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Article: Effect of trichosanthin and momorcharins on isolated rat hepatocytes

TitleEffect of trichosanthin and momorcharins on isolated rat hepatocytes
Authors
Ng, TBLiub, WKTsao, SWYeun, HW
KeywordsEnzyme activities
Hepatocyte culture
Morphology
Plant proteins
Issue Date1994
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal Of Ethnopharmacology, 1994, v. 43 n. 2, p. 81-87 How to Cite?
DOI: http://dx.doi.org/10.1016/0378-8741(94)90007-8
Abstractα-Momorcharin, β-momorcharin and trichosanthin increased the secretion of glutamate-pyruvate transaminase, lactate dehydrogenase and isocitrate dehydrogenase by isolated rat hepatocytes into the culture medium. This hepatotoxic effect of the proteins appeared to be concentration-dependent. The plant proteins induced morphological changes in hepatocytes including increased formation of cytoplasmic blebs and a reduction of microvilli on plasma membrane.
Persistent Identifierhttp://hdl.handle.net/10722/149546
ISSN
0378-8741
2023 Impact Factor: 4.8
2023 SCImago Journal Rankings: 0.936
ISI Accession Number ID
WOS:A1994NW74600003

 

DC FieldValueLanguage
dc.contributor.authorNg, TBen_US
dc.contributor.authorLiub, WKen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorYeun, HWen_US
dc.date.accessioned2012-06-26T05:55:09Z-
dc.date.available2012-06-26T05:55:09Z-
dc.date.issued1994en_US
dc.identifier.citationJournal Of Ethnopharmacology, 1994, v. 43 n. 2, p. 81-87en_US
dc.identifier.issn0378-8741en_US
dc.identifier.urihttp://hdl.handle.net/10722/149546-
dc.description.abstractα-Momorcharin, β-momorcharin and trichosanthin increased the secretion of glutamate-pyruvate transaminase, lactate dehydrogenase and isocitrate dehydrogenase by isolated rat hepatocytes into the culture medium. This hepatotoxic effect of the proteins appeared to be concentration-dependent. The plant proteins induced morphological changes in hepatocytes including increased formation of cytoplasmic blebs and a reduction of microvilli on plasma membrane.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_US
dc.relation.ispartofJournal of Ethnopharmacologyen_US
dc.subjectEnzyme activities-
dc.subjectHepatocyte culture-
dc.subjectMorphology-
dc.subjectPlant proteins-
dc.subject.meshAlanine Transaminase - Secretionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshGalactosamine - Pharmacologyen_US
dc.subject.meshIsocitrate Dehydrogenase - Secretionen_US
dc.subject.meshL-Lactate Dehydrogenase - Secretionen_US
dc.subject.meshLiver - Drug Effects - Enzymology - Ultrastructureen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrovilli - Drug Effectsen_US
dc.subject.meshPlant Proteins - Isolation & Purification - Pharmacologyen_US
dc.subject.meshPlants, Medicinal - Chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRibosomal Proteinsen_US
dc.subject.meshRibosome Inactivating Proteinsen_US
dc.subject.meshTrichosanthin - Isolation & Purification - Pharmacologyen_US
dc.titleEffect of trichosanthin and momorcharins on isolated rat hepatocytesen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0378-8741(94)90007-8en_US
dc.identifier.pmid7967659-
dc.identifier.scopuseid_2-s2.0-0028285748en_US
dc.identifier.hkuros4712-
dc.identifier.volume43en_US
dc.identifier.issue2en_US
dc.identifier.spage81en_US
dc.identifier.epage87en_US
dc.identifier.isiWOS:A1994NW74600003-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridNg, TB=24431595400en_US
dc.identifier.scopusauthoridLiub, WK=16157485400en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridYeun, HW=16159487800en_US
dc.identifier.issnl0378-8741-

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