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Article: Toxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines

TitleToxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines
Authors
Issue Date1990
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/toxicon
Citation
Toxicon, 1990, v. 28 n. 10, p. 1183-1192 How to Cite?
AbstractTrichosanthin and alpha-momorcharin are abortifacient proteins extracted from Chinese medicinal herbs. Study of their in vitro cytotoxicities showed that the two proteins selectively injured choriocarcinoma and melanoma cells. Hepatoma cells represented the most resistant cell line among the various cell lines investigated. Cytotoxicity profiles of trichosanthin and alpha-momorcharin differed from those of anti-cancer drugs which interfere with DNA metabolism such as cisplatin, methotrexate and 5-fluorouracil. Radioactive precursor incorporation studies suggested that the two abortifacient proteins inhibited cellular protein synthesis. The marked decrease in secretion of human chorionic gonadotropin and progesterone by choriocarcinoma cells after treatment with the proteins could be attributed mainly to loss of cells.
Persistent Identifierhttp://hdl.handle.net/10722/149502
ISSN
2015 Impact Factor: 2.309
2015 SCImago Journal Rankings: 0.889
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_US
dc.contributor.authorNg, TBen_US
dc.contributor.authorYeung, HWen_US
dc.date.accessioned2012-06-26T05:54:35Z-
dc.date.available2012-06-26T05:54:35Z-
dc.date.issued1990en_US
dc.identifier.citationToxicon, 1990, v. 28 n. 10, p. 1183-1192en_US
dc.identifier.issn0041-0101en_US
dc.identifier.urihttp://hdl.handle.net/10722/149502-
dc.description.abstractTrichosanthin and alpha-momorcharin are abortifacient proteins extracted from Chinese medicinal herbs. Study of their in vitro cytotoxicities showed that the two proteins selectively injured choriocarcinoma and melanoma cells. Hepatoma cells represented the most resistant cell line among the various cell lines investigated. Cytotoxicity profiles of trichosanthin and alpha-momorcharin differed from those of anti-cancer drugs which interfere with DNA metabolism such as cisplatin, methotrexate and 5-fluorouracil. Radioactive precursor incorporation studies suggested that the two abortifacient proteins inhibited cellular protein synthesis. The marked decrease in secretion of human chorionic gonadotropin and progesterone by choriocarcinoma cells after treatment with the proteins could be attributed mainly to loss of cells.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/toxiconen_US
dc.relation.ispartofToxiconen_US
dc.subject.meshAbortifacient Agents, Nonsteroidal - Toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinoma, Hepatocellularen_US
dc.subject.meshCarcinoma, Squamous Cellen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshChoriocarcinomaen_US
dc.subject.meshChorionic Gonadotropin - Secretionen_US
dc.subject.meshCisplatin - Toxicityen_US
dc.subject.meshDrugs, Chinese Herbal - Toxicityen_US
dc.subject.meshFluorouracil - Toxicityen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasmsen_US
dc.subject.meshMelanomaen_US
dc.subject.meshMethotrexate - Toxicityen_US
dc.subject.meshPlant Proteins - Toxicityen_US
dc.subject.meshProgesterone - Secretionen_US
dc.subject.meshRibosomal Proteinsen_US
dc.subject.meshRibosome Inactivating Proteinsen_US
dc.subject.meshTrichosanthin - Toxicityen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleToxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell linesen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0041-0101(90)90118-Qen_US
dc.identifier.pmid2175958-
dc.identifier.scopuseid_2-s2.0-0025173671en_US
dc.identifier.volume28en_US
dc.identifier.issue10en_US
dc.identifier.spage1183en_US
dc.identifier.epage1192en_US
dc.identifier.isiWOS:A1990EB81500009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridNg, TB=36041665600en_US
dc.identifier.scopusauthoridYeung, HW=24431091900en_US

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