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Article: cDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cells

TitlecDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cells
Authors
Issue Date1990
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 1990, v. 166 n. 2, p. 984-992 How to Cite?
AbstractA novel protein (SQM1 protein) present in human squamous epithelial cells has been found to be involved in cell adhesion in squamous epithelial cells, endothelial cells and extracellular matrix proteins. The corresponding cDNA that encodes a 135-residue polypeptide has been isolated. Sequence analysis indicates that the encoded polypeptide is distinct yet related to the β subunit of integrins. A new sequence motif consisting of a heptadic repeat of positively-charged residues present in the polypeptide has been identified and is proposed to be important in protein-protein interaction. These results suggest that SQM1 protein, a new cell adhesion molecule expressed in squamous epithelial cells, may play an important role in tumor metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/149501
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorKakefuda, Men_US
dc.contributor.authorBernal, SDen_US
dc.date.accessioned2012-06-26T05:54:35Z-
dc.date.available2012-06-26T05:54:35Z-
dc.date.issued1990en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 1990, v. 166 n. 2, p. 984-992en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/149501-
dc.description.abstractA novel protein (SQM1 protein) present in human squamous epithelial cells has been found to be involved in cell adhesion in squamous epithelial cells, endothelial cells and extracellular matrix proteins. The corresponding cDNA that encodes a 135-residue polypeptide has been isolated. Sequence analysis indicates that the encoded polypeptide is distinct yet related to the β subunit of integrins. A new sequence motif consisting of a heptadic repeat of positively-charged residues present in the polypeptide has been identified and is proposed to be important in protein-protein interaction. These results suggest that SQM1 protein, a new cell adhesion molecule expressed in squamous epithelial cells, may play an important role in tumor metastasis.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshCell Adhesion Molecules - Genetics - Immunologyen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshDna - Geneticsen_US
dc.subject.meshEpithelium - Analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNadh, Nadph Oxidoreductasesen_US
dc.subject.meshNeoplasm Proteins - Genetics - Immunologyen_US
dc.subject.meshProtein Biosynthesisen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titlecDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cellsen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0006-291X(90)90908-6en_US
dc.identifier.pmid2302251-
dc.identifier.scopuseid_2-s2.0-0025095483en_US
dc.identifier.volume166en_US
dc.identifier.issue2en_US
dc.identifier.spage984en_US
dc.identifier.epage992en_US
dc.identifier.isiWOS:A1990CL74100065-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, YC=7403041461en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridKakefuda, M=6506142302en_US
dc.identifier.scopusauthoridBernal, SD=7006000150en_US

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