File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor

TitleRescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor
Authors
Issue Date1995
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 1995, v. 92 n. 21, p. 9771-9775 How to Cite?
AbstractGlial cell line-derived neurotrophic factor (GDNF) has been shown to rescue developing motoneurons in vivo and in vitro from both naturally occurring and axotomy-induced cell death. To test whether GDNF has trophic effects on adult motoneurons, we used a mouse model of injury-induced adult motoneuron degeneration. Injuring adult motoneuron axons at the exit point of the nerve from the spinal cord (avulsion) resulted in a 70% loss of motoneurons by 3 weeks following surgery and a complete loss by 6 weeks. Half of the loss was prevented by GDNF treatment. GDNF also induced an increase (hypertrophy) in the size of surviving motoneurons. These data provide strong evidence that the survival of injured adult mammalian motoneurons can be promoted by a known neurotrophic factor, suggesting the potential use of GDNF in therapeutic approaches to adult-onset motoneuron diseases such as amyotrophic lateral sclerosis.
Persistent Identifierhttp://hdl.handle.net/10722/149550
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Len_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorLin, LFHen_US
dc.contributor.authorLei, Men_US
dc.contributor.authorOppenheim, RWen_US
dc.contributor.authorHouenou, LJen_US
dc.date.accessioned2012-06-26T05:55:11Z-
dc.date.available2012-06-26T05:55:11Z-
dc.date.issued1995en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 1995, v. 92 n. 21, p. 9771-9775en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/149550-
dc.description.abstractGlial cell line-derived neurotrophic factor (GDNF) has been shown to rescue developing motoneurons in vivo and in vitro from both naturally occurring and axotomy-induced cell death. To test whether GDNF has trophic effects on adult motoneurons, we used a mouse model of injury-induced adult motoneuron degeneration. Injuring adult motoneuron axons at the exit point of the nerve from the spinal cord (avulsion) resulted in a 70% loss of motoneurons by 3 weeks following surgery and a complete loss by 6 weeks. Half of the loss was prevented by GDNF treatment. GDNF also induced an increase (hypertrophy) in the size of surviving motoneurons. These data provide strong evidence that the survival of injured adult mammalian motoneurons can be promoted by a known neurotrophic factor, suggesting the potential use of GDNF in therapeutic approaches to adult-onset motoneuron diseases such as amyotrophic lateral sclerosis.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain-Derived Neurotrophic Factoren_US
dc.subject.meshCell Counten_US
dc.subject.meshCell Lineen_US
dc.subject.meshGlial Cell Line-Derived Neurotrophic Factoren_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshInsulin-Like Growth Factor I - Pharmacologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMotor Neurons - Cytology - Drug Effects - Physiologyen_US
dc.subject.meshNadph Dehydrogenase - Isolation & Purificationen_US
dc.subject.meshNerve Degeneration - Drug Effectsen_US
dc.subject.meshNerve Growth Factors - Pharmacologyen_US
dc.subject.meshNerve Tissue Proteins - Pharmacologyen_US
dc.subject.meshNitric Oxide Synthase - Isolation & Purificationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Nerve Roots - Cytology - Drug Effects - Physiology - Surgeryen_US
dc.titleRescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factoren_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.92.21.9771en_US
dc.identifier.pmid7568215-
dc.identifier.scopuseid_2-s2.0-0028822549en_US
dc.identifier.volume92en_US
dc.identifier.issue21en_US
dc.identifier.spage9771en_US
dc.identifier.epage9775en_US
dc.identifier.isiWOS:A1995RZ07200070-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, L=9038682000en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridLin, LFH=24923153600en_US
dc.identifier.scopusauthoridLei, M=54887929900en_US
dc.identifier.scopusauthoridOppenheim, RW=7102628195en_US
dc.identifier.scopusauthoridHouenou, LJ=7003871997en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats