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Article: Mullerian inhibiting substance production and testicular migration and descent in the pouch young of a marsupial

TitleMullerian inhibiting substance production and testicular migration and descent in the pouch young of a marsupial
Authors
Issue Date1988
Citation
Development, 1988, v. 104 n. 4, p. 549-556 How to Cite?
AbstractThe ontogeny of Mullerian inhibiting substance (MIS) production by the developing testis of an Australian marsupial, the tammar wallaby (Macropus eugenii), was determined during pouch life using an organ-culture bioassay of mouse fetal urogenital ridge. This information was related to the morphological events during testicular migration and descent. MIS biological activity was found in testes (but not ovaries or liver) of pouch young from 2 to 85 days of age. MIS production had commenced by day 2, which is within a day of the first gross morphological signs of testicular differentiation. Mullerian duct regression occurred between 10 and 30 days, which partly coincided with testicular migration to the inguinal region and enlargement of the gubernacular bulb (15 to 30 days). These observations are consistent with the hypothesis that MIS may be involved in testicular transabdominal migration. The epididymis commenced development and growth only after the testis had descended through the inguinal ring. This provides no support for the suggestion that the epididymis is involved in testicular descent into the scrotum. The basic sequence of events in post-testicular sexual differentiation in the wallaby is sufficiently similar to that seen in eutherian mammals to make it an excellent experimental model for future studies to testicular differentiation, migration and descent.
Persistent Identifierhttp://hdl.handle.net/10722/149483
ISSN
2015 Impact Factor: 6.059
2015 SCImago Journal Rankings: 5.239
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHutson, JMen_US
dc.contributor.authorShaw, Gen_US
dc.contributor.authorO, WSen_US
dc.contributor.authorShort, RVen_US
dc.contributor.authorRenfree, MBen_US
dc.date.accessioned2012-06-26T05:54:16Z-
dc.date.available2012-06-26T05:54:16Z-
dc.date.issued1988en_US
dc.identifier.citationDevelopment, 1988, v. 104 n. 4, p. 549-556en_US
dc.identifier.issn0950-1991en_US
dc.identifier.urihttp://hdl.handle.net/10722/149483-
dc.description.abstractThe ontogeny of Mullerian inhibiting substance (MIS) production by the developing testis of an Australian marsupial, the tammar wallaby (Macropus eugenii), was determined during pouch life using an organ-culture bioassay of mouse fetal urogenital ridge. This information was related to the morphological events during testicular migration and descent. MIS biological activity was found in testes (but not ovaries or liver) of pouch young from 2 to 85 days of age. MIS production had commenced by day 2, which is within a day of the first gross morphological signs of testicular differentiation. Mullerian duct regression occurred between 10 and 30 days, which partly coincided with testicular migration to the inguinal region and enlargement of the gubernacular bulb (15 to 30 days). These observations are consistent with the hypothesis that MIS may be involved in testicular transabdominal migration. The epididymis commenced development and growth only after the testis had descended through the inguinal ring. This provides no support for the suggestion that the epididymis is involved in testicular descent into the scrotum. The basic sequence of events in post-testicular sexual differentiation in the wallaby is sufficiently similar to that seen in eutherian mammals to make it an excellent experimental model for future studies to testicular differentiation, migration and descent.en_US
dc.languageengen_US
dc.relation.ispartofDevelopmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Mullerian Hormoneen_US
dc.subject.meshGlycoproteinsen_US
dc.subject.meshGrowth Inhibitors - Biosynthesisen_US
dc.subject.meshMacropodidae - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMarsupialia - Physiologyen_US
dc.subject.meshMullerian Ductsen_US
dc.subject.meshSex Differentiationen_US
dc.subject.meshTesticular Hormonesen_US
dc.subject.meshTestis - Anatomy & Histology - Growth & Development - Metabolismen_US
dc.titleMullerian inhibiting substance production and testicular migration and descent in the pouch young of a marsupialen_US
dc.typeArticleen_US
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_US
dc.identifier.authorityO, WS=rp00315en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3268402-
dc.identifier.scopuseid_2-s2.0-0024164077en_US
dc.identifier.volume104en_US
dc.identifier.issue4en_US
dc.identifier.spage549en_US
dc.identifier.epage556en_US
dc.identifier.isiWOS:A1988R618300004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHutson, JM=7202643280en_US
dc.identifier.scopusauthoridShaw, G=7401773619en_US
dc.identifier.scopusauthoridO, WS=6701729369en_US
dc.identifier.scopusauthoridShort, RV=7202190995en_US
dc.identifier.scopusauthoridRenfree, MB=7005587252en_US

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