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Article: Human papillomavirus infection and esophageal squamous cell carcinoma

TitleHuman papillomavirus infection and esophageal squamous cell carcinoma
Authors
Issue Date1996
Citation
Zhonghua Bing Li Xue Za Zhi Chinese Journal Of Pathology, 1996, v. 25 n. 6, p. 351-354 How to Cite?
AbstractHuman papillomavirus (HPV) infection, especially high risk types HPV 16 and 18, have been studied widely in cervical cancer. However, HPV infection in esophageal cancer has not been well defined. In the present study, immunohistochemistry, PCR and Southern blot hybridization methods were used to detect HPV infection in 127 cases of esophageal squamous cell carcinoma. Immunohistochemistry results indicated that the virus was detected frequently in well differentiated carcinoma. The positive rates for BPV and HPV E6 protein were 60.6% (77/127) and 43% (54/127) respectively. Meanwhile, PCR and Southern hybridization showed that 35.9% (37/103) of esophageal squamous cell carcinomas have HPV DNA, which included 20.4% (21/103) HPV 16 and 7.8% (8/103) HPV 18. Of the 103 cases, only 1 had both HPV 16 and HPV 18 DNA. Our results suggest that HPV infection is present in esophageal squamous cell carcinoma and may play a role in its pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/149558
ISSN
2015 SCImago Journal Rankings: 0.136

 

DC FieldValueLanguage
dc.contributor.authorHe, Den_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorBu, Hen_US
dc.date.accessioned2012-06-26T05:55:16Z-
dc.date.available2012-06-26T05:55:16Z-
dc.date.issued1996en_US
dc.identifier.citationZhonghua Bing Li Xue Za Zhi Chinese Journal Of Pathology, 1996, v. 25 n. 6, p. 351-354en_US
dc.identifier.issn0529-5807en_US
dc.identifier.urihttp://hdl.handle.net/10722/149558-
dc.description.abstractHuman papillomavirus (HPV) infection, especially high risk types HPV 16 and 18, have been studied widely in cervical cancer. However, HPV infection in esophageal cancer has not been well defined. In the present study, immunohistochemistry, PCR and Southern blot hybridization methods were used to detect HPV infection in 127 cases of esophageal squamous cell carcinoma. Immunohistochemistry results indicated that the virus was detected frequently in well differentiated carcinoma. The positive rates for BPV and HPV E6 protein were 60.6% (77/127) and 43% (54/127) respectively. Meanwhile, PCR and Southern hybridization showed that 35.9% (37/103) of esophageal squamous cell carcinomas have HPV DNA, which included 20.4% (21/103) HPV 16 and 7.8% (8/103) HPV 18. Of the 103 cases, only 1 had both HPV 16 and HPV 18 DNA. Our results suggest that HPV infection is present in esophageal squamous cell carcinoma and may play a role in its pathogenesis.en_US
dc.languageengen_US
dc.relation.ispartofZhonghua bing li xue za zhi Chinese journal of pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntibodies, Viral - Analysisen_US
dc.subject.meshCarcinoma, Squamous Cell - Virologyen_US
dc.subject.meshDna, Viral - Analysisen_US
dc.subject.meshEsophageal Neoplasms - Virologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOncogene Proteins, Viral - Biosynthesisen_US
dc.subject.meshPapillomaviridae - Isolation & Purificationen_US
dc.subject.meshPapillomavirus Infectionsen_US
dc.subject.meshRepressor Proteinsen_US
dc.subject.meshTumor Virus Infectionsen_US
dc.titleHuman papillomavirus infection and esophageal squamous cell carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9388862-
dc.identifier.scopuseid_2-s2.0-0030309892en_US
dc.identifier.volume25en_US
dc.identifier.issue6en_US
dc.identifier.spage351en_US
dc.identifier.epage354en_US
dc.identifier.scopusauthoridHe, D=7403048937en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridBu, H=36846027800en_US

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