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Article: Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry

TitleExpression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry
Authors
Issue Date1993
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 1993, v. 120 n. 2, p. 153-159 How to Cite?
AbstractRecent studies have implicated nitric oxide (NO) in several mechanisms related to neuronal degeneration and synaptic plasticity. In the present study, two models of traumatic neuronal injury were used to examine the expression of NOS following neuronal injury and its relationship to axonal sprouting and neuronal degeneration. It was found that NOS is induced in a week of axonal injury in neurons that are normally NOS-negative. Spinal motoneurons express the enzyme after ventral root avulsion, but not after ventral root transection. Neurons of the nucleus dorsalis of the spinal cord express NOS after ipsilateral spinal cord hemisection. These two models provide information about the time course of NOS expression in injured neurons and the opportunity in future studies to determine the role of NOS and its product, NO, in CNS injury. Observations from the present study suggest that early NOS expression seems to be associated with axonal sprouting and growth. Interestingly, though, the neurons expressing lesion-induced NOS ultimately die. Whether NOS expression in these cells is related to their death is currently under investigation.
Persistent Identifierhttp://hdl.handle.net/10722/149527
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-06-26T05:54:50Z-
dc.date.available2012-06-26T05:54:50Z-
dc.date.issued1993en_US
dc.identifier.citationExperimental Neurology, 1993, v. 120 n. 2, p. 153-159en_US
dc.identifier.issn0014-4886en_US
dc.identifier.urihttp://hdl.handle.net/10722/149527-
dc.description.abstractRecent studies have implicated nitric oxide (NO) in several mechanisms related to neuronal degeneration and synaptic plasticity. In the present study, two models of traumatic neuronal injury were used to examine the expression of NOS following neuronal injury and its relationship to axonal sprouting and neuronal degeneration. It was found that NOS is induced in a week of axonal injury in neurons that are normally NOS-negative. Spinal motoneurons express the enzyme after ventral root avulsion, but not after ventral root transection. Neurons of the nucleus dorsalis of the spinal cord express NOS after ipsilateral spinal cord hemisection. These two models provide information about the time course of NOS expression in injured neurons and the opportunity in future studies to determine the role of NOS and its product, NO, in CNS injury. Observations from the present study suggest that early NOS expression seems to be associated with axonal sprouting and growth. Interestingly, though, the neurons expressing lesion-induced NOS ultimately die. Whether NOS expression in these cells is related to their death is currently under investigation.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_US
dc.relation.ispartofExperimental Neurologyen_US
dc.subject.meshAmino Acid Oxidoreductases - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshLaminectomyen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Neurons - Enzymology - Pathologyen_US
dc.subject.meshNadph Dehydrogenase - Metabolismen_US
dc.subject.meshNeurons - Enzymology - Pathologyen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSpinal Cord - Enzymology - Pathologyen_US
dc.subject.meshSpinal Cord Injuries - Enzymology - Pathology - Physiopathologyen_US
dc.subject.meshTime Factorsen_US
dc.titleExpression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistryen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/exnr.1993.1050en_US
dc.identifier.pmid7684000en_US
dc.identifier.scopuseid_2-s2.0-0027154946en_US
dc.identifier.volume120en_US
dc.identifier.issue2en_US
dc.identifier.spage153en_US
dc.identifier.epage159en_US
dc.identifier.isiWOS:A1993LE43800001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, W=7407081122en_US

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