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Article: Overexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epithelium

TitleOverexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epithelium
Authors
Issue Date2001
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 2001, v. 37 n. 3, p. 225-233 How to Cite?
AbstractThe aim of the present study was to determine the relationships between bone morphogenetic proteins (BMPs), BMP receptor type IA and carcinogenesis of oral epithelium. A retrospective study was performed on material obtained from oral mucosa, including nine cases of normal mucosa (NB), eight cases of nonspecific chronic inflammation (NCI), seven cases of hyperkeratosis (HK), five cases of squamous cell papilloma (SCP), 29 cases of squamous cell carcinoma (SCC) with various grades of differentiation and 10 cases of epithelium adjacent to carcinoma (EAC). Six cases of NB from hard palate (NHP) were chosen as a control group. The benign groups consisted of NCI, HK and SCP. The antibodies against BMP-2/4, -5, receptor BMPR-IA and purified bovine BMP (bBMP-McAb) were utilised using an immunocytochemical method. The results demonstrated that the immunostaining of BMP-2/4, BMP-5, BMPR-IA and bBMP-McAb was weak and not consistent in normal and benign groups. The immunoreactivity level was independent of the clinical and pathological grading of SCC. All cases of SCC showed positive staining for BMP-2/4, BMP-5, BMPR-IA and bBMP-McAb except for three cases and one case of SCC which negatively stained for BMP-2/4 and BMP-5, respectively. The staining intensity and proportion of the positively stained cells were markedly increased in SCC when compared with that of the normal and benign groups except for EAC. The metastatic carcinoma cells in lymph nodes were strongly and positively stained for BMP-2/4 and BMP-5 when compared with the primary lesions. Our results indicate that there was an overexpression of BMP-2/4, BMP-5, bBMP-McAb and BMPR-IA in the high-risk premalignant and malignant lesions of oral epithelium. Our findings suggest that BMP-2/4 and BMP-5 but not BMPR-IA might be involved in the metastasis of oral carcinoma cells. © 2001 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/149600
ISSN
2015 Impact Factor: 4.286
2015 SCImago Journal Rankings: 1.764
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, Yen_US
dc.contributor.authorTipoe, GLen_US
dc.contributor.authorLiong, ECen_US
dc.contributor.authorLau, TYHen_US
dc.contributor.authorFung, PCWen_US
dc.contributor.authorLeung, KMen_US
dc.date.accessioned2012-06-26T05:55:47Z-
dc.date.available2012-06-26T05:55:47Z-
dc.date.issued2001en_US
dc.identifier.citationOral Oncology, 2001, v. 37 n. 3, p. 225-233en_US
dc.identifier.issn1368-8375en_US
dc.identifier.urihttp://hdl.handle.net/10722/149600-
dc.description.abstractThe aim of the present study was to determine the relationships between bone morphogenetic proteins (BMPs), BMP receptor type IA and carcinogenesis of oral epithelium. A retrospective study was performed on material obtained from oral mucosa, including nine cases of normal mucosa (NB), eight cases of nonspecific chronic inflammation (NCI), seven cases of hyperkeratosis (HK), five cases of squamous cell papilloma (SCP), 29 cases of squamous cell carcinoma (SCC) with various grades of differentiation and 10 cases of epithelium adjacent to carcinoma (EAC). Six cases of NB from hard palate (NHP) were chosen as a control group. The benign groups consisted of NCI, HK and SCP. The antibodies against BMP-2/4, -5, receptor BMPR-IA and purified bovine BMP (bBMP-McAb) were utilised using an immunocytochemical method. The results demonstrated that the immunostaining of BMP-2/4, BMP-5, BMPR-IA and bBMP-McAb was weak and not consistent in normal and benign groups. The immunoreactivity level was independent of the clinical and pathological grading of SCC. All cases of SCC showed positive staining for BMP-2/4, BMP-5, BMPR-IA and bBMP-McAb except for three cases and one case of SCC which negatively stained for BMP-2/4 and BMP-5, respectively. The staining intensity and proportion of the positively stained cells were markedly increased in SCC when compared with that of the normal and benign groups except for EAC. The metastatic carcinoma cells in lymph nodes were strongly and positively stained for BMP-2/4 and BMP-5 when compared with the primary lesions. Our results indicate that there was an overexpression of BMP-2/4, BMP-5, bBMP-McAb and BMPR-IA in the high-risk premalignant and malignant lesions of oral epithelium. Our findings suggest that BMP-2/4 and BMP-5 but not BMPR-IA might be involved in the metastasis of oral carcinoma cells. © 2001 Elsevier Science Ltd.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncologyen_US
dc.relation.ispartofOral Oncologyen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshBone Morphogenetic Protein 2en_US
dc.subject.meshBone Morphogenetic Protein 5en_US
dc.subject.meshBone Morphogenetic Protein Receptors, Type Ien_US
dc.subject.meshBone Morphogenetic Proteins - Analysisen_US
dc.subject.meshCarcinoma, Squamous Cell - Metabolismen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCell Membrane - Chemistryen_US
dc.subject.meshCytoplasm - Chemistryen_US
dc.subject.meshEpithelium - Chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLeukoplakia, Oral - Geneticsen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMouth Mucosa - Chemistryen_US
dc.subject.meshMouth Neoplasms - Metabolismen_US
dc.subject.meshNeoplasm Proteins - Analysisen_US
dc.subject.meshPalateen_US
dc.subject.meshPapilloma - Geneticsen_US
dc.subject.meshPrecancerous Conditions - Metabolismen_US
dc.subject.meshProtein-Serine-Threonine Kinases - Analysisen_US
dc.subject.meshReceptors, Growth Factor - Analysisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTransforming Growth Factor Betaen_US
dc.titleOverexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epitheliumen_US
dc.typeArticleen_US
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1368-8375(00)00087-7en_US
dc.identifier.pmid11287276-
dc.identifier.scopuseid_2-s2.0-0035088024en_US
dc.identifier.hkuros63848-
dc.identifier.hkuros60342-
dc.identifier.hkuros73967-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035088024&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume37en_US
dc.identifier.issue3en_US
dc.identifier.spage225en_US
dc.identifier.epage233en_US
dc.identifier.isiWOS:000168218100005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridJin, Y=26643271200en_US
dc.identifier.scopusauthoridTipoe, GL=7003550610en_US
dc.identifier.scopusauthoridLiong, EC=6602732210en_US
dc.identifier.scopusauthoridLau, TYH=26323763000en_US
dc.identifier.scopusauthoridFung, PCW=7101613315en_US
dc.identifier.scopusauthoridLeung, KM=7401860685en_US

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