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Article: Structural changes of the guinea pig prostatic epithelial cells after gossypol treatment

TitleStructural changes of the guinea pig prostatic epithelial cells after gossypol treatment
Authors
Issue Date1989
Citation
Acta Anatomica, 1989, v. 134 n. 1, p. 18-25 How to Cite?
AbstractThe effect of gossypol acetic acid on the prostate gland of the guinea pig was assessed ultrastructurally. The three lobes of the gland showed differences in sensitivity and reacted differently to gossypol treatment. In the lateral prostate, there was a reduction in the profile of the granular endoplasmic reticulum and dense secretory granules with a concurrent appearance of smaller clear granules and an increase in cytoplasmic filamentous bundles. The latter feature was similar to that of the coagulating gland. In the dorsal prostate, the general reaction was similar to that in the lateral prostate except that there was no increase in filamentous content. In the coagulating gland, there was a reduction or total disappearance of apical secretory blebs and an increase in lysosomes, a feature not found in the lateral and dorsal lobes. Damages to mitochondria were observed in the dorsal prostate and coagulating gland but not in the lateral prostate. It is concluded that gossypol affects not only the testis, but also alters the structure and functions of the prostate gland.
Persistent Identifierhttp://hdl.handle.net/10722/149495
ISSN
2000 Impact Factor: 2.435
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_US
dc.contributor.authorTam, CCen_US
dc.date.accessioned2012-06-26T05:54:32Z-
dc.date.available2012-06-26T05:54:32Z-
dc.date.issued1989en_US
dc.identifier.citationActa Anatomica, 1989, v. 134 n. 1, p. 18-25en_US
dc.identifier.issn0001-5180en_US
dc.identifier.urihttp://hdl.handle.net/10722/149495-
dc.description.abstractThe effect of gossypol acetic acid on the prostate gland of the guinea pig was assessed ultrastructurally. The three lobes of the gland showed differences in sensitivity and reacted differently to gossypol treatment. In the lateral prostate, there was a reduction in the profile of the granular endoplasmic reticulum and dense secretory granules with a concurrent appearance of smaller clear granules and an increase in cytoplasmic filamentous bundles. The latter feature was similar to that of the coagulating gland. In the dorsal prostate, the general reaction was similar to that in the lateral prostate except that there was no increase in filamentous content. In the coagulating gland, there was a reduction or total disappearance of apical secretory blebs and an increase in lysosomes, a feature not found in the lateral and dorsal lobes. Damages to mitochondria were observed in the dorsal prostate and coagulating gland but not in the lateral prostate. It is concluded that gossypol affects not only the testis, but also alters the structure and functions of the prostate gland.en_US
dc.languageengen_US
dc.relation.ispartofActa Anatomicaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshEpithelium - Drug Effects - Ultrastructureen_US
dc.subject.meshGossypol - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshProstate - Cytology - Drug Effects - Ultrastructureen_US
dc.titleStructural changes of the guinea pig prostatic epithelial cells after gossypol treatmenten_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2718711-
dc.identifier.scopuseid_2-s2.0-0024592833en_US
dc.identifier.volume134en_US
dc.identifier.issue1en_US
dc.identifier.spage18en_US
dc.identifier.epage25en_US
dc.identifier.isiWOS:A1989U054300003-
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridTam, CC=7201442974en_US

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