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Article: Effects of neurotrophic factors on motoneuron survival following axonal injury in newborn rats

TitleEffects of neurotrophic factors on motoneuron survival following axonal injury in newborn rats
Authors
Issue Date2000
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2000, v. 11 n. 10, p. 2237-2241 How to Cite?
AbstractUsing two different lesion models, the spinal root avulsion and the distal nerve axotomy, the present study investigated effects of known neurotrophic factors on motoneuron survival in newborn rats. Results of the present study show that 100% of motoneurons in the lesioned spinal segment die at I week following root avulsion, and more than 80% of them die at 2 weeks following distal nerve axotomy. Local application of GDNF can rescue 92% of motoneurons up to 1 week from degeneration due to root avulsion and almost 100% of them up to 2 weeks from degeneration due to distal nerve axotomy. Local application of BDNF fails to prevent any motoneuron death in newborn rats following root avulsion, but it can rescue about 50% of motoneurons up to 2 weeks from degeneration due to distal nerve axotomy. CNTF and IGF-1 fail to prevent any motoneuron death following either distal nerve axotomy or root avulsion. Thus, comparing all the neurotrophic factors tested in this study, GDNF is most effective in preventing death of motoneurons following axonal injury in newborn rats. (C) 2000 Lippincott Williams and Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/149594
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorCheung, ALMen_US
dc.contributor.authorPrevette, DMen_US
dc.contributor.authorOppenheim, RWen_US
dc.date.accessioned2012-06-26T05:55:41Z-
dc.date.available2012-06-26T05:55:41Z-
dc.date.issued2000en_US
dc.identifier.citationNeuroreport, 2000, v. 11 n. 10, p. 2237-2241en_US
dc.identifier.issn0959-4965en_US
dc.identifier.urihttp://hdl.handle.net/10722/149594-
dc.description.abstractUsing two different lesion models, the spinal root avulsion and the distal nerve axotomy, the present study investigated effects of known neurotrophic factors on motoneuron survival in newborn rats. Results of the present study show that 100% of motoneurons in the lesioned spinal segment die at I week following root avulsion, and more than 80% of them die at 2 weeks following distal nerve axotomy. Local application of GDNF can rescue 92% of motoneurons up to 1 week from degeneration due to root avulsion and almost 100% of them up to 2 weeks from degeneration due to distal nerve axotomy. Local application of BDNF fails to prevent any motoneuron death in newborn rats following root avulsion, but it can rescue about 50% of motoneurons up to 2 weeks from degeneration due to distal nerve axotomy. CNTF and IGF-1 fail to prevent any motoneuron death following either distal nerve axotomy or root avulsion. Thus, comparing all the neurotrophic factors tested in this study, GDNF is most effective in preventing death of motoneurons following axonal injury in newborn rats. (C) 2000 Lippincott Williams and Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_US
dc.relation.ispartofNeuroReporten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshAxons - Physiologyen_US
dc.subject.meshAxotomyen_US
dc.subject.meshCell Deathen_US
dc.subject.meshCell Survival - Physiologyen_US
dc.subject.meshLaminectomyen_US
dc.subject.meshMotor Neurons - Cytology - Pathology - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshSpinal Cord - Pathology - Physiopathologyen_US
dc.subject.meshSpinal Cord Injuries - Pathology - Physiopathologyen_US
dc.subject.meshSpinal Nerve Roots - Injuriesen_US
dc.titleEffects of neurotrophic factors on motoneuron survival following axonal injury in newborn ratsen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.emailCheung, ALM:lmcheung@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityCheung, ALM=rp00332en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10923678-
dc.identifier.scopuseid_2-s2.0-0034647622en_US
dc.identifier.hkuros51868-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034647622&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue10en_US
dc.identifier.spage2237en_US
dc.identifier.epage2241en_US
dc.identifier.isiWOS:000088282700035-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYuan, Q=7202814773en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridCheung, ALM=7401806497en_US
dc.identifier.scopusauthoridPrevette, DM=7003628635en_US
dc.identifier.scopusauthoridOppenheim, RW=7102628195en_US

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