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Article: A comparative study of the clinicopathological significance of E-cadherin and catenins (α, β, γ) expression in the surgical management of oral tongue carcinoma

TitleA comparative study of the clinicopathological significance of E-cadherin and catenins (α, β, γ) expression in the surgical management of oral tongue carcinoma
Authors
KeywordsCarcinoma
Catenin
E-cadherin
Oral
Tongue
Issue Date2001
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00432/index.htm
Citation
Journal Of Cancer Research And Clinical Oncology, 2001, v. 127 n. 1, p. 59-63 How to Cite?
AbstractPurpose: E-cadherin and catenins are important epithelial adhesion molecules in normal epithelium. Loss of E-cadherin-catenin adhesion is an important step in the progression of many epithelial cancers. E-cadherin and catenins expression in carcinoma of the tongue were evaluated in relation to their clinicopathological features and prognostic values. Method: Immunohistochemical staining was carried out with E-cadherin and (α, β, γ)-catenin monoclonal antibodies for 85 surgical specimens of oral tongue carcinoma, nine matched metastatic lymph nodes, and seven locally recurrent tumours. Results: There was under-expression in 85% of E-cadherin, 94% of α-catenin, 89% of β-catenin, and 83% of γ-catenin in the primary tumours. There was no correlation of E-cadherin/catenin expression with sex, age, cancer stage, and differentiation. Nodal metastasis was found in 68% of patients with weak expression of γ-catenin compared with 9% with strong expression in primary tumours (chi-square, P = 0.02). E-cadherin was a significant prognostic factor for survival and recurrence; patients with weak E-cadherin expression had 53% 5-year survival compared with 85% with strong expression (Wilcoxon, P = 0.0159). Conclusions: Both E-cadherin and catenins were highly under-expressed in oral tongue carcinoma, metastatic lymph node, and recurrent tumour. γ-catenin had predictive value for nodal metastasis. E-cadherin was, however, a more important prognostic factor for recurrence and survival.
Persistent Identifierhttp://hdl.handle.net/10722/149597
ISSN
2015 Impact Factor: 3.141
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, Ven_HK
dc.contributor.authorWing Yuen, APen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorWah Tsao, GSen_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2012-06-26T05:55:43Z-
dc.date.available2012-06-26T05:55:43Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Cancer Research And Clinical Oncology, 2001, v. 127 n. 1, p. 59-63en_HK
dc.identifier.issn0171-5216en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149597-
dc.description.abstractPurpose: E-cadherin and catenins are important epithelial adhesion molecules in normal epithelium. Loss of E-cadherin-catenin adhesion is an important step in the progression of many epithelial cancers. E-cadherin and catenins expression in carcinoma of the tongue were evaluated in relation to their clinicopathological features and prognostic values. Method: Immunohistochemical staining was carried out with E-cadherin and (α, β, γ)-catenin monoclonal antibodies for 85 surgical specimens of oral tongue carcinoma, nine matched metastatic lymph nodes, and seven locally recurrent tumours. Results: There was under-expression in 85% of E-cadherin, 94% of α-catenin, 89% of β-catenin, and 83% of γ-catenin in the primary tumours. There was no correlation of E-cadherin/catenin expression with sex, age, cancer stage, and differentiation. Nodal metastasis was found in 68% of patients with weak expression of γ-catenin compared with 9% with strong expression in primary tumours (chi-square, P = 0.02). E-cadherin was a significant prognostic factor for survival and recurrence; patients with weak E-cadherin expression had 53% 5-year survival compared with 85% with strong expression (Wilcoxon, P = 0.0159). Conclusions: Both E-cadherin and catenins were highly under-expressed in oral tongue carcinoma, metastatic lymph node, and recurrent tumour. γ-catenin had predictive value for nodal metastasis. E-cadherin was, however, a more important prognostic factor for recurrence and survival.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00432/index.htmen_HK
dc.relation.ispartofJournal of Cancer Research and Clinical Oncologyen_HK
dc.subjectCarcinomaen_HK
dc.subjectCateninen_HK
dc.subjectE-cadherinen_HK
dc.subjectOralen_HK
dc.subjectTongueen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCadherins - Biosynthesisen_US
dc.subject.meshCarcinoma - Diagnosis - Metabolism - Mortalityen_US
dc.subject.meshCytoskeletal Proteins - Biosynthesisen_US
dc.subject.meshDesmoplakinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHead And Neck Neoplasms - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrognosisen_US
dc.subject.meshTongue Neoplasms - Diagnosis - Metabolism - Mortalityen_US
dc.subject.meshTrans-Activatorsen_US
dc.subject.meshAlpha Cateninen_US
dc.subject.meshBeta Cateninen_US
dc.subject.meshGamma Cateninen_US
dc.titleA comparative study of the clinicopathological significance of E-cadherin and catenins (α, β, γ) expression in the surgical management of oral tongue carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailWah Tsao, GS: gswtsao@hkucc.hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWah Tsao, GS=rp00399en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s004320000177en_HK
dc.identifier.pmid11206273-
dc.identifier.scopuseid_2-s2.0-0034744325en_HK
dc.identifier.hkuros56511-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034744325&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume127en_HK
dc.identifier.issue1en_HK
dc.identifier.spage59en_HK
dc.identifier.epage63en_HK
dc.identifier.isiWOS:000166508100009-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChow, V=7006616213en_HK
dc.identifier.scopusauthoridWing Yuen, AP=15824563100en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridWah Tsao, GS=7102813116en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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