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Article: Effects of the Booroola gene (Fec(B)) on body weight, ovarian development and hormone concentrations during fetal life

TitleEffects of the Booroola gene (Fec(B)) on body weight, ovarian development and hormone concentrations during fetal life
Authors
Issue Date1993
PublisherSociety for Reproduction and Fertility. The Journal's web site is located at http://www.journals-of-reproduction.org.uk
Citation
Journal Of Reproduction And Fertility, 1993, v. 98 n. 1, p. 41-54 How to Cite?
AbstractThe aim of this study was to determine whether the Fec(B) gene influenced some aspects of fetal development in sheep. Carrier (BB/B+) and non-carrier (++) female fetuses were recovered at specific times of gestation, namely, days 40, 55, 75, 90, 95 and 135. The results showed that the Fec(B) gene influenced litter size, body weight and ovarian development during fetal life. The mean litter sizes were larger (P < 0.05) and body weights were lighter (P < 0.05) at most gestational ages in BB/B+ than in ++ fetuses. Morphometric studies of the ovary showed that the development of the BB/B+ ovaries was retarded: the ++ genotype had more oogonia at day 40 (P < 0.01), more germ cells entering meiosis at day 55, more primordial follicles developing at days 75, 90 and 95 (P < 0.05), a greater loss of germ cells by atresia at day 90 (P < 0.01) and more growing follicles (P < 0.01) and more antral follicles (P < 0.05) at day 135. Differences between the BB/B+ and ++ genotypes in the plasma concentrations of immunoreactive (i) inhibin, i-FSH, bioactive (b)-FSH or (i)-LH were not apparent at any age except for i-LH at day 75 (BB/B+ > ++; P < 0.05). Likewise no differences were noted in the contents of ovarian or adrenal oestradiol or i-inhibin except for i-inhibin in the adrenal at day 75 (++ > BB/B+, P < 0.01). No differences between the genotypes were noted in the i-inhibin contents of the mesonephros at day 40. In mid- to late but not early gestation (i.e. days 40 and 55) significant correlations (i.e. P < 0.05) were noted between litter size and body weight at days 75, 90 and 135, and between litter size and ovary weight, ovary volume, adrenal weight and pituitary weight at day 135. To eliminate the effect of litter size, equal numbers of BB/B+ and ++ embryos were transferred to respective recipient ewes, and fetuses were recovered at the equivalent of days 40 and 90 of gestation. The results showed that the genotypic difference in fetal body weight at day 40 (++ > BB, P < 0.001) and in number of oogonia at day 90 (++ > BB/B+, P < 0.05) were independent of litter size. We hypothesize that many of the differences between the Booroola genotypes in ovarian follicular development and pituitary function in neonatal and adult life may be a consequence of differences in the timing or rate of body weight or organ development in fetal life.
