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Article: Ultrastructural study of the effects of 17β-oestradiol on the lateral prostate and seminal vesicle of the castrated guinea pig

TitleUltrastructural study of the effects of 17β-oestradiol on the lateral prostate and seminal vesicle of the castrated guinea pig
Authors
Issue Date1991
Citation
Acta Anatomica, 1991, v. 141 n. 1, p. 51-62 How to Cite?
AbstractAdministration of oestradiol to castrated animals induced hypertrophy of the secretory cells in the lateral prostate and seminal vesicle. In the lateral prostate, increases in the number of small highly electron-dense granules, multivesicular bodies and intercellular spaces were the prevailing effects 2 weeks after oestradiol treatment. There was also an apparent increase in the amount of cytokeratin intermediate filaments. Prolonged oestradiol administration for 4 weeks showed no appreciable changes in the glandular epithelium when compared with 2-week treatment. However, an increase in the thickness of the fibromuscular layer was observed. In the seminal vesicle, basal cell hyperplasia was associated with a concurrent increase in the size of intercellular spaces 2 weeks after oestradiol administration. There were also apparent increases in the volume of the lamina propria and in the number of stromal cells. An apparent increase in the density of collagen fibres in the stroma was observed 2 and 4 weeks after oestradiol administration. In conclusion, the responses of the epithelium of the lateral prostate and seminal vesicle to a pharmacological dose of oestradiol are different. Prolonged oestradiol administration exerts a more prominent effect on the smooth muscle in the lateral prostate but not in the seminal vesicle. The effects of oestradiol may be mediated directly or indirectly through the other hormones.
Persistent Identifierhttp://hdl.handle.net/10722/149509
ISSN
2000 Impact Factor: 2.435
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, CCen_US
dc.contributor.authorWong, YCen_US
dc.date.accessioned2012-06-26T05:54:40Z-
dc.date.available2012-06-26T05:54:40Z-
dc.date.issued1991en_US
dc.identifier.citationActa Anatomica, 1991, v. 141 n. 1, p. 51-62en_US
dc.identifier.issn0001-5180en_US
dc.identifier.urihttp://hdl.handle.net/10722/149509-
dc.description.abstractAdministration of oestradiol to castrated animals induced hypertrophy of the secretory cells in the lateral prostate and seminal vesicle. In the lateral prostate, increases in the number of small highly electron-dense granules, multivesicular bodies and intercellular spaces were the prevailing effects 2 weeks after oestradiol treatment. There was also an apparent increase in the amount of cytokeratin intermediate filaments. Prolonged oestradiol administration for 4 weeks showed no appreciable changes in the glandular epithelium when compared with 2-week treatment. However, an increase in the thickness of the fibromuscular layer was observed. In the seminal vesicle, basal cell hyperplasia was associated with a concurrent increase in the size of intercellular spaces 2 weeks after oestradiol administration. There were also apparent increases in the volume of the lamina propria and in the number of stromal cells. An apparent increase in the density of collagen fibres in the stroma was observed 2 and 4 weeks after oestradiol administration. In conclusion, the responses of the epithelium of the lateral prostate and seminal vesicle to a pharmacological dose of oestradiol are different. Prolonged oestradiol administration exerts a more prominent effect on the smooth muscle in the lateral prostate but not in the seminal vesicle. The effects of oestradiol may be mediated directly or indirectly through the other hormones.en_US
dc.languageengen_US
dc.relation.ispartofActa Anatomicaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCastrationen_US
dc.subject.meshEstradiol - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHyperplasia - Chemically Induced - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshProstate - Drug Effects - Ultrastructureen_US
dc.subject.meshSeminal Vesicles - Drug Effects - Ultrastructureen_US
dc.titleUltrastructural study of the effects of 17β-oestradiol on the lateral prostate and seminal vesicle of the castrated guinea pigen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1950420-
dc.identifier.scopuseid_2-s2.0-0025822993en_US
dc.identifier.volume141en_US
dc.identifier.issue1en_US
dc.identifier.spage51en_US
dc.identifier.epage62en_US
dc.identifier.isiWOS:A1991GA69500010-
dc.identifier.scopusauthoridTam, CC=7201442974en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US

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