by DNA gel electrophoresis, and the number of RGCs undergoing apoptosis was estimated by terminal deoxyribonucleotidyl-mediated dUTP-digoxigenin nick end labeling (TUNEL). To localize p75 on apoptotic RGCs, p75 immunofluorescence and TUNEL fluorescent staining was performed on sections with Fluoro-Gold-prelabeled RGCs. p75 immunoreactivities were not detected either on the RGCs or TUNEL-positive cells, whereas Müller cell processes were p75 immunopositive. Thus, it was most unlikely that p75 induced apoptosis of RGCs in the rat retina. Copyright © 2002 S. Karger AG, Basel.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DNEen_US
dc.relation.ispartofDevelopmental Neuroscienceen_US
dc.subject.meshAging - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshApoptosis - Physiologyen_US
dc.subject.meshDna - Metabolismen_US
dc.subject.meshDna Fragmentation - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetusen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshFluorescent Dyes - Diagnostic Useen_US
dc.subject.meshGene Expression Regulation, Developmental - Physiologyen_US
dc.subject.meshIn Situ Nick-End Labeling - Methodsen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptor, Nerve Growth Factor - Genetics - Metabolismen_US
dc.subject.meshRetina - Embryology - Growth & Development - Metabolismen_US
dc.subject.meshRetinal Ganglion Cells - Cytology - Metabolismen_US
dc.subject.meshStilbamidinesen_US
dc.titleStudy of the role of the low-affinity neurotrophin receptor p75 in naturally occurring cell death during development of the rat retinaen_US
dc.typeArticleen_US
dc.identifier.emailYip, HK:hkfyip@hku.hken_US
dc.identifier.authorityYip, HK=rp00285en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000048725en_US
dc.identifier.pmid11872939-
dc.identifier.scopuseid_2-s2.0-0035724898en_US
dc.identifier.hkuros74762-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035724898&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.spage390en_US
dc.identifier.epage398en_US
dc.identifier.isiWOS:000174360100002-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridDing, J=8573831500en_US
dc.identifier.scopusauthoridHu, B=35733928400en_US
dc.identifier.scopusauthoridTang, LS=7402081562en_US
dc.identifier.scopusauthoridYip, HK=7101980864en_US

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