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Article: Inhibin as an oocyte meiotic inhibitor

TitleInhibin as an oocyte meiotic inhibitor
Authors
O, WSRobertson, DMDe Kretser, DM
Keywords(Rat)
Activin
Follicle stimulating hormone suppressing protein
Inhibin
Maturation division
Ocyte
Issue Date1989
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce
Citation
Molecular And Cellular Endocrinology, 1989, v. 62 n. 2, p. 307-311 How to Cite?
DOI: http://dx.doi.org/10.1016/0303-7207(89)90018-X
AbstractThe effect of inhibin on oocyte maturation division was studied in vitro. Inhibin inhibited spontaneous division in both cumulus enclosed and denuded rat oocytes obtained from immature rats. The inhibition was dose-dependent (15-5000 units/ml) with an ED50 of 45.8 units/ml (4.00 nM). Follicle stimulating hormone (FSH) suppressing protein (FSP) which has inhibin-like activity accelerated the rate of meiotic maturation of rat oocytes in culture (P < 0.05, at a dose of 0.7 μg/ml) while activin, which has opposite biological effects to inhibin in many systems did not significantly stimulate oocyte maturation at a dose of 1.12 μg/ml. The actions of the three proteins studied were reversible.
Persistent Identifierhttp://hdl.handle.net/10722/149494
ISSN
0303-7207
2021 Impact Factor: 4.369
2020 SCImago Journal Rankings: 1.296

 

DC FieldValueLanguage
dc.contributor.authorO, WSen_US
dc.contributor.authorRobertson, DMen_US
dc.contributor.authorDe Kretser, DMen_US
dc.date.accessioned2012-06-26T05:54:30Z-
dc.date.available2012-06-26T05:54:30Z-
dc.date.issued1989en_US
dc.identifier.citationMolecular And Cellular Endocrinology, 1989, v. 62 n. 2, p. 307-311en_US
dc.identifier.issn0303-7207en_US
dc.identifier.urihttp://hdl.handle.net/10722/149494-
dc.description.abstractThe effect of inhibin on oocyte maturation division was studied in vitro. Inhibin inhibited spontaneous division in both cumulus enclosed and denuded rat oocytes obtained from immature rats. The inhibition was dose-dependent (15-5000 units/ml) with an ED50 of 45.8 units/ml (4.00 nM). Follicle stimulating hormone (FSH) suppressing protein (FSP) which has inhibin-like activity accelerated the rate of meiotic maturation of rat oocytes in culture (P < 0.05, at a dose of 0.7 μg/ml) while activin, which has opposite biological effects to inhibin in many systems did not significantly stimulate oocyte maturation at a dose of 1.12 μg/ml. The actions of the three proteins studied were reversible.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mceen_US
dc.relation.ispartofMolecular and Cellular Endocrinologyen_US
dc.subject(Rat)-
dc.subjectActivin-
dc.subjectFollicle stimulating hormone suppressing protein-
dc.subjectInhibin-
dc.subjectMaturation division-
dc.subjectOcyte-
dc.subject.meshActivinsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshInhibins - Pharmacologyen_US
dc.subject.meshMeiosis - Drug Effectsen_US
dc.subject.meshOocytes - Cytology - Drug Effectsen_US
dc.subject.meshPeptides - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleInhibin as an oocyte meiotic inhibitoren_US
dc.typeArticleen_US
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_US
dc.identifier.authorityO, WS=rp00315en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0303-7207(89)90018-X-
dc.identifier.pmid2744231-
dc.identifier.scopuseid_2-s2.0-0024553102en_US
dc.identifier.volume62en_US
dc.identifier.issue2en_US
dc.identifier.spage307en_US
dc.identifier.epage311en_US
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridO, WS=6701729369en_US
dc.identifier.scopusauthoridRobertson, DM=7402818550en_US
dc.identifier.scopusauthoridDe Kretser, DM=7102926573en_US
dc.identifier.issnl0303-7207-

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