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Article: Axonal regeneration of retinal ganglion cells: Effect of trophic factors

TitleAxonal regeneration of retinal ganglion cells: Effect of trophic factors
Authors
Issue Date2000
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/preteyeres
Citation
Progress In Retinal And Eye Research, 2000, v. 19 n. 5, p. 559-575 How to Cite?
AbstractA variety of neurotrophic factors can influence the cell functions of the developing, mature and injured retinal ganglion cells. The discovery that retinal ganglion cell loss can be alleviated by neurotrophic factors has generated a great deal of interest in the therapeutic potential of these molecules. Recently, evidence has provided valuable information on the receptors that mediate these events and the intracellular signaling cascades after the binding of these ligands. Signaling by neurotrophic factors does not seem to restrict to retrograde messenger from the target but also includes local interactions with neighbouring cells along the axonal pathways, anterograde signaling from the afferents and autocrine signaling. More insight into the mechanisms of action of neurotrophic factors and the signal transduction pathway leading to the protection and regeneration of retinal ganglion cells may allow the design of new therapeutic strategies. Copyright (C) 2000 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/149593
ISSN
2015 Impact Factor: 9.394
2015 SCImago Journal Rankings: 5.073
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYip, HKen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2012-06-26T05:55:41Z-
dc.date.available2012-06-26T05:55:41Z-
dc.date.issued2000en_US
dc.identifier.citationProgress In Retinal And Eye Research, 2000, v. 19 n. 5, p. 559-575en_US
dc.identifier.issn1350-9462en_US
dc.identifier.urihttp://hdl.handle.net/10722/149593-
dc.description.abstractA variety of neurotrophic factors can influence the cell functions of the developing, mature and injured retinal ganglion cells. The discovery that retinal ganglion cell loss can be alleviated by neurotrophic factors has generated a great deal of interest in the therapeutic potential of these molecules. Recently, evidence has provided valuable information on the receptors that mediate these events and the intracellular signaling cascades after the binding of these ligands. Signaling by neurotrophic factors does not seem to restrict to retrograde messenger from the target but also includes local interactions with neighbouring cells along the axonal pathways, anterograde signaling from the afferents and autocrine signaling. More insight into the mechanisms of action of neurotrophic factors and the signal transduction pathway leading to the protection and regeneration of retinal ganglion cells may allow the design of new therapeutic strategies. Copyright (C) 2000 Elsevier Science Ltd.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/preteyeresen_US
dc.relation.ispartofProgress in Retinal and Eye Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxons - Physiologyen_US
dc.subject.meshAxotomyen_US
dc.subject.meshCell Transplantationen_US
dc.subject.meshNerve Growth Factors - Physiologyen_US
dc.subject.meshNerve Regeneration - Physiologyen_US
dc.subject.meshPeripheral Nerves - Cytologyen_US
dc.subject.meshRetinal Ganglion Cells - Physiologyen_US
dc.subject.meshVitreous Body - Physiologyen_US
dc.titleAxonal regeneration of retinal ganglion cells: Effect of trophic factorsen_US
dc.typeArticleen_US
dc.identifier.emailYip, HK:hkfyip@hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityYip, HK=rp00285en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1350-9462(00)00009-4en_US
dc.identifier.pmid10925243-
dc.identifier.scopuseid_2-s2.0-0034285194en_US
dc.identifier.hkuros52395-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034285194&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.spage559en_US
dc.identifier.epage575en_US
dc.identifier.isiWOS:000088611700003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYip, HK=7101980864en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US

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