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Article: The effect of β-endorphin on rat oocyte maturation in vitro

TitleThe effect of β-endorphin on rat oocyte maturation in vitro
Authors
Issue Date1990
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce
Citation
Molecular And Cellular Endocrinology, 1990, v. 68 n. 2-3, p. 181-185 How to Cite?
AbstractCumulus enclosed or denuded oocytes obtained from ovaries of 25- to 27-day Sprague-Dawley rats underwent spontaneous germinal vesicle breakdown (GVBD) when cultured for 6 h in Krebs-Ringer's buffered solution (KRBS). This spontaneous division was found to be inhibited by adding β-endorphin to the culture system and the inhibition was dose dependent, ranging from 200 to 800 pg/ml KRBS. Naloxone, a potent opioid antagonist without any agonistic action, did not stimulate spontaneous GVBD when added to the KRBS at doses ranging from 80 to 120 pg/ml. However, by adding 80 pg/ml naloxone to the culture system containing 600 pg/ml β-endorphin, the inhibitory effect of β-endorphin on spontaneous GVBD could be reversed completely.
Persistent Identifierhttp://hdl.handle.net/10722/149500
ISSN
2015 Impact Factor: 3.859
2015 SCImago Journal Rankings: 2.116

 

DC FieldValueLanguage
dc.contributor.authorO, WSen_US
dc.date.accessioned2012-06-26T05:54:34Z-
dc.date.available2012-06-26T05:54:34Z-
dc.date.issued1990en_US
dc.identifier.citationMolecular And Cellular Endocrinology, 1990, v. 68 n. 2-3, p. 181-185en_US
dc.identifier.issn0303-7207en_US
dc.identifier.urihttp://hdl.handle.net/10722/149500-
dc.description.abstractCumulus enclosed or denuded oocytes obtained from ovaries of 25- to 27-day Sprague-Dawley rats underwent spontaneous germinal vesicle breakdown (GVBD) when cultured for 6 h in Krebs-Ringer's buffered solution (KRBS). This spontaneous division was found to be inhibited by adding β-endorphin to the culture system and the inhibition was dose dependent, ranging from 200 to 800 pg/ml KRBS. Naloxone, a potent opioid antagonist without any agonistic action, did not stimulate spontaneous GVBD when added to the KRBS at doses ranging from 80 to 120 pg/ml. However, by adding 80 pg/ml naloxone to the culture system containing 600 pg/ml β-endorphin, the inhibitory effect of β-endorphin on spontaneous GVBD could be reversed completely.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mceen_US
dc.relation.ispartofMolecular and Cellular Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshMeiosis - Drug Effectsen_US
dc.subject.meshNaloxone - Pharmacologyen_US
dc.subject.meshOocytes - Cytology - Drug Effectsen_US
dc.subject.meshOogenesis - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshBeta-Endorphin - Pharmacologyen_US
dc.titleThe effect of β-endorphin on rat oocyte maturation in vitroen_US
dc.typeArticleen_US
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_US
dc.identifier.authorityO, WS=rp00315en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0303-7207(90)90191-Aen_US
dc.identifier.pmid2138100-
dc.identifier.scopuseid_2-s2.0-0025055339en_US
dc.identifier.volume68en_US
dc.identifier.issue2-3en_US
dc.identifier.spage181en_US
dc.identifier.epage185en_US
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridO, WS=6701729369en_US

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