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Article: Downregulation and abnormal expression of e-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis
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TitleDownregulation and abnormal expression of e-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis
 
AuthorsZheng, Z
Pan, J
Chu, B
Wong, YC
Cheung, ALM
Tsao, SW1
 
Issue Date1999
 
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
 
CitationHuman Pathology, 1999, v. 30 n. 4, p. 458-466 [How to Cite?]
 
AbstractNasopharyngeal carcinoma (NPC) is predominantly of the undifferentiated histological subtype. Histological differentiation is of limited prognostic significance in NPC. Recent studies have suggested that downregulation of the cadherin-catenin cell adhesion complex may play a crucial role in the initial stage of cancer invasion and metastasis and is associated with poor prognosis in human cancers. Expression of E-cadherin has not been reported previously in NPC, and its prognostic value in NPC is unknown. The purpose of this study was to examine the expression pattern of E-cadherin and its associated partner, β-catenin, in NPC and their possible applications as prognostic markers to predict the clinical outcome of NPC. Expression of the E-cadherin and β-catenin was examined by immunohistochemical methods in 74 cases of primary NPC and 17 of their corresponding lymph node metastases. Normal nasopharyngeal epithelium showed strong and homogeneous immunocytochemical staining of E-cadherin and β-catenin at the cell membranes and intercellular junctions. In contrast, primary NPC showed variable and heterogeneous staining patterns of E-cadherin and β-catenin. Loss of membranous E-cadherin expression was significantly associated with advanced stages of diseases (P < .001). Eighty percent to ninety percent of NPC in stages IV and V (Ho's staging), respectively, showed a reduced (<35%) membranous staining of E- cadherin compared with normal nasopharyngeal epithelium. Expression of β- catenin also was downregulated in advanced NPC. Ninety percent to one hundred percent of NPC in stages IV and V (Ho's staging) expressed a reduction (<35%) of immunocytochemical staining of β-catenin. The expression pattern of β- catenin staining was strongly associated with the expression of E-cadherin (P < .001). Unlike E-cadherin, nuclear staining of β-catenin expression was observed in some of the primary NPC and lymph node metastasis. Reduced expression of E-cadherin and β-catenin expression was associated with a shorter survival of NPC patients (P < .001). In advanced NPC patients (stages IV and V), a significant difference in survival was observed in tumors with higher or lower levels of E-cadherin expression (P = .0224, log-rank test). These observations suggests that expression of E-cadherin and β-catenin may have prognostic values in NPC patients.
 
ISSN0046-8177
2013 Impact Factor: 2.806
2013 SCImago Journal Rankings: 1.483
 
ISI Accession Number IDWOS:000079619300016
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZheng, Z
 
dc.contributor.authorPan, J
 
dc.contributor.authorChu, B
 
dc.contributor.authorWong, YC
 
dc.contributor.authorCheung, ALM
 
dc.contributor.authorTsao, SW
 
dc.date.accessioned2012-06-26T05:55:29Z
 
dc.date.available2012-06-26T05:55:29Z
 
dc.date.issued1999
 
dc.description.abstractNasopharyngeal carcinoma (NPC) is predominantly of the undifferentiated histological subtype. Histological differentiation is of limited prognostic significance in NPC. Recent studies have suggested that downregulation of the cadherin-catenin cell adhesion complex may play a crucial role in the initial stage of cancer invasion and metastasis and is associated with poor prognosis in human cancers. Expression of E-cadherin has not been reported previously in NPC, and its prognostic value in NPC is unknown. The purpose of this study was to examine the expression pattern of E-cadherin and its associated partner, β-catenin, in NPC and their possible applications as prognostic markers to predict the clinical outcome of NPC. Expression of the E-cadherin and β-catenin was examined by immunohistochemical methods in 74 cases of primary NPC and 17 of their corresponding lymph node metastases. Normal nasopharyngeal epithelium showed strong and homogeneous immunocytochemical staining of E-cadherin and β-catenin at the cell membranes and intercellular junctions. In contrast, primary NPC showed variable and heterogeneous staining patterns of E-cadherin and β-catenin. Loss of membranous E-cadherin expression was significantly associated with advanced stages of diseases (P < .001). Eighty percent to ninety percent of NPC in stages IV and V (Ho's staging), respectively, showed a reduced (<35%) membranous staining of E- cadherin compared with normal nasopharyngeal epithelium. Expression of β- catenin also was downregulated in advanced NPC. Ninety percent to one hundred percent of NPC in stages IV and V (Ho's staging) expressed a reduction (<35%) of immunocytochemical staining of β-catenin. The expression pattern of β- catenin staining was strongly associated with the expression of E-cadherin (P < .001). Unlike E-cadherin, nuclear staining of β-catenin expression was observed in some of the primary NPC and lymph node metastasis. Reduced expression of E-cadherin and β-catenin expression was associated with a shorter survival of NPC patients (P < .001). In advanced NPC patients (stages IV and V), a significant difference in survival was observed in tumors with higher or lower levels of E-cadherin expression (P = .0224, log-rank test). These observations suggests that expression of E-cadherin and β-catenin may have prognostic values in NPC patients.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationHuman Pathology, 1999, v. 30 n. 4, p. 458-466 [How to Cite?]
 
dc.identifier.epage466
 
dc.identifier.hkuros40259
 
dc.identifier.isiWOS:000079619300016
 
dc.identifier.issn0046-8177
2013 Impact Factor: 2.806
2013 SCImago Journal Rankings: 1.483
 
dc.identifier.issue4
 
dc.identifier.pmid10208469
 
dc.identifier.scopuseid_2-s2.0-0032940579
 
dc.identifier.spage458
 
dc.identifier.urihttp://hdl.handle.net/10722/149578
 
dc.identifier.volume30
 
dc.languageeng
 
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
 
dc.publisher.placeUnited States
 
dc.relation.ispartofHuman Pathology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshCadherins - Biosynthesis
 
dc.subject.meshCarcinoma - Metabolism - Mortality - Pathology
 
dc.subject.meshCytoskeletal Proteins - Biosynthesis
 
dc.subject.meshDown-Regulation
 
dc.subject.meshHumans
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshLymph Nodes - Metabolism
 
dc.subject.meshLymphatic Metastasis
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNasopharyngeal Neoplasms - Metabolism - Mortality - Pathology
 
dc.subject.meshNasopharynx - Metabolism
 
dc.subject.meshNeoplasm Staging
 
dc.subject.meshSurvival Rate
 
dc.subject.meshTrans-Activators
 
dc.subject.meshBeta Catenin
 
dc.titleDownregulation and abnormal expression of e-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong