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Article: Macrophages, neutrophils and tumour necrosis factor-α expression in bronchiectatic airways in vivo

TitleMacrophages, neutrophils and tumour necrosis factor-α expression in bronchiectatic airways in vivo
Authors
Issue Date2001
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 2001, v. 95 n. 10, p. 792-798 How to Cite?
AbstractBronchiectasis is increasingly being recognized as an inflammatory condition of the airways in which pathological permanent dilation occurs. We have obtained endobronchial biopsies in 14 patients with stable bronchiectasis and 15 control subjects. Airway neutrophils, macrophages and tumour necrosis factor-α (TNFα)-positive cells were stained with monoclonal antibodies and the densities of positive cells in the lamina propria were determined by using a computer image analyser. There was significantly higher neutrophil, macrophage and TNFα-positive cell densities in the lamina propria of bronchiectatic than control airways (P<0·001, P<0·001 and P=0·0002, respectively). Airway neutrophil density, in bronchiectasis but not in controls, correlated with TNFα-positive cell density (r=0·71, P=0·004). A significant correlation between airway macrophage and TNFα-positive cell densities was demonstrated in both control and bronchiectatic airways (r=0·63, P=0·016 and r=0·60, P=0·02 respectively). Neutrophil density negatively correlated with per cent forced vital capacity (FVC%) predicted among patients with bronchiectasis (r=-0·53, P=0·04). Bronchiectasis patients who were regular sputum producers had a significantly higher macrophage, but not neutrophil density, than their counterparts (P=0·02 and P=0·48 respectively). Our original findings suggest that airway macrophages could contribute to neutrophil influx into airway walls through their production of TNFα and therefore play an important role in the pathogenesis of bronchiectasis. © 2001 Harcourt Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/149598
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.396
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Len_US
dc.contributor.authorShum, IHen_US
dc.contributor.authorTipoe, GLen_US
dc.contributor.authorLeung, Ren_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorOoi, GCen_US
dc.contributor.authorTsang, KWen_US
dc.date.accessioned2012-06-26T05:55:45Z-
dc.date.available2012-06-26T05:55:45Z-
dc.date.issued2001en_US
dc.identifier.citationRespiratory Medicine, 2001, v. 95 n. 10, p. 792-798en_US
dc.identifier.issn0954-6111en_US
dc.identifier.urihttp://hdl.handle.net/10722/149598-
dc.description.abstractBronchiectasis is increasingly being recognized as an inflammatory condition of the airways in which pathological permanent dilation occurs. We have obtained endobronchial biopsies in 14 patients with stable bronchiectasis and 15 control subjects. Airway neutrophils, macrophages and tumour necrosis factor-α (TNFα)-positive cells were stained with monoclonal antibodies and the densities of positive cells in the lamina propria were determined by using a computer image analyser. There was significantly higher neutrophil, macrophage and TNFα-positive cell densities in the lamina propria of bronchiectatic than control airways (P<0·001, P<0·001 and P=0·0002, respectively). Airway neutrophil density, in bronchiectasis but not in controls, correlated with TNFα-positive cell density (r=0·71, P=0·004). A significant correlation between airway macrophage and TNFα-positive cell densities was demonstrated in both control and bronchiectatic airways (r=0·63, P=0·016 and r=0·60, P=0·02 respectively). Neutrophil density negatively correlated with per cent forced vital capacity (FVC%) predicted among patients with bronchiectasis (r=-0·53, P=0·04). Bronchiectasis patients who were regular sputum producers had a significantly higher macrophage, but not neutrophil density, than their counterparts (P=0·02 and P=0·48 respectively). Our original findings suggest that airway macrophages could contribute to neutrophil influx into airway walls through their production of TNFα and therefore play an important role in the pathogenesis of bronchiectasis. © 2001 Harcourt Publishers Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, Cd - Analysisen_US
dc.subject.meshAntigens, Differentiation, Myelomonocytic - Analysisen_US
dc.subject.meshBiological Markers - Analysisen_US
dc.subject.meshBronchiectasis - Immunology - Pathologyen_US
dc.subject.meshBronchoscopyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCell Counten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLung - Immunology - Pathologyen_US
dc.subject.meshMacrophages - Metabolism - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeutrophils - Metabolism - Pathologyen_US
dc.subject.meshPancreatic Elastase - Analysisen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTumor Necrosis Factor-Alpha - Metabolismen_US
dc.titleMacrophages, neutrophils and tumour necrosis factor-α expression in bronchiectatic airways in vivoen_US
dc.typeArticleen_US
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/rmed.2001.1155en_US
dc.identifier.pmid11601743-
dc.identifier.scopuseid_2-s2.0-0034764130en_US
dc.identifier.hkuros68134-
dc.identifier.hkuros64250-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034764130&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume95en_US
dc.identifier.issue10en_US
dc.identifier.spage792en_US
dc.identifier.epage798en_US
dc.identifier.isiWOS:000171557600004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZheng, L=7403404086en_US
dc.identifier.scopusauthoridShum, IH=6602960338en_US
dc.identifier.scopusauthoridTipoe, GL=7003550610en_US
dc.identifier.scopusauthoridLeung, R=7101876102en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridOoi, GC=7006176119en_US
dc.identifier.scopusauthoridTsang, KW=7201555024en_US

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