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Article: Survival of motor neurons and expression of β-amyloid protein in the aged rat spinal cord

TitleSurvival of motor neurons and expression of β-amyloid protein in the aged rat spinal cord
Authors
Issue Date2000
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2000, v. 11 n. 4, p. 697-700 How to Cite?
AbstractThe present study investigated expression of β-amyloid protein (AP) and Amyloid precursor protein (APP) in spinal motor neurons of young adult (3 month old) and aged (26-30 month old) rats. The total number of spinal motor neurons in the seventh cervical (C7) spinal segment was also examined in both young adult and aged rats. There was an ~21% (p < 0.001) decrease in the number of motor neurons of the C7 spinal segment in aged rats compared with young ones. Immunoreactivity (IR) of AP and APP was not observed in spinal motor neurons of young adult rats. In contrast, ~50% of the spinal motor neurons of the aged rats were APP positive. Furthermore, extensive immunoreactivity was found in the processes of spinal motor neurons of aged rats. These results have shown that AP and APP is coincident with the loss of motor neurons in the spinal cord of aged rats, and might be associated with the degenerative processes of ageing motor neurons. (C) 2000 Lippincott Williams and Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/149595
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXie, YYen_US
dc.contributor.authorYao, ZBen_US
dc.contributor.authorWu, WTen_US
dc.date.accessioned2012-06-26T05:55:42Z-
dc.date.available2012-06-26T05:55:42Z-
dc.date.issued2000en_US
dc.identifier.citationNeuroreport, 2000, v. 11 n. 4, p. 697-700en_US
dc.identifier.issn0959-4965en_US
dc.identifier.urihttp://hdl.handle.net/10722/149595-
dc.description.abstractThe present study investigated expression of β-amyloid protein (AP) and Amyloid precursor protein (APP) in spinal motor neurons of young adult (3 month old) and aged (26-30 month old) rats. The total number of spinal motor neurons in the seventh cervical (C7) spinal segment was also examined in both young adult and aged rats. There was an ~21% (p < 0.001) decrease in the number of motor neurons of the C7 spinal segment in aged rats compared with young ones. Immunoreactivity (IR) of AP and APP was not observed in spinal motor neurons of young adult rats. In contrast, ~50% of the spinal motor neurons of the aged rats were APP positive. Furthermore, extensive immunoreactivity was found in the processes of spinal motor neurons of aged rats. These results have shown that AP and APP is coincident with the loss of motor neurons in the spinal cord of aged rats, and might be associated with the degenerative processes of ageing motor neurons. (C) 2000 Lippincott Williams and Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_US
dc.relation.ispartofNeuroReporten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAging - Metabolismen_US
dc.subject.meshAmyloid Beta-Peptides - Analysisen_US
dc.subject.meshAmyloid Beta-Protein Precursor - Analysisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Counten_US
dc.subject.meshCell Deathen_US
dc.subject.meshCell Survival - Physiologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Neurons - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord - Metabolismen_US
dc.titleSurvival of motor neurons and expression of β-amyloid protein in the aged rat spinal corden_US
dc.typeArticleen_US
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, WT=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10757503-
dc.identifier.scopuseid_2-s2.0-0034689702en_US
dc.identifier.hkuros51522-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034689702&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue4en_US
dc.identifier.spage697en_US
dc.identifier.epage700en_US
dc.identifier.isiWOS:000086083200014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXie, YY=7403958873en_US
dc.identifier.scopusauthoridYao, ZB=7401467890en_US
dc.identifier.scopusauthoridWu, WT=7407081122en_US

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