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Article: Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy

TitleMutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy
Authors
Issue Date1993
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1993, v. 53 n. 7, p. 1489-1492 How to Cite?
AbstractThe mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras revealed a close association with the histological cell types of the tumor. Mutation of K-ras was detected at a higher frequency in mucinous borderline tumor (identified in 12 of 19 cases) compared to serous borderline tumor (identified in 9 of 25 cases). K-ras mutation was also detected in invasive mucinous and serous ovarian carcinomas, hence supporting the notion that borderline ovarian tumors may represent a pathological continuum between benign and frankly invasive diseases.
Persistent Identifierhttp://hdl.handle.net/10722/149535
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMok, SCHen_US
dc.contributor.authorBell, DAen_US
dc.contributor.authorKnapp, RCen_US
dc.contributor.authorFishbaugh, PMen_US
dc.contributor.authorWelch, WRen_US
dc.contributor.authorMuto, MGen_US
dc.contributor.authorBerkowitz, RSen_US
dc.contributor.authorTsao, SWen_US
dc.date.accessioned2012-06-26T05:54:56Z-
dc.date.available2012-06-26T05:54:56Z-
dc.date.issued1993en_US
dc.identifier.citationCancer Research, 1993, v. 53 n. 7, p. 1489-1492en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/149535-
dc.description.abstractThe mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras revealed a close association with the histological cell types of the tumor. Mutation of K-ras was detected at a higher frequency in mucinous borderline tumor (identified in 12 of 19 cases) compared to serous borderline tumor (identified in 9 of 25 cases). K-ras mutation was also detected in invasive mucinous and serous ovarian carcinomas, hence supporting the notion that borderline ovarian tumors may represent a pathological continuum between benign and frankly invasive diseases.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAdenocarcinoma, Mucinous - Genetics - Pathologyen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCodon - Geneticsen_US
dc.subject.meshCystadenocarcinoma - Genetics - Pathologyen_US
dc.subject.meshDna Mutational Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Ras - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMutation - Geneticsen_US
dc.subject.meshOvarian Neoplasms - Genetics - Pathologyen_US
dc.titleMutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancyen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid8384077-
dc.identifier.scopuseid_2-s2.0-0027413895en_US
dc.identifier.volume53en_US
dc.identifier.issue7en_US
dc.identifier.spage1489en_US
dc.identifier.epage1492en_US
dc.identifier.isiWOS:A1993KV61500004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMok, SCH=7006015487en_US
dc.identifier.scopusauthoridBell, DA=7403648185en_US
dc.identifier.scopusauthoridKnapp, RC=7201853287en_US
dc.identifier.scopusauthoridFishbaugh, PM=6507784159en_US
dc.identifier.scopusauthoridWelch, WR=35265514400en_US
dc.identifier.scopusauthoridMuto, MG=7102795179en_US
dc.identifier.scopusauthoridBerkowitz, RS=7201352221en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US

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