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Article: Expression of a new surface membrane antigen (SQM1) in tumor cells cultured in media with different calcium ion levels

TitleExpression of a new surface membrane antigen (SQM1) in tumor cells cultured in media with different calcium ion levels
Authors
Issue Date1991
Citation
Anticancer Research, 1991, v. 11 n. 3, p. 1205-1213 How to Cite?
AbstractTerminal differentiation is usually achieved in normal as well as transformed squamous epithelial cells when cultured. On the other hand, tumor cells at various differentiation stages and with different biological characteristics comprise the heterogeneous properties of tumors which have been one of the barriers to effective treatments. Recently, a surface membrane protein has been reported in squamous cell carcinomas of the head and neck, which is recognized by a murine monoclonal antibody, SQM1. This glycoprotein was further suggested to be related to squamous cell differentiation and intercellular adhesion. In a recent study, the esophageal carcinoma cells of EC/CUHK2 cell line were induced to various differentiation stages as evidenced by the increasing amount of intracellular desmosomes and tonofilaments and greater binding ratios of cytokeratin and involucrin antibodies than in those cells that maintained lower calcium ion concentrations. The expression of SQM1 antigen was found to increase in intensity when the tumor cells were cultured in moderate to high calcium ion levels for 10 to 15 hours when the differentiation patterns were beginning to appear. The intensity declined gradually thereafter. Thus SQMI protein might be related to the stage when the cells started committing with squamous differentiation.
Persistent Identifierhttp://hdl.handle.net/10722/149508
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChew, ECen_US
dc.contributor.authorYam, HFen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorBernal, SDen_US
dc.date.accessioned2012-06-26T05:54:39Z-
dc.date.available2012-06-26T05:54:39Z-
dc.date.issued1991en_US
dc.identifier.citationAnticancer Research, 1991, v. 11 n. 3, p. 1205-1213en_US
dc.identifier.issn0250-7005en_US
dc.identifier.urihttp://hdl.handle.net/10722/149508-
dc.description.abstractTerminal differentiation is usually achieved in normal as well as transformed squamous epithelial cells when cultured. On the other hand, tumor cells at various differentiation stages and with different biological characteristics comprise the heterogeneous properties of tumors which have been one of the barriers to effective treatments. Recently, a surface membrane protein has been reported in squamous cell carcinomas of the head and neck, which is recognized by a murine monoclonal antibody, SQM1. This glycoprotein was further suggested to be related to squamous cell differentiation and intercellular adhesion. In a recent study, the esophageal carcinoma cells of EC/CUHK2 cell line were induced to various differentiation stages as evidenced by the increasing amount of intracellular desmosomes and tonofilaments and greater binding ratios of cytokeratin and involucrin antibodies than in those cells that maintained lower calcium ion concentrations. The expression of SQM1 antigen was found to increase in intensity when the tumor cells were cultured in moderate to high calcium ion levels for 10 to 15 hours when the differentiation patterns were beginning to appear. The intensity declined gradually thereafter. Thus SQMI protein might be related to the stage when the cells started committing with squamous differentiation.en_US
dc.languageengen_US
dc.relation.ispartofAnticancer Researchen_US
dc.subject.meshAntibodies, Monoclonal - Diagnostic Useen_US
dc.subject.meshAntigens, Neoplasm - Analysis - Physiologyen_US
dc.subject.meshAntigens, Surface - Analysis - Physiologyen_US
dc.subject.meshCalcium - Pharmacologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Immunologyen_US
dc.subject.meshCulture Mediaen_US
dc.subject.meshEsophageal Neoplasms - Immunologyen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleExpression of a new surface membrane antigen (SQM1) in tumor cells cultured in media with different calcium ion levelsen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1888151-
dc.identifier.scopuseid_2-s2.0-0025776818en_US
dc.identifier.volume11en_US
dc.identifier.issue3en_US
dc.identifier.spage1205en_US
dc.identifier.epage1213en_US
dc.identifier.isiWOS:A1991GD36600026-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridChew, EC=7102013767en_US
dc.identifier.scopusauthoridYam, HF=6603358342en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridBernal, SD=7006000150en_US

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