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Article: Molecular genetic evidence of a unifocal origin for human serous ovarian carcinomas

TitleMolecular genetic evidence of a unifocal origin for human serous ovarian carcinomas
Authors
Issue Date1993
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 1993, v. 48 n. 1, p. 5-10 How to Cite?
AbstractThe hypothesis that ovarian cancer is multifocal in origin was examined using molecular genetic techniques. Patterns of allelic deletion on chromosome 17 were studied in 16 informative cases of Stage III serous epithelial ovarian carcinoma. DNA was extracted from specimens collected from the omentum and both ovaries, and the specific alleles and chromosomal loci involved in the deletion were identified and compared. In all cases, the patterns of allelic deletion were identical for the tumors that had been collected from different sites in the same patients. In addition, 4 of the 16 cases were heterozygous for the hypoxanthine phosphoribosyl transferase (HPRT) gene on the X-chromosome and were examined for methylation status. In all 4, the same parental allele of the HPRT gene was methylated in tumor cells collected from both ovarian and omental sites, suggesting that the patterns of inactivation of the X-chromosome are identical. This pattern of allelic deletion and HPRT-gene methylation in tumor samples collected from different sites implies that ovarian carcinomas have a unifocal origin.
Persistent Identifierhttp://hdl.handle.net/10722/149537
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_US
dc.contributor.authorMok, CHen_US
dc.contributor.authorKnapp, RCen_US
dc.contributor.authorOike, Ken_US
dc.contributor.authorMuto, MGen_US
dc.contributor.authorWelch, WRen_US
dc.contributor.authorGoodman, HMen_US
dc.contributor.authorSheets, EEen_US
dc.contributor.authorBerkowitz, RSen_US
dc.contributor.authorLau, CCen_US
dc.date.accessioned2012-06-26T05:54:58Z-
dc.date.available2012-06-26T05:54:58Z-
dc.date.issued1993en_US
dc.identifier.citationGynecologic Oncology, 1993, v. 48 n. 1, p. 5-10en_US
dc.identifier.issn0090-8258en_US
dc.identifier.urihttp://hdl.handle.net/10722/149537-
dc.description.abstractThe hypothesis that ovarian cancer is multifocal in origin was examined using molecular genetic techniques. Patterns of allelic deletion on chromosome 17 were studied in 16 informative cases of Stage III serous epithelial ovarian carcinoma. DNA was extracted from specimens collected from the omentum and both ovaries, and the specific alleles and chromosomal loci involved in the deletion were identified and compared. In all cases, the patterns of allelic deletion were identical for the tumors that had been collected from different sites in the same patients. In addition, 4 of the 16 cases were heterozygous for the hypoxanthine phosphoribosyl transferase (HPRT) gene on the X-chromosome and were examined for methylation status. In all 4, the same parental allele of the HPRT gene was methylated in tumor cells collected from both ovarian and omental sites, suggesting that the patterns of inactivation of the X-chromosome are identical. This pattern of allelic deletion and HPRT-gene methylation in tumor samples collected from different sites implies that ovarian carcinomas have a unifocal origin.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_US
dc.relation.ispartofGynecologic Oncologyen_US
dc.subject.meshAllelesen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChromosomes, Human, Pair 17 - Physiologyen_US
dc.subject.meshCystadenocarcinoma - Genetics - Secondaryen_US
dc.subject.meshDna Probesen_US
dc.subject.meshDosage Compensation, Geneticen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHumansen_US
dc.subject.meshNeoplasms, Multiple Primary - Geneticsen_US
dc.subject.meshOvarian Neoplasms - Genetics - Pathologyen_US
dc.titleMolecular genetic evidence of a unifocal origin for human serous ovarian carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/gyno.1993.1002en_US
dc.identifier.pmid8423021-
dc.identifier.scopuseid_2-s2.0-0027476142en_US
dc.identifier.volume48en_US
dc.identifier.issue1en_US
dc.identifier.spage5en_US
dc.identifier.epage10en_US
dc.identifier.isiWOS:A1993KK69000002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridMok, CH=7102344233en_US
dc.identifier.scopusauthoridKnapp, RC=7201853287en_US
dc.identifier.scopusauthoridOike, K=6602813848en_US
dc.identifier.scopusauthoridMuto, MG=7102795179en_US
dc.identifier.scopusauthoridWelch, WR=35265514400en_US
dc.identifier.scopusauthoridGoodman, HM=55207871500en_US
dc.identifier.scopusauthoridSheets, EE=7003289543en_US
dc.identifier.scopusauthoridBerkowitz, RS=7201352221en_US
dc.identifier.scopusauthoridLau, CC=7401968381en_US

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