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Article: The prostate gland and prostate carcinogenesis.

TitleThe prostate gland and prostate carcinogenesis.
Authors
Issue Date1998
Citation
Italian Journal Of Anatomy And Embryology = Archivio Italiano Di Anatomia Ed Embriologia, 1998, v. 103 n. 4 Suppl 1, p. 237-252 How to Cite?
AbstractDespite extensive research, the mechanisms of prostate carcinogenesis are not well understood. The slow progress in this area is due, at least in part, to lack of a suitable animal model for prostate carcinogenesis. We have developed an animal model, based on the existing sex hormone-induced prostate carcinogenesis in the Noble rat, by substantially increasing the dosage of testosterone while keeping the level of estrogen unchanged. Using the modified method of combination of testosterone and estradiol-17beta (T+E2), it has been shown in Noble rats that prostate carcinogenesis followed a multi-step process involving hyperplasia, dysplasia, and carcinoma. We have demonstrated the importance of TGF-alpha, TGF-beta1 and bFGF in the development of prostate carcinogenesis. This study also established the roles of VEGF and IGF-1, initially as paracrine factors in epithelial-stromal interactions during the process of carcinogenesis and subsequently switching over to an autocrine mode during the establishment of carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/149572
ISSN
2015 SCImago Journal Rankings: 0.316

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_US
dc.contributor.authorWang, YZen_US
dc.contributor.authorTam, NNen_US
dc.date.accessioned2012-06-26T05:55:25Z-
dc.date.available2012-06-26T05:55:25Z-
dc.date.issued1998en_US
dc.identifier.citationItalian Journal Of Anatomy And Embryology = Archivio Italiano Di Anatomia Ed Embriologia, 1998, v. 103 n. 4 Suppl 1, p. 237-252en_US
dc.identifier.issn1122-6714en_US
dc.identifier.urihttp://hdl.handle.net/10722/149572-
dc.description.abstractDespite extensive research, the mechanisms of prostate carcinogenesis are not well understood. The slow progress in this area is due, at least in part, to lack of a suitable animal model for prostate carcinogenesis. We have developed an animal model, based on the existing sex hormone-induced prostate carcinogenesis in the Noble rat, by substantially increasing the dosage of testosterone while keeping the level of estrogen unchanged. Using the modified method of combination of testosterone and estradiol-17beta (T+E2), it has been shown in Noble rats that prostate carcinogenesis followed a multi-step process involving hyperplasia, dysplasia, and carcinoma. We have demonstrated the importance of TGF-alpha, TGF-beta1 and bFGF in the development of prostate carcinogenesis. This study also established the roles of VEGF and IGF-1, initially as paracrine factors in epithelial-stromal interactions during the process of carcinogenesis and subsequently switching over to an autocrine mode during the establishment of carcinoma.en_US
dc.languageengen_US
dc.relation.ispartofItalian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologiaen_US
dc.subject.meshAdenocarcinoma - Chemically Induced - Chemistry - Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshEndothelial Growth Factors - Analysisen_US
dc.subject.meshEstradiol - Toxicityen_US
dc.subject.meshFibroblast Growth Factor 2 - Analysisen_US
dc.subject.meshHyperplasia - Chemically Induced - Pathologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymphokines - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshPrecancerous Conditions - Chemically Induced - Pathologyen_US
dc.subject.meshProstate - Anatomy & Histology - Drug Effects - Pathologyen_US
dc.subject.meshProstatic Neoplasms - Chemically Induced - Chemistry - Pathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReceptor Protein-Tyrosine Kinases - Analysisen_US
dc.subject.meshReceptors, Growth Factor - Analysisen_US
dc.subject.meshReceptors, Vascular Endothelial Growth Factoren_US
dc.subject.meshTestosterone - Administration & Dosage - Toxicityen_US
dc.subject.meshTransforming Growth Factor Alpha - Analysisen_US
dc.subject.meshTransforming Growth Factor Beta - Analysisen_US
dc.subject.meshTransforming Growth Factor Beta1en_US
dc.subject.meshVascular Endothelial Growth Factor Aen_US
dc.subject.meshVascular Endothelial Growth Factorsen_US
dc.titleThe prostate gland and prostate carcinogenesis.en_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11315954-
dc.identifier.scopuseid_2-s2.0-0032229096en_US
dc.identifier.hkuros46875-
dc.identifier.volume103en_US
dc.identifier.issue4 Suppl 1en_US
dc.identifier.spage237en_US
dc.identifier.epage252en_US
dc.publisher.placeItalyen_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridWang, YZ=8581934500en_US
dc.identifier.scopusauthoridTam, NN=7101712624en_US

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