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Article: Downregulation and abnormal expression of e-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis

TitleDownregulation and abnormal expression of e-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis
Authors
Issue Date1999
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1999, v. 30 n. 4, p. 458-466 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is predominantly of the undifferentiated histological subtype. Histological differentiation is of limited prognostic significance in NPC. Recent studies have suggested that downregulation of the cadherin-catenin cell adhesion complex may play a crucial role in the initial stage of cancer invasion and metastasis and is associated with poor prognosis in human cancers. Expression of E-cadherin has not been reported previously in NPC, and its prognostic value in NPC is unknown. The purpose of this study was to examine the expression pattern of E-cadherin and its associated partner, β-catenin, in NPC and their possible applications as prognostic markers to predict the clinical outcome of NPC. Expression of the E-cadherin and β-catenin was examined by immunohistochemical methods in 74 cases of primary NPC and 17 of their corresponding lymph node metastases. Normal nasopharyngeal epithelium showed strong and homogeneous immunocytochemical staining of E-cadherin and β-catenin at the cell membranes and intercellular junctions. In contrast, primary NPC showed variable and heterogeneous staining patterns of E-cadherin and β-catenin. Loss of membranous E-cadherin expression was significantly associated with advanced stages of diseases (P < .001). Eighty percent to ninety percent of NPC in stages IV and V (Ho's staging), respectively, showed a reduced (<35%) membranous staining of E- cadherin compared with normal nasopharyngeal epithelium. Expression of β- catenin also was downregulated in advanced NPC. Ninety percent to one hundred percent of NPC in stages IV and V (Ho's staging) expressed a reduction (<35%) of immunocytochemical staining of β-catenin. The expression pattern of β- catenin staining was strongly associated with the expression of E-cadherin (P < .001). Unlike E-cadherin, nuclear staining of β-catenin expression was observed in some of the primary NPC and lymph node metastasis. Reduced expression of E-cadherin and β-catenin expression was associated with a shorter survival of NPC patients (P < .001). In advanced NPC patients (stages IV and V), a significant difference in survival was observed in tumors with higher or lower levels of E-cadherin expression (P = .0224, log-rank test). These observations suggests that expression of E-cadherin and β-catenin may have prognostic values in NPC patients.
Persistent Identifierhttp://hdl.handle.net/10722/149578
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Zen_US
dc.contributor.authorPan, Jen_US
dc.contributor.authorChu, Ben_US
dc.contributor.authorWong, YCen_US
dc.contributor.authorCheung, ALMen_US
dc.contributor.authorTsao, SWen_US
dc.date.accessioned2012-06-26T05:55:29Z-
dc.date.available2012-06-26T05:55:29Z-
dc.date.issued1999en_US
dc.identifier.citationHuman Pathology, 1999, v. 30 n. 4, p. 458-466en_US
dc.identifier.issn0046-8177en_US
dc.identifier.urihttp://hdl.handle.net/10722/149578-
dc.description.abstractNasopharyngeal carcinoma (NPC) is predominantly of the undifferentiated histological subtype. Histological differentiation is of limited prognostic significance in NPC. Recent studies have suggested that downregulation of the cadherin-catenin cell adhesion complex may play a crucial role in the initial stage of cancer invasion and metastasis and is associated with poor prognosis in human cancers. Expression of E-cadherin has not been reported previously in NPC, and its prognostic value in NPC is unknown. The purpose of this study was to examine the expression pattern of E-cadherin and its associated partner, β-catenin, in NPC and their possible applications as prognostic markers to predict the clinical outcome of NPC. Expression of the E-cadherin and β-catenin was examined by immunohistochemical methods in 74 cases of primary NPC and 17 of their corresponding lymph node metastases. Normal nasopharyngeal epithelium showed strong and homogeneous immunocytochemical staining of E-cadherin and β-catenin at the cell membranes and intercellular junctions. In contrast, primary NPC showed variable and heterogeneous staining patterns of E-cadherin and β-catenin. Loss of membranous E-cadherin expression was significantly associated with advanced stages of diseases (P < .001). Eighty percent to ninety percent of NPC in stages IV and V (Ho's staging), respectively, showed a reduced (<35%) membranous staining of E- cadherin compared with normal nasopharyngeal epithelium. Expression of β- catenin also was downregulated in advanced NPC. Ninety percent to one hundred percent of NPC in stages IV and V (Ho's staging) expressed a reduction (<35%) of immunocytochemical staining of β-catenin. The expression pattern of β- catenin staining was strongly associated with the expression of E-cadherin (P < .001). Unlike E-cadherin, nuclear staining of β-catenin expression was observed in some of the primary NPC and lymph node metastasis. Reduced expression of E-cadherin and β-catenin expression was associated with a shorter survival of NPC patients (P < .001). In advanced NPC patients (stages IV and V), a significant difference in survival was observed in tumors with higher or lower levels of E-cadherin expression (P = .0224, log-rank test). These observations suggests that expression of E-cadherin and β-catenin may have prognostic values in NPC patients.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_US
dc.relation.ispartofHuman Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshCadherins - Biosynthesisen_US
dc.subject.meshCarcinoma - Metabolism - Mortality - Pathologyen_US
dc.subject.meshCytoskeletal Proteins - Biosynthesisen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymph Nodes - Metabolismen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Metabolism - Mortality - Pathologyen_US
dc.subject.meshNasopharynx - Metabolismen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTrans-Activatorsen_US
dc.subject.meshBeta Cateninen_US
dc.titleDownregulation and abnormal expression of e-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasisen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.emailCheung, ALM:lmcheung@hkucc.hku.hken_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.identifier.authorityCheung, ALM=rp00332en_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10208469-
dc.identifier.scopuseid_2-s2.0-0032940579en_US
dc.identifier.hkuros40259-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032940579&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue4en_US
dc.identifier.spage458en_US
dc.identifier.epage466en_US
dc.identifier.isiWOS:000079619300016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZheng, Z=36792437600en_US
dc.identifier.scopusauthoridPan, J=7404098399en_US
dc.identifier.scopusauthoridChu, B=20833601600en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridCheung, ALM=7401806497en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US

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