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Article: Time course of NOS expression and neuronal death in Clarke's nucleus following traumatic injury in adult rat spinal cord

TitleTime course of NOS expression and neuronal death in Clarke's nucleus following traumatic injury in adult rat spinal cord
Authors
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1998, v. 241 n. 2-3, p. 155-158 How to Cite?
AbstractThe objective of this study was to investigate the influence of the length of the remaining axons on neuronal survival following axonal injury in the adult rat spinal cord. The relationship between the expression of nitric oxide synthase (NOS) and neuronal death was also studied. The time course of NOS expression and neuronal loss was observed in Clarke's nucleus at segment L1 following hemisection of the cord at either segment C3, T1, or T11. NOS- positive neurons were first observed 3 days after injury, rising significantly after 5 days, and reaching a maximum by 10-20 days post- injury. During the same period the number of neurons surviving in the nucleus decreased. The decrease began at 3 days, rapidly decreased after 5 days, and reached a minimum by 40 days post-Injury. Among the three lesioned groups, the highest percentage of NOS expression and neuronal loss was observed in the group with lesions at T11, while the lowest percentage was in the group with lesions at C3. Although the time course of neuronal loss varied following lesion at different spinal levels, in all cases the majority of neurons in Clarke's nucleus had degenerated by 40 days after axotomy.
Persistent Identifierhttp://hdl.handle.net/10722/149575
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYick, LWen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorWong, SYen_US
dc.date.accessioned2012-06-26T05:55:28Z-
dc.date.available2012-06-26T05:55:28Z-
dc.date.issued1998en_US
dc.identifier.citationNeuroscience Letters, 1998, v. 241 n. 2-3, p. 155-158en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/149575-
dc.description.abstractThe objective of this study was to investigate the influence of the length of the remaining axons on neuronal survival following axonal injury in the adult rat spinal cord. The relationship between the expression of nitric oxide synthase (NOS) and neuronal death was also studied. The time course of NOS expression and neuronal loss was observed in Clarke's nucleus at segment L1 following hemisection of the cord at either segment C3, T1, or T11. NOS- positive neurons were first observed 3 days after injury, rising significantly after 5 days, and reaching a maximum by 10-20 days post- injury. During the same period the number of neurons surviving in the nucleus decreased. The decrease began at 3 days, rapidly decreased after 5 days, and reached a minimum by 40 days post-Injury. Among the three lesioned groups, the highest percentage of NOS expression and neuronal loss was observed in the group with lesions at T11, while the lowest percentage was in the group with lesions at C3. Although the time course of neuronal loss varied following lesion at different spinal levels, in all cases the majority of neurons in Clarke's nucleus had degenerated by 40 days after axotomy.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxotomyen_US
dc.subject.meshCell Death - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshNeck - Innervationen_US
dc.subject.meshNeurons - Metabolism - Pathologyen_US
dc.subject.meshNitric Oxide Synthase - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord - Metabolism - Pathologyen_US
dc.subject.meshSpinal Cord Injuries - Metabolism - Pathologyen_US
dc.subject.meshThorax - Innervationen_US
dc.subject.meshTime Factorsen_US
dc.titleTime course of NOS expression and neuronal death in Clarke's nucleus following traumatic injury in adult rat spinal corden_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9507944-
dc.identifier.scopuseid_2-s2.0-0032579383en_US
dc.identifier.hkuros36709-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032579383&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume241en_US
dc.identifier.issue2-3en_US
dc.identifier.spage155en_US
dc.identifier.epage158en_US
dc.identifier.isiWOS:000072064500022-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridYick, LW=6603414804en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridWong, SY=7404590163en_US

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