File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Increased expression of nitric oxide synthase in hypothalamic neuronal regeneration

TitleIncreased expression of nitric oxide synthase in hypothalamic neuronal regeneration
Authors
Issue Date1993
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 1993, v. 121 n. 2, p. 279-283 How to Cite?
AbstractThis investigation deals with the histochemical and scanning electron microscopic (SEM) correlates that depict regeneration of the neurohypophyseal system that may be nitric oxide dependent following hypophysectomy in the rodent hypothalamus. NOS histochemistry and correlative SEM were employed to establish the rates of regrowth and appearance of NOS-positive supraoptic (SON) and paraventricular (PVN) neurites and their cell bodies following hypophysectomy. NOS activity increased significantly in SON and PVN neuronal perikarya and regenerating axons by 2 weeks. NOS-positive neurites were observed to regrow into the adjacent median eminence and insinuate into the lumen of the third cerebral ventricle. By 4 weeks posthypophysectomy, NOS staining of SON and PVN neurons and their regrown neurites had returned to normal control levels. Despite this fact, large complexes of apparent magnocellular neurites remained upon the floor of the third cerebral ventricle as observed with SEM. These observations support the hypothesis that NO may play a fundamental role in the process of regeneration, plasticity, and retargeting of SON and PVN axons following injury.
Persistent Identifierhttp://hdl.handle.net/10722/149529
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Wen_US
dc.contributor.authorScott, DEen_US
dc.date.accessioned2012-06-26T05:54:51Z-
dc.date.available2012-06-26T05:54:51Z-
dc.date.issued1993en_US
dc.identifier.citationExperimental Neurology, 1993, v. 121 n. 2, p. 279-283en_US
dc.identifier.issn0014-4886en_US
dc.identifier.urihttp://hdl.handle.net/10722/149529-
dc.description.abstractThis investigation deals with the histochemical and scanning electron microscopic (SEM) correlates that depict regeneration of the neurohypophyseal system that may be nitric oxide dependent following hypophysectomy in the rodent hypothalamus. NOS histochemistry and correlative SEM were employed to establish the rates of regrowth and appearance of NOS-positive supraoptic (SON) and paraventricular (PVN) neurites and their cell bodies following hypophysectomy. NOS activity increased significantly in SON and PVN neuronal perikarya and regenerating axons by 2 weeks. NOS-positive neurites were observed to regrow into the adjacent median eminence and insinuate into the lumen of the third cerebral ventricle. By 4 weeks posthypophysectomy, NOS staining of SON and PVN neurons and their regrown neurites had returned to normal control levels. Despite this fact, large complexes of apparent magnocellular neurites remained upon the floor of the third cerebral ventricle as observed with SEM. These observations support the hypothesis that NO may play a fundamental role in the process of regeneration, plasticity, and retargeting of SON and PVN axons following injury.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_US
dc.relation.ispartofExperimental Neurologyen_US
dc.subject.meshAmino Acid Oxidoreductases - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHypothalamus - Metabolism - Ultrastructureen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshNeurites - Metabolism - Ultrastructureen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleIncreased expression of nitric oxide synthase in hypothalamic neuronal regenerationen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/exnr.1993.1097en_US
dc.identifier.pmid7687963-
dc.identifier.scopuseid_2-s2.0-0027160962en_US
dc.identifier.volume121en_US
dc.identifier.issue2en_US
dc.identifier.spage279en_US
dc.identifier.epage283en_US
dc.identifier.isiWOS:A1993LP25700017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridScott, DE=7404951677en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats