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- Publisher Website: 10.1016/0303-7207(90)90191-A
- Scopus: eid_2-s2.0-0025055339
- PMID: 2138100
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Article: The effect of β-endorphin on rat oocyte maturation in vitro
Title | The effect of β-endorphin on rat oocyte maturation in vitro |
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Authors | |
Keywords | (Rat) Naloxone Oocyte maturation β-Endorphin |
Issue Date | 1990 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce |
Citation | Molecular And Cellular Endocrinology, 1990, v. 68 n. 2-3, p. 181-185 How to Cite? |
Abstract | Cumulus enclosed or denuded oocytes obtained from ovaries of 25- to 27-day Sprague-Dawley rats underwent spontaneous germinal vesicle breakdown (GVBD) when cultured for 6 h in Krebs-Ringer's buffered solution (KRBS). This spontaneous division was found to be inhibited by adding β-endorphin to the culture system and the inhibition was dose dependent, ranging from 200 to 800 pg/ml KRBS. Naloxone, a potent opioid antagonist without any agonistic action, did not stimulate spontaneous GVBD when added to the KRBS at doses ranging from 80 to 120 pg/ml. However, by adding 80 pg/ml naloxone to the culture system containing 600 pg/ml β-endorphin, the inhibitory effect of β-endorphin on spontaneous GVBD could be reversed completely. |
Persistent Identifier | http://hdl.handle.net/10722/149500 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.130 |
DC Field | Value | Language |
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dc.contributor.author | O, WS | en_US |
dc.date.accessioned | 2012-06-26T05:54:34Z | - |
dc.date.available | 2012-06-26T05:54:34Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Molecular And Cellular Endocrinology, 1990, v. 68 n. 2-3, p. 181-185 | en_US |
dc.identifier.issn | 0303-7207 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/149500 | - |
dc.description.abstract | Cumulus enclosed or denuded oocytes obtained from ovaries of 25- to 27-day Sprague-Dawley rats underwent spontaneous germinal vesicle breakdown (GVBD) when cultured for 6 h in Krebs-Ringer's buffered solution (KRBS). This spontaneous division was found to be inhibited by adding β-endorphin to the culture system and the inhibition was dose dependent, ranging from 200 to 800 pg/ml KRBS. Naloxone, a potent opioid antagonist without any agonistic action, did not stimulate spontaneous GVBD when added to the KRBS at doses ranging from 80 to 120 pg/ml. However, by adding 80 pg/ml naloxone to the culture system containing 600 pg/ml β-endorphin, the inhibitory effect of β-endorphin on spontaneous GVBD could be reversed completely. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce | en_US |
dc.relation.ispartof | Molecular and Cellular Endocrinology | en_US |
dc.subject | (Rat) | - |
dc.subject | Naloxone | - |
dc.subject | Oocyte maturation | - |
dc.subject | β-Endorphin | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Meiosis - Drug Effects | en_US |
dc.subject.mesh | Naloxone - Pharmacology | en_US |
dc.subject.mesh | Oocytes - Cytology - Drug Effects | en_US |
dc.subject.mesh | Oogenesis - Drug Effects | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Beta-Endorphin - Pharmacology | en_US |
dc.title | The effect of β-endorphin on rat oocyte maturation in vitro | en_US |
dc.type | Article | en_US |
dc.identifier.email | O, WS:owaisum@hkucc.hku.hk | en_US |
dc.identifier.authority | O, WS=rp00315 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0303-7207(90)90191-A | en_US |
dc.identifier.pmid | 2138100 | - |
dc.identifier.scopus | eid_2-s2.0-0025055339 | en_US |
dc.identifier.volume | 68 | en_US |
dc.identifier.issue | 2-3 | en_US |
dc.identifier.spage | 181 | en_US |
dc.identifier.epage | 185 | en_US |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | O, WS=6701729369 | en_US |
dc.identifier.issnl | 0303-7207 | - |