Persistent Identifierhttp://hdl.handle.net/10722/149531
ISSN
2002 Impact Factor: 2.865
2003 SCImago Journal Rankings: 0.665
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSmith, Pen_US
dc.contributor.authorO, WSen_US
dc.contributor.authorHudson, NLen_US
dc.contributor.authorShaw, Len_US
dc.contributor.authorHeath, DAen_US
dc.contributor.authorCondell, Len_US
dc.contributor.authorPhillips, DJen_US
dc.contributor.authorMcnatty, KPen_US
dc.date.accessioned2012-06-26T05:54:53Z-
dc.date.available2012-06-26T05:54:53Z-
dc.date.issued1993en_US
dc.identifier.citationJournal Of Reproduction And Fertility, 1993, v. 98 n. 1, p. 41-54en_US
dc.identifier.issn0022-4251en_US
dc.identifier.urihttp://hdl.handle.net/10722/149531-
dc.description.abstractThe aim of this study was to determine whether the Fec(B) gene influenced some aspects of fetal development in sheep. Carrier (BB/B+) and non-carrier (++) female fetuses were recovered at specific times of gestation, namely, days 40, 55, 75, 90, 95 and 135. The results showed that the Fec(B) gene influenced litter size, body weight and ovarian development during fetal life. The mean litter sizes were larger (P < 0.05) and body weights were lighter (P < 0.05) at most gestational ages in BB/B+ than in ++ fetuses. Morphometric studies of the ovary showed that the development of the BB/B+ ovaries was retarded: the ++ genotype had more oogonia at day 40 (P < 0.01), more germ cells entering meiosis at day 55, more primordial follicles developing at days 75, 90 and 95 (P < 0.05), a greater loss of germ cells by atresia at day 90 (P < 0.01) and more growing follicles (P < 0.01) and more antral follicles (P < 0.05) at day 135. Differences between the BB/B+ and ++ genotypes in the plasma concentrations of immunoreactive (i) inhibin, i-FSH, bioactive (b)-FSH or (i)-LH were not apparent at any age except for i-LH at day 75 (BB/B+ > ++; P < 0.05). Likewise no differences were noted in the contents of ovarian or adrenal oestradiol or i-inhibin except for i-inhibin in the adrenal at day 75 (++ > BB/B+, P < 0.01). No differences between the genotypes were noted in the i-inhibin contents of the mesonephros at day 40. In mid- to late but not early gestation (i.e. days 40 and 55) significant correlations (i.e. P < 0.05) were noted between litter size and body weight at days 75, 90 and 135, and between litter size and ovary weight, ovary volume, adrenal weight and pituitary weight at day 135. To eliminate the effect of litter size, equal numbers of BB/B+ and ++ embryos were transferred to respective recipient ewes, and fetuses were recovered at the equivalent of days 40 and 90 of gestation. The results showed that the genotypic difference in fetal body weight at day 40 (++ > BB, P < 0.001) and in number of oogonia at day 90 (++ > BB/B+, P < 0.05) were independent of litter size. We hypothesize that many of the differences between the Booroola genotypes in ovarian follicular development and pituitary function in neonatal and adult life may be a consequence of differences in the timing or rate of body weight or organ development in fetal life.en_US
dc.languageengen_US
dc.publisherSociety for Reproduction and Fertility. The Journal's web site is located at http://www.journals-of-reproduction.org.uken_US
dc.relation.ispartofJournal of Reproduction and Fertilityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEmbryo Transferen_US
dc.subject.meshEmbryonic And Fetal Development - Geneticsen_US
dc.subject.meshEstradiol - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFertility - Geneticsen_US
dc.subject.meshFetal Blood - Chemistryen_US
dc.subject.meshFollicle Stimulating Hormone - Blooden_US
dc.subject.meshGenotypeen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshInhibins - Blooden_US
dc.subject.meshLitter Size - Geneticsen_US
dc.subject.meshLuteinizing Hormone - Blooden_US
dc.subject.meshOvary - Embryologyen_US
dc.subject.meshSheep - Blood - Geneticsen_US
dc.titleEffects of the Booroola gene (Fec(B)) on body weight, ovarian development and hormone concentrations during fetal lifeen_US
dc.typeArticleen_US
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_US
dc.identifier.authorityO, WS=rp00315en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8345478-
dc.identifier.scopuseid_2-s2.0-0027235962en_US
dc.identifier.hkuros7746-
dc.identifier.volume98en_US
dc.identifier.issue1en_US
dc.identifier.spage41en_US
dc.identifier.epage54en_US
dc.identifier.isiWOS:A1993LH23400006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSmith, P=8432710700en_US
dc.identifier.scopusauthoridO, WS=6701729369en_US
dc.identifier.scopusauthoridHudson, NL=7103017859en_US
dc.identifier.scopusauthoridShaw, L=7402573108en_US
dc.identifier.scopusauthoridHeath, DA=7202415195en_US
dc.identifier.scopusauthoridCondell, L=7801513078en_US
dc.identifier.scopusauthoridPhillips, DJ=7404519340en_US
dc.identifier.scopusauthoridMcNatty, KP=7007075253en_US

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