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Article: Unifocal origin of advanced human epithelial ovarian cancers

TitleUnifocal origin of advanced human epithelial ovarian cancers
Authors
Issue Date1992
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1992, v. 52 n. 18, p. 5119-5122 How to Cite?
AbstractOvarian cancers are often diagnosed at a late stage, after the cancer cells have spread to extraovarian sites. Failure to diagnose these tumors earlier may reflect the lack of symptoms and the need for a sensitive, reliable screening test. Alternatively, this can be explained by the hypothesis that some of the extraovarian tumor implants do not represent metastatic spread from the primary cancer but instead are multiple primary tumors developing simultaneously in the peritoneal epithelium. If this is the case, some patients with advanced ovarian cancer may never have had a stage I disease, making early detection theoretically impossible. In this study, we examined the mutational pattern of the p53 gene in 9 patients with epithelial ovarian cancers using tissue collected from different sites within the same patient. In all 9 cases, the mutational pattern of the p53 gene was identical in cancer cells from different sites within the same patient, strongly suggesting that these ovarian tumors were of unifocal origin and that cancer tissues collected from different sites are derived from a single origin.
Persistent Identifierhttp://hdl.handle.net/10722/149523
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMok, CHen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorKnapp, RCen_US
dc.contributor.authorFishbaugh, PMen_US
dc.contributor.authorLau, CCen_US
dc.date.accessioned2012-06-26T05:54:48Z-
dc.date.available2012-06-26T05:54:48Z-
dc.date.issued1992en_US
dc.identifier.citationCancer Research, 1992, v. 52 n. 18, p. 5119-5122en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/149523-
dc.description.abstractOvarian cancers are often diagnosed at a late stage, after the cancer cells have spread to extraovarian sites. Failure to diagnose these tumors earlier may reflect the lack of symptoms and the need for a sensitive, reliable screening test. Alternatively, this can be explained by the hypothesis that some of the extraovarian tumor implants do not represent metastatic spread from the primary cancer but instead are multiple primary tumors developing simultaneously in the peritoneal epithelium. If this is the case, some patients with advanced ovarian cancer may never have had a stage I disease, making early detection theoretically impossible. In this study, we examined the mutational pattern of the p53 gene in 9 patients with epithelial ovarian cancers using tissue collected from different sites within the same patient. In all 9 cases, the mutational pattern of the p53 gene was identical in cancer cells from different sites within the same patient, strongly suggesting that these ovarian tumors were of unifocal origin and that cancer tissues collected from different sites are derived from a single origin.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAdenocarcinoma - Genetics - Pathologyen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, P53en_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMutationen_US
dc.subject.meshNeoplastic Stem Cellsen_US
dc.subject.meshOvarian Neoplasms - Genetics - Pathologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.titleUnifocal origin of advanced human epithelial ovarian cancersen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1516069-
dc.identifier.scopuseid_2-s2.0-0026786662en_US
dc.identifier.volume52en_US
dc.identifier.issue18en_US
dc.identifier.spage5119en_US
dc.identifier.epage5122en_US
dc.identifier.isiWOS:A1992JN05300045-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMok, CH=7102344233en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridKnapp, RC=7201853287en_US
dc.identifier.scopusauthoridFishbaugh, PM=6507784159en_US
dc.identifier.scopusauthoridLau, CC=7401968381en_US

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