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Article: Comparison of [ 125I]iodomelatonin binding sites in infant cerebellum of sudden infant death syndrome and non-sudden infant death syndrome

TitleComparison of [ 125I]iodomelatonin binding sites in infant cerebellum of sudden infant death syndrome and non-sudden infant death syndrome
Authors
KeywordsCerebellum
Guanine Nucleotide Binding Protein
Melatonin Receptors
Sudden Infant Death Syndrome
Issue Date1995
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1995, v. 197 n. 2, p. 154-158 How to Cite?
Abstract[ 125I]Iodomelatonin binding sites in human infant cerebellum were studied by radioligand receptor binding assay and in vitro quantitative autoradiography. The binding sites characterized in membrane preparations revealed saturable, reversible and highly specific binding sites with a K(d) value of 21.2 ± 8.33 pM and a B(max) value of 2.02 ± 0.52 fmol/mg protein. 10 μM of CGPγS significantly reduced the binding capacity, suggesting the possible G-protein coupling of the binding sites. Autoradiographic study showed that the labelling was mainly located in the cerebellar cortex. On comparison of the binding parameters from cerebellum of sudden infant death syndrome (SIDS) and non-SIDS infants, no significant change in binding capacity and binding affinity was detected. These findings suggest that the binding sites in cerebellum may not be related to the etiology of SIDS.
Persistent Identifierhttp://hdl.handle.net/10722/149552
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuan, Hen_US
dc.contributor.authorChan, CWYen_US
dc.contributor.authorSturner, WQen_US
dc.contributor.authorPang, SFen_US
dc.contributor.authorBrown, GMen_US
dc.date.accessioned2012-06-26T05:55:13Z-
dc.date.available2012-06-26T05:55:13Z-
dc.date.issued1995en_US
dc.identifier.citationNeuroscience Letters, 1995, v. 197 n. 2, p. 154-158en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/149552-
dc.description.abstract[ 125I]Iodomelatonin binding sites in human infant cerebellum were studied by radioligand receptor binding assay and in vitro quantitative autoradiography. The binding sites characterized in membrane preparations revealed saturable, reversible and highly specific binding sites with a K(d) value of 21.2 ± 8.33 pM and a B(max) value of 2.02 ± 0.52 fmol/mg protein. 10 μM of CGPγS significantly reduced the binding capacity, suggesting the possible G-protein coupling of the binding sites. Autoradiographic study showed that the labelling was mainly located in the cerebellar cortex. On comparison of the binding parameters from cerebellum of sudden infant death syndrome (SIDS) and non-SIDS infants, no significant change in binding capacity and binding affinity was detected. These findings suggest that the binding sites in cerebellum may not be related to the etiology of SIDS.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subjectCerebellumen_US
dc.subjectGuanine Nucleotide Binding Proteinen_US
dc.subjectMelatonin Receptorsen_US
dc.subjectSudden Infant Death Syndromeen_US
dc.titleComparison of [ 125I]iodomelatonin binding sites in infant cerebellum of sudden infant death syndrome and non-sudden infant death syndromeen_US
dc.typeArticleen_US
dc.identifier.emailChan, CWY:camchan@hku.hken_US
dc.identifier.authorityChan, CWY=rp01311en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0304-3940(95)11904-Ben_US
dc.identifier.pmid8552283-
dc.identifier.scopuseid_2-s2.0-0028981876en_US
dc.identifier.volume197en_US
dc.identifier.issue2en_US
dc.identifier.spage154en_US
dc.identifier.epage158en_US
dc.identifier.isiWOS:A1995RW40600018-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridYuan, H=7402446929en_US
dc.identifier.scopusauthoridChan, CWY=12240386600en_US
dc.identifier.scopusauthoridSturner, WQ=7005358417en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US
dc.identifier.scopusauthoridBrown, GM=35493704500en_US

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