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Article: Morphometric and stereological study of the glandular epithelium of the lateral prostate of the intact and castrated guinea pig

TitleMorphometric and stereological study of the glandular epithelium of the lateral prostate of the intact and castrated guinea pig
Authors
Issue Date1991
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34304
Citation
Prostate, 1991, v. 19 n. 1, p. 1-22 How to Cite?
AbstractThe glandular epithelium of the lateral prostate of the guinea pig was described within the framework of a morphometric model in terms of relative densities and absolute dimensions. A combination of direct measurement and point and intersection counting techniques was used. The quantitative data generated in the intact animals were compared with those of castrated controls. Castration was accompanied by a significant decrease in height of the glandular epithelium and in sizes of secretory and basal cells and their corresponding nuclei. On a per cell basis, significant decreases in total volume and surface area of granular endoplasmic reticulum were detected after castration. This was accompanied by a significant reduction in the total volume of Golgi cisternae. The total volume, surface area, and number of highly electron-dense and clear granules decreased significantly compared with the intact control animals. However, no significant changes in these parameters of low electron-dense granules were found. Significant reductions in the total volume and surface area of condensing granules, lysosomes, and mitochondria, but not their number, were detected. The average sizes of condensing granules, secretory granules, lysosomes, and mitochondria were decreased significantly after castration. The present study showed that the alterations in the secretory function of the secretory cells of the lateral prostate was reflected by the quantitative changes in granular endoplasmic reticulum, Golgi complexes, and secretory granules on a per cell basis. The data generated in the present study will serve as a baseline for further studies of the lateral prostate of the guinea pig.
Persistent Identifierhttp://hdl.handle.net/10722/149512
ISSN
2015 Impact Factor: 3.778
2015 SCImago Journal Rankings: 1.477
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, CCen_US
dc.contributor.authorWong, YCen_US
dc.contributor.authorWhite, FHen_US
dc.contributor.authorFowler, JPen_US
dc.date.accessioned2012-06-26T05:54:42Z-
dc.date.available2012-06-26T05:54:42Z-
dc.date.issued1991en_US
dc.identifier.citationProstate, 1991, v. 19 n. 1, p. 1-22en_US
dc.identifier.issn0270-4137en_US
dc.identifier.urihttp://hdl.handle.net/10722/149512-
dc.description.abstractThe glandular epithelium of the lateral prostate of the guinea pig was described within the framework of a morphometric model in terms of relative densities and absolute dimensions. A combination of direct measurement and point and intersection counting techniques was used. The quantitative data generated in the intact animals were compared with those of castrated controls. Castration was accompanied by a significant decrease in height of the glandular epithelium and in sizes of secretory and basal cells and their corresponding nuclei. On a per cell basis, significant decreases in total volume and surface area of granular endoplasmic reticulum were detected after castration. This was accompanied by a significant reduction in the total volume of Golgi cisternae. The total volume, surface area, and number of highly electron-dense and clear granules decreased significantly compared with the intact control animals. However, no significant changes in these parameters of low electron-dense granules were found. Significant reductions in the total volume and surface area of condensing granules, lysosomes, and mitochondria, but not their number, were detected. The average sizes of condensing granules, secretory granules, lysosomes, and mitochondria were decreased significantly after castration. The present study showed that the alterations in the secretory function of the secretory cells of the lateral prostate was reflected by the quantitative changes in granular endoplasmic reticulum, Golgi complexes, and secretory granules on a per cell basis. The data generated in the present study will serve as a baseline for further studies of the lateral prostate of the guinea pig.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34304en_US
dc.relation.ispartofProstateen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCytoplasm - Ultrastructureen_US
dc.subject.meshEpithelium - Ultrastructureen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMaleen_US
dc.subject.meshOrchiectomyen_US
dc.subject.meshOrganelles - Ultrastructureen_US
dc.subject.meshProstate - Anatomy & Histology - Cytology - Ultrastructureen_US
dc.titleMorphometric and stereological study of the glandular epithelium of the lateral prostate of the intact and castrated guinea pigen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pros.2990190102en_US
dc.identifier.pmid1876534-
dc.identifier.scopuseid_2-s2.0-0025947854en_US
dc.identifier.volume19en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage22en_US
dc.identifier.isiWOS:A1991GC02200001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTam, CC=7201442974en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridWhite, FH=7202578907en_US
dc.identifier.scopusauthoridFowler, JP=7402371064en_US

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