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Article: Morphological changes of retinal ganglion cells regenerating axons along peripheral nerve grafts: A Lucifer yellow and silver staining study

TitleMorphological changes of retinal ganglion cells regenerating axons along peripheral nerve grafts: A Lucifer yellow and silver staining study
Authors
KeywordsLucifer Yellow
Peripheral Nerve Graft
Retinal Ganglion Cell
Silver Staining
Issue Date1991
PublisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/09226028.php
Citation
Restorative Neurology And Neuroscience, 1991, v. 3 n. 5, p. 235-246 How to Cite?
AbstractThe morphology of the retinal ganglion cells (RGCs) with their axons regenerating along a peripheral nerve graft at different post-grafting periods was studied by the intracellular injection of Lucifer yellow (LY) and silver staining methods. Several morphological features which were observed on developing RGCs, but not mature RGCs, have also been observed in the regenerating RGCs studied by the intracellular injection of LY. These morphological features observed on the regenerating RGCs included intraretinal axonal branches and collaterals, spine-like processes on the dendrites and soma, and short processes on the soma. These results suggest that damaged mammalian RGCs may be able to recapitulate certain cellular events which occur during normal development provided the regenerating cells are given the proper stimulus and a favorable environment for regrowth. From the results of both LY injection and silver staining experiments, it was found that the dendrites of the regenerating RGCs were, in general, much simpler than that of control Type I RGCs. However, regenerating RGCs with different degree of dendritic complexity could be observed in all post-grafting periods studied, and the dendritic complexity seems to decrease continuously with the increase in the post-grafting time. These results suggest that the ability to regenerate an axon is not closely related to dendritic responses and the peripheral nerve does not seem to be able to prevent the deterioration and retraction of the dendrites.
Persistent Identifierhttp://hdl.handle.net/10722/149507
ISSN
2015 Impact Factor: 2.661
2015 SCImago Journal Rankings: 1.181

 

DC FieldValueLanguage
dc.contributor.authorLau, KCen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorCho, EYPen_US
dc.date.accessioned2012-06-26T05:54:39Z-
dc.date.available2012-06-26T05:54:39Z-
dc.date.issued1991en_US
dc.identifier.citationRestorative Neurology And Neuroscience, 1991, v. 3 n. 5, p. 235-246en_US
dc.identifier.issn0922-6028en_US
dc.identifier.urihttp://hdl.handle.net/10722/149507-
dc.description.abstractThe morphology of the retinal ganglion cells (RGCs) with their axons regenerating along a peripheral nerve graft at different post-grafting periods was studied by the intracellular injection of Lucifer yellow (LY) and silver staining methods. Several morphological features which were observed on developing RGCs, but not mature RGCs, have also been observed in the regenerating RGCs studied by the intracellular injection of LY. These morphological features observed on the regenerating RGCs included intraretinal axonal branches and collaterals, spine-like processes on the dendrites and soma, and short processes on the soma. These results suggest that damaged mammalian RGCs may be able to recapitulate certain cellular events which occur during normal development provided the regenerating cells are given the proper stimulus and a favorable environment for regrowth. From the results of both LY injection and silver staining experiments, it was found that the dendrites of the regenerating RGCs were, in general, much simpler than that of control Type I RGCs. However, regenerating RGCs with different degree of dendritic complexity could be observed in all post-grafting periods studied, and the dendritic complexity seems to decrease continuously with the increase in the post-grafting time. These results suggest that the ability to regenerate an axon is not closely related to dendritic responses and the peripheral nerve does not seem to be able to prevent the deterioration and retraction of the dendrites.en_US
dc.languageengen_US
dc.publisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/09226028.phpen_US
dc.relation.ispartofRestorative Neurology and Neuroscienceen_US
dc.subjectLucifer Yellowen_US
dc.subjectPeripheral Nerve Graften_US
dc.subjectRetinal Ganglion Cellen_US
dc.subjectSilver Stainingen_US
dc.titleMorphological changes of retinal ganglion cells regenerating axons along peripheral nerve grafts: A Lucifer yellow and silver staining studyen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0025721822en_US
dc.identifier.hkuros97740-
dc.identifier.volume3en_US
dc.identifier.issue5en_US
dc.identifier.spage235en_US
dc.identifier.epage246en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLau, KC=16407204200en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridCho, EYP=7202649985en_US

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