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Article: Additive effect of NOS inhibitor and neurotrophic factors on the survival of injured Clarke's neurons

TitleAdditive effect of NOS inhibitor and neurotrophic factors on the survival of injured Clarke's neurons
Authors
Issue Date1999
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 1999, v. 10 n. 12, p. 2569-2573 How to Cite?
AbstractThe present study examined the effect of treatment with the NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) together with peripheral nerve (PN) graft or brain-derived neurotrophic factor (BDNF) on the survival of CN neurons at the L1 level of the spinal cord following hemisection at T11. In control animals 41% of CN neurons survived 15 days after the hemisection, and 48% of these expressed NOS. Treatment with either PN graft implantation or continuous infusion of BDNF increased the survival rate of CN neurons to 70%; 70% of these expressed NOS. Combined L.-NAME and PN graft or L-NAME and BDNF improved the rescue rate up to 94%, but only 33% expressed NOS. Our results suggest that the expression of NOS, might adversely influence the neuroprotective function of neurotrophic factors on injured CN neurons in the spinal cord.
Persistent Identifierhttp://hdl.handle.net/10722/149582
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References
Errata

 

DC FieldValueLanguage
dc.contributor.authorYick, LWen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2012-06-26T05:55:33Z-
dc.date.available2012-06-26T05:55:33Z-
dc.date.issued1999en_US
dc.identifier.citationNeuroreport, 1999, v. 10 n. 12, p. 2569-2573en_US
dc.identifier.issn0959-4965en_US
dc.identifier.urihttp://hdl.handle.net/10722/149582-
dc.description.abstractThe present study examined the effect of treatment with the NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) together with peripheral nerve (PN) graft or brain-derived neurotrophic factor (BDNF) on the survival of CN neurons at the L1 level of the spinal cord following hemisection at T11. In control animals 41% of CN neurons survived 15 days after the hemisection, and 48% of these expressed NOS. Treatment with either PN graft implantation or continuous infusion of BDNF increased the survival rate of CN neurons to 70%; 70% of these expressed NOS. Combined L.-NAME and PN graft or L-NAME and BDNF improved the rescue rate up to 94%, but only 33% expressed NOS. Our results suggest that the expression of NOS, might adversely influence the neuroprotective function of neurotrophic factors on injured CN neurons in the spinal cord.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_US
dc.relation.ispartofNeuroReporten_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain-Derived Neurotrophic Factor - Pharmacologyen_US
dc.subject.meshCell Survival - Drug Effectsen_US
dc.subject.meshEnzyme Inhibitors - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshNg-Nitroarginine Methyl Ester - Pharmacologyen_US
dc.subject.meshNeurons - Drug Effects - Pathologyen_US
dc.subject.meshNeuroprotective Agents - Pharmacologyen_US
dc.subject.meshNitric Oxide Synthase - Antagonists & Inhibitorsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleAdditive effect of NOS inhibitor and neurotrophic factors on the survival of injured Clarke's neuronsen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10574371-
dc.identifier.scopuseid_2-s2.0-0033588410en_US
dc.identifier.hkuros47005-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033588410&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue12en_US
dc.identifier.spage2569en_US
dc.identifier.epage2573en_US
dc.identifier.isiWOS:000082116100025-
dc.publisher.placeUnited Statesen_US
dc.relation.erratumeid:eid_2-s2.0-11344256495-
dc.identifier.scopusauthoridYick, LW=6603414804en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US

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