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Article: Implantation of PNS graft inhibits the induction of neuronal nitric oxide synthase and enhances the survival of spinal motoneurons following root avulsion

TitleImplantation of PNS graft inhibits the induction of neuronal nitric oxide synthase and enhances the survival of spinal motoneurons following root avulsion
Authors
Issue Date1994
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 1994, v. 129 n. 2, p. 335-339 How to Cite?
AbstractIn a spinal root injury model, our previous studies have shown that induction of nitric oxide synthase (NOS) appears only in spinal motoneurons of the root-avulsed segment in which significant motoneuron loss occurs but not in those of the distal root-axotomized segment (root axotomy 5-10 mm from the spinal cord) in which most motoneurons survive the injury. One hypothesis for the different response of motoneurons to root avulsion and distal root axotomy is that neurotrophic factors produced by the remaining peripheral nervous system (PNS) component are available for the distally axotomized motoneurons but are not available following avulsion. This hypothesis is tested in the present study by implantation of a PNS graft following the root avulsion. Results of the present study show that implantation of a PNS graft significantly enhances the survival of motoneurons following avulsion. Expression of NOS due to avulsion injury is completely inhibited in all motoneurons that regrow into the PNS graft. These results indicate that induction of NOS in avulsed motoneurons may result from the deprivation of neurotrophic factors produced by the PNS component, and the survival promoting effects of neurotrophic factors may be achieved by modifying certain cellular molecules such as NOS.
Persistent Identifierhttp://hdl.handle.net/10722/149542
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Wen_US
dc.contributor.authorHan, Ken_US
dc.contributor.authorLi, Len_US
dc.contributor.authorSchinco, FPen_US
dc.date.accessioned2012-06-26T05:55:06Z-
dc.date.available2012-06-26T05:55:06Z-
dc.date.issued1994en_US
dc.identifier.citationExperimental Neurology, 1994, v. 129 n. 2, p. 335-339en_US
dc.identifier.issn0014-4886en_US
dc.identifier.urihttp://hdl.handle.net/10722/149542-
dc.description.abstractIn a spinal root injury model, our previous studies have shown that induction of nitric oxide synthase (NOS) appears only in spinal motoneurons of the root-avulsed segment in which significant motoneuron loss occurs but not in those of the distal root-axotomized segment (root axotomy 5-10 mm from the spinal cord) in which most motoneurons survive the injury. One hypothesis for the different response of motoneurons to root avulsion and distal root axotomy is that neurotrophic factors produced by the remaining peripheral nervous system (PNS) component are available for the distally axotomized motoneurons but are not available following avulsion. This hypothesis is tested in the present study by implantation of a PNS graft following the root avulsion. Results of the present study show that implantation of a PNS graft significantly enhances the survival of motoneurons following avulsion. Expression of NOS due to avulsion injury is completely inhibited in all motoneurons that regrow into the PNS graft. These results indicate that induction of NOS in avulsed motoneurons may result from the deprivation of neurotrophic factors produced by the PNS component, and the survival promoting effects of neurotrophic factors may be achieved by modifying certain cellular molecules such as NOS.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_US
dc.relation.ispartofExperimental Neurologyen_US
dc.subject.meshAmino Acid Oxidoreductases - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Markers - Analysisen_US
dc.subject.meshCell Survivalen_US
dc.subject.meshEnzyme Inductionen_US
dc.subject.meshFemoral Nerve - Physiology - Transplantationen_US
dc.subject.meshMotor Neurons - Cytology - Enzymology - Pathologyen_US
dc.subject.meshNadph Dehydrogenase - Analysisen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord - Cytology - Enzymologyen_US
dc.subject.meshSpinal Cord Injuries - Enzymology - Physiopathologyen_US
dc.subject.meshSpinal Nerve Roots - Physiologyen_US
dc.titleImplantation of PNS graft inhibits the induction of neuronal nitric oxide synthase and enhances the survival of spinal motoneurons following root avulsionen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/exnr.1994.1176en_US
dc.identifier.pmid7525335-
dc.identifier.scopuseid_2-s2.0-0027987963en_US
dc.identifier.volume129en_US
dc.identifier.issue2en_US
dc.identifier.spage335en_US
dc.identifier.epage339en_US
dc.identifier.isiWOS:A1994PT22600018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridHan, K=7402963531en_US
dc.identifier.scopusauthoridLi, L=9038682000en_US
dc.identifier.scopusauthoridSchinco, FP=6506967600en_US

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