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Article: De novo formation of axon-like processes from axotomized retinal ganglion cells which exhibit long distance growth in a peripheral nerve graft in adult hamsters

TitleDe novo formation of axon-like processes from axotomized retinal ganglion cells which exhibit long distance growth in a peripheral nerve graft in adult hamsters
Authors
Issue Date1989
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1989, v. 484 n. 1-2, p. 371-377 How to Cite?
AbstractDamaged axons in the central nervous system of the adult mammal can be stimulated to regenerate extensively into a peripheral nerve graft. It was generally believed that the new axonal sprouts which extend into the graft arose from the injured proximal axonal stumps. However, when the retinal ganglion cells of the adult hamster were axotomized by crushing the optic nerve and the proximal axonal stump was not in direct apposition to the graft, a new axon-like process could be seen to be emitted from either the cell soma or dendrite and extended in the graft for at least 1-2 cm. This axon-like process was distinct from the original injured axon which could still be seen to course towards the optic disc in the retina. Evidently, even a fully differentiated central nervous system neuron of the adult mammal retains a great degree of morphological plasticity so that if the original axon is discouraged to regrow after injury, other parts of the neuron can act as favourable sites for the sprouting of a new axon-like process.
Persistent Identifierhttp://hdl.handle.net/10722/149493
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCho, EYPen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2012-06-26T05:54:30Z-
dc.date.available2012-06-26T05:54:30Z-
dc.date.issued1989en_US
dc.identifier.citationBrain Research, 1989, v. 484 n. 1-2, p. 371-377en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/149493-
dc.description.abstractDamaged axons in the central nervous system of the adult mammal can be stimulated to regenerate extensively into a peripheral nerve graft. It was generally believed that the new axonal sprouts which extend into the graft arose from the injured proximal axonal stumps. However, when the retinal ganglion cells of the adult hamster were axotomized by crushing the optic nerve and the proximal axonal stump was not in direct apposition to the graft, a new axon-like process could be seen to be emitted from either the cell soma or dendrite and extended in the graft for at least 1-2 cm. This axon-like process was distinct from the original injured axon which could still be seen to course towards the optic disc in the retina. Evidently, even a fully differentiated central nervous system neuron of the adult mammal retains a great degree of morphological plasticity so that if the original axon is discouraged to regrow after injury, other parts of the neuron can act as favourable sites for the sprouting of a new axon-like process.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshOptic Nerve - Cytology - Physiologyen_US
dc.subject.meshPeripheral Nerves - Physiology - Transplantationen_US
dc.subject.meshRetina - Cytologyen_US
dc.subject.meshRetinal Ganglion Cells - Cytology - Physiologyen_US
dc.titleDe novo formation of axon-like processes from axotomized retinal ganglion cells which exhibit long distance growth in a peripheral nerve graft in adult hamstersen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2713695-
dc.identifier.scopuseid_2-s2.0-0024513624en_US
dc.identifier.volume484en_US
dc.identifier.issue1-2en_US
dc.identifier.spage371en_US
dc.identifier.epage377en_US
dc.identifier.isiWOS:A1989U226100042-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridCho, EYP=7202649985en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US

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