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Article: Regulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchyme

TitleRegulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchyme
Authors
Issue Date1991
Citation
Cancer Surveys, 1991, v. 11, p. 73-90 How to Cite?
AbstractSince adult epithelial cells from the urogenital tract are unquestionably capable of expressing alternative phenotypes when induced by embryonic or neonatal mesenchymes, we examined the effect of certain inductive mesenchymes on the differentiation and growth of the DT by growing 0.5 mm3 fragments of the DT in association with mesenchyme from various embryonic and neonatal rat organ rudiments. Whereas grafts of DT alone contained narrow ducts lined with undifferentiated epithelial cells characteristic of the DT, the DT derived epithelium of UGM + DT, SVM + DT or BUG-M + DT recombinations differentiated into tall columnar secretory epithelial cells organized into large cystic ducts. These mesenchyme induced changes in histodifferentiation of the DT cells were coupled to a loss of tumorigenesis since the mesenchyme induced highly differentiated DT cells never formed tumours. This reduction in growth rate and loss in tumorigenesis of mesenchyme induced DT epithelial cells was accompanied by a reduction in [3H]thymidine labelling index and the expression of a secretory phenotype as demonstrated by both light microscopy and electron microscopy. These findings demonstrate that the connective tissue environment can have profound regulative effects on both normal and neoplastic epithelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/149514
ISSN
2001 Impact Factor: 3.0
2001 SCImago Journal Rankings: 1.050
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCunha, GRen_US
dc.contributor.authorHayashi, Nen_US
dc.contributor.authorWong, YCen_US
dc.date.accessioned2012-06-26T05:54:43Z-
dc.date.available2012-06-26T05:54:43Z-
dc.date.issued1991en_US
dc.identifier.citationCancer Surveys, 1991, v. 11, p. 73-90en_US
dc.identifier.issn0261-2429en_US
dc.identifier.urihttp://hdl.handle.net/10722/149514-
dc.description.abstractSince adult epithelial cells from the urogenital tract are unquestionably capable of expressing alternative phenotypes when induced by embryonic or neonatal mesenchymes, we examined the effect of certain inductive mesenchymes on the differentiation and growth of the DT by growing 0.5 mm3 fragments of the DT in association with mesenchyme from various embryonic and neonatal rat organ rudiments. Whereas grafts of DT alone contained narrow ducts lined with undifferentiated epithelial cells characteristic of the DT, the DT derived epithelium of UGM + DT, SVM + DT or BUG-M + DT recombinations differentiated into tall columnar secretory epithelial cells organized into large cystic ducts. These mesenchyme induced changes in histodifferentiation of the DT cells were coupled to a loss of tumorigenesis since the mesenchyme induced highly differentiated DT cells never formed tumours. This reduction in growth rate and loss in tumorigenesis of mesenchyme induced DT epithelial cells was accompanied by a reduction in [3H]thymidine labelling index and the expression of a secretory phenotype as demonstrated by both light microscopy and electron microscopy. These findings demonstrate that the connective tissue environment can have profound regulative effects on both normal and neoplastic epithelial cells.en_US
dc.languageengen_US
dc.relation.ispartofCancer Surveysen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Communicationen_US
dc.subject.meshCell Differentiation - Physiologyen_US
dc.subject.meshCell Division - Physiologyen_US
dc.subject.meshCell Transformation, Neoplasticen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMesoderm - Physiologyen_US
dc.subject.meshProstatic Neoplasms - Physiopathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshUrogenital System - Cytologyen_US
dc.titleRegulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchymeen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1841758-
dc.identifier.scopuseid_2-s2.0-0026320504en_US
dc.identifier.volume11en_US
dc.identifier.spage73en_US
dc.identifier.epage90en_US
dc.identifier.isiWOS:A1991HQ11500008-
dc.identifier.scopusauthoridCunha, GR=7103155694en_US
dc.identifier.scopusauthoridHayashi, N=36078182000en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US

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