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Article: Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion

TitleInhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion
Authors
Issue Date1993
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1993, v. 153 n. 2, p. 121-124 How to Cite?
AbstractOur previous studies have shown that nitric oxide synthase (NOS) can be induced in motoneurons after spinal root avulsion lesion and the lesion-induced NOS is coincident with the death of the injured neurons. The present study examined whether the death of injured motoneurons can be prevented by inhibition of NOS. Nitroarginine, a specific inhibitor of NOS, was injected into adult rats which underwent spinal root avulsion. At a dose of 50 mg/kg/day, nitroarginine significantly inhibited the activity of lesion-induced NOS and significantly reduced the death of motoneurons due to spinal root avulsion. Results of the present study indicate that NO, produced by lesion-induced NOS, may be involved in and responsible for the neuronal death after traumatic injury.
Persistent Identifierhttp://hdl.handle.net/10722/149528
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Wen_US
dc.contributor.authorLi, Len_US
dc.date.accessioned2012-06-26T05:54:51Z-
dc.date.available2012-06-26T05:54:51Z-
dc.date.issued1993en_US
dc.identifier.citationNeuroscience Letters, 1993, v. 153 n. 2, p. 121-124en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/149528-
dc.description.abstractOur previous studies have shown that nitric oxide synthase (NOS) can be induced in motoneurons after spinal root avulsion lesion and the lesion-induced NOS is coincident with the death of the injured neurons. The present study examined whether the death of injured motoneurons can be prevented by inhibition of NOS. Nitroarginine, a specific inhibitor of NOS, was injected into adult rats which underwent spinal root avulsion. At a dose of 50 mg/kg/day, nitroarginine significantly inhibited the activity of lesion-induced NOS and significantly reduced the death of motoneurons due to spinal root avulsion. Results of the present study indicate that NO, produced by lesion-induced NOS, may be involved in and responsible for the neuronal death after traumatic injury.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAmino Acid Oxidoreductases - Antagonists & Inhibitorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshCell Death - Physiologyen_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshMotor Neurons - Pathologyen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord Injuries - Enzymology - Pathologyen_US
dc.titleInhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsionen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0304-3940(93)90303-3en_US
dc.identifier.pmid7687046-
dc.identifier.scopuseid_2-s2.0-0027157901en_US
dc.identifier.volume153en_US
dc.identifier.issue2en_US
dc.identifier.spage121en_US
dc.identifier.epage124en_US
dc.identifier.isiWOS:A1993LB60600001-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridLi, L=9038682000en_US

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