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Article: Sex hormone-induced prostatic carcinogenesis in the noble rat: The role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate cancer

TitleSex hormone-induced prostatic carcinogenesis in the noble rat: The role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate cancer
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34304
Citation
Prostate, 1998, v. 35 n. 3, p. 165-177 How to Cite?
AbstractBACKGROUND. Despite extensive effort, the mechanisms of prostate carcinogenesis are still unknown. We report on a modified method which enabled us to induce a high incidence of prostate carcinogenesis in the Noble rat and examined the role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) and their receptors during sex hormone-induced prostate carcinogenesis. METHODS. Noble rats were implanted subcutaneously with a combination of testosterone and estradiol capsules for up to 12 months. Animals were sacrificed starting at 2 months after implantation, and the prostate gland was removed for histopathological and immunohistochemical studies. RESULTS. The results showed that hyperplasia/dysplasia was detected as early as 2 months after treatment, while carcinoma in situ was induced in 4 months and adenocarcinoma in 7 months. Our data suggest that IGF-1, produced by stromal cells in hyperplasia, exerted its effects, through a paracrine mode, on epithelial cells which were IGF-1 receptor (IGF-1R)positive. The production of IGF-1 appeared to switch to epithelial cells in adenocarcinoma, through which it regulated tumor cell growth via autocrine mode by binding to IGF-1R of carcinoma cells. On the other hand, VEGF was overexpressed in hyperplastic/dysplastic and carcinoma cells, while VEGF-R was detected in endothelial cells. The results suggest that overexpression of VEGF in deranged epithelia and arterial muscle cells may exert its influence on stromal angiogenesis and abnormal growth of prostate gland. CONCLUSIONS. A modified Noble rat model with a high incidence of prostate carcinogenesis has been developed. Using this model, we have further established that IGF-1 and VEGF may be the critical regulators in mediating epithelial-stromal interactions in sex hormone-induced prostate carcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/149574
ISSN
2015 Impact Factor: 3.778
2015 SCImago Journal Rankings: 1.477
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, YZen_US
dc.contributor.authorWong, YCen_US
dc.date.accessioned2012-06-26T05:55:27Z-
dc.date.available2012-06-26T05:55:27Z-
dc.date.issued1998en_US
dc.identifier.citationProstate, 1998, v. 35 n. 3, p. 165-177en_US
dc.identifier.issn0270-4137en_US
dc.identifier.urihttp://hdl.handle.net/10722/149574-
dc.description.abstractBACKGROUND. Despite extensive effort, the mechanisms of prostate carcinogenesis are still unknown. We report on a modified method which enabled us to induce a high incidence of prostate carcinogenesis in the Noble rat and examined the role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) and their receptors during sex hormone-induced prostate carcinogenesis. METHODS. Noble rats were implanted subcutaneously with a combination of testosterone and estradiol capsules for up to 12 months. Animals were sacrificed starting at 2 months after implantation, and the prostate gland was removed for histopathological and immunohistochemical studies. RESULTS. The results showed that hyperplasia/dysplasia was detected as early as 2 months after treatment, while carcinoma in situ was induced in 4 months and adenocarcinoma in 7 months. Our data suggest that IGF-1, produced by stromal cells in hyperplasia, exerted its effects, through a paracrine mode, on epithelial cells which were IGF-1 receptor (IGF-1R)positive. The production of IGF-1 appeared to switch to epithelial cells in adenocarcinoma, through which it regulated tumor cell growth via autocrine mode by binding to IGF-1R of carcinoma cells. On the other hand, VEGF was overexpressed in hyperplastic/dysplastic and carcinoma cells, while VEGF-R was detected in endothelial cells. The results suggest that overexpression of VEGF in deranged epithelia and arterial muscle cells may exert its influence on stromal angiogenesis and abnormal growth of prostate gland. CONCLUSIONS. A modified Noble rat model with a high incidence of prostate carcinogenesis has been developed. Using this model, we have further established that IGF-1 and VEGF may be the critical regulators in mediating epithelial-stromal interactions in sex hormone-induced prostate carcinogenesis.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34304en_US
dc.relation.ispartofProstateen_US
dc.subject.meshAdenocarcinoma - Etiology - Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinoma In Situ - Etiology - Pathologyen_US
dc.subject.meshCell Transformation, Neoplasticen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEndothelial Growth Factors - Biosynthesis - Physiologyen_US
dc.subject.meshEpithelial Cells - Metabolismen_US
dc.subject.meshEstradiol - Administration & Dosage - Pharmacologyen_US
dc.subject.meshGene Expression - Physiologyen_US
dc.subject.meshInsulin-Like Growth Factor I - Biosynthesis - Physiologyen_US
dc.subject.meshLymphokines - Biosynthesis - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshProstatic Hyperplasia - Etiology - Pathologyen_US
dc.subject.meshProstatic Neoplasms - Etiology - Pathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptor, Igf Type 1 - Physiologyen_US
dc.subject.meshStromal Cells - Metabolismen_US
dc.subject.meshTestosterone - Administration & Dosage - Pharmacologyen_US
dc.subject.meshVascular Endothelial Growth Factor Aen_US
dc.subject.meshVascular Endothelial Growth Factorsen_US
dc.titleSex hormone-induced prostatic carcinogenesis in the noble rat: The role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate canceren_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0045(19980515)35:3<165::AID-PROS2>3.0.CO;2-Gen_US
dc.identifier.pmid9582085-
dc.identifier.scopuseid_2-s2.0-0032525021en_US
dc.identifier.hkuros31287-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032525021&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume35en_US
dc.identifier.issue3en_US
dc.identifier.spage165en_US
dc.identifier.epage177en_US
dc.identifier.isiWOS:000073474300002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, YZ=8581934500en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US

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