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Article: Involvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumors

TitleInvolvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumors
Authors
Issue Date1991
Citation
Anticancer Research, 1991, v. 11 n. 6, p. 1975-1982 How to Cite?
AbstractPrevious reports have shown that one copy of the chromosome 17 was frequently lost in human ovarian cancers (1). The position of the allelic deletion has not been mapped and involvement of p53 gene has not been determined. In this study we have shown that in human ovarian carcinoma the commonest region of allelic loss in chromosome 17p is 17p 13.3 (65%) and 17p13.1 (63.7%) and p53 gene was usually involved in the deletion (66.7%; 6 out of 9 informative cases). Allelic loss was also observed at region 17pl2 -11.1 but at a lower frequency (38.6% to 37.5%). The pattern of allelic loss of p53 gene was consistent in both primary and secondary metastatic tumors of the same patient. No gross rearrangement of p53 was however observed at the remaining allele using Southern blot analysis. Allelic loss of p53 gene was closely associated with 17p 13.3 the terminal portion of chromosome 17p. The high frequency of allelic loss of p53 gene in ovarian carcinomas conformed with recent findings in cancers of colon breast lung and brain suggesting inactivation of p53 gene play a rate limiting step in pathogenesis of human malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/149516
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_US
dc.contributor.authorMok, CHen_US
dc.contributor.authorOike, Ken_US
dc.contributor.authorMuto, Men_US
dc.contributor.authorGoodman, HMen_US
dc.contributor.authorSheets, EEen_US
dc.contributor.authorBerkowitz, RSen_US
dc.contributor.authorKnapp, RCen_US
dc.contributor.authorLau, CCen_US
dc.date.accessioned2012-06-26T05:54:44Z-
dc.date.available2012-06-26T05:54:44Z-
dc.date.issued1991en_US
dc.identifier.citationAnticancer Research, 1991, v. 11 n. 6, p. 1975-1982en_US
dc.identifier.issn0250-7005en_US
dc.identifier.urihttp://hdl.handle.net/10722/149516-
dc.description.abstractPrevious reports have shown that one copy of the chromosome 17 was frequently lost in human ovarian cancers (1). The position of the allelic deletion has not been mapped and involvement of p53 gene has not been determined. In this study we have shown that in human ovarian carcinoma the commonest region of allelic loss in chromosome 17p is 17p 13.3 (65%) and 17p13.1 (63.7%) and p53 gene was usually involved in the deletion (66.7%; 6 out of 9 informative cases). Allelic loss was also observed at region 17pl2 -11.1 but at a lower frequency (38.6% to 37.5%). The pattern of allelic loss of p53 gene was consistent in both primary and secondary metastatic tumors of the same patient. No gross rearrangement of p53 was however observed at the remaining allele using Southern blot analysis. Allelic loss of p53 gene was closely associated with 17p 13.3 the terminal portion of chromosome 17p. The high frequency of allelic loss of p53 gene in ovarian carcinomas conformed with recent findings in cancers of colon breast lung and brain suggesting inactivation of p53 gene play a rate limiting step in pathogenesis of human malignancies.en_US
dc.languageengen_US
dc.relation.ispartofAnticancer Researchen_US
dc.subject.meshAllelesen_US
dc.subject.meshChromosome Bandingen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshDna Probesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, P53 - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshOvarian Neoplasms - Genetics - Pathologyen_US
dc.titleInvolvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumorsen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1776830-
dc.identifier.scopuseid_2-s2.0-0026353646en_US
dc.identifier.volume11en_US
dc.identifier.issue6en_US
dc.identifier.spage1975en_US
dc.identifier.epage1982en_US
dc.identifier.isiWOS:A1991HB24400005-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridMok, CH=7102344233en_US
dc.identifier.scopusauthoridOike, K=6602813848en_US
dc.identifier.scopusauthoridMuto, M=7102795179en_US
dc.identifier.scopusauthoridGoodman, HM=55207871500en_US
dc.identifier.scopusauthoridSheets, EE=7003289543en_US
dc.identifier.scopusauthoridBerkowitz, RS=7201352221en_US
dc.identifier.scopusauthoridKnapp, RC=7201853287en_US
dc.identifier.scopusauthoridLau, CC=7401968381en_US

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