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Article: Scanning electron microscopic study of invasiveness between normal and neoplastic cells and fibroblasts in monolayer culture

TitleScanning electron microscopic study of invasiveness between normal and neoplastic cells and fibroblasts in monolayer culture
Authors
Issue Date1988
Citation
Anticancer Research, 1988, v. 8 n. 2, p. 275-280 How to Cite?
AbstractNormal cells are non-invasive except for a few cell types such as leukocytes and macrophages, while neoplastic cells are active in both migration and invasion. In the present investigation, the confrontations of normal rat hepatocytes, lung macrophages and B16 melanoma cells with monolayers of fibroblasts grown on collagen gel have been studied. When monolayers of fibroblasts were confronted with melanoma cells, there was obvious retraction of the fibroblasts. When hepatocytes or macrophages were seeded onto monolayers of fibroblasts, infiltration alway occurred at intercellular contacts and no retraction of fibroblasts was seen. Therefore it would appear that normal and neoplastic cells penetrate into monolayers of fibroblasts by different mechanisms.
Persistent Identifierhttp://hdl.handle.net/10722/149482
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChew, ECen_US
dc.contributor.authorMok, CHen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorLiu, WKen_US
dc.contributor.authorRiches, DJen_US
dc.date.accessioned2012-06-26T05:54:15Z-
dc.date.available2012-06-26T05:54:15Z-
dc.date.issued1988en_US
dc.identifier.citationAnticancer Research, 1988, v. 8 n. 2, p. 275-280en_US
dc.identifier.issn0250-7005en_US
dc.identifier.urihttp://hdl.handle.net/10722/149482-
dc.description.abstractNormal cells are non-invasive except for a few cell types such as leukocytes and macrophages, while neoplastic cells are active in both migration and invasion. In the present investigation, the confrontations of normal rat hepatocytes, lung macrophages and B16 melanoma cells with monolayers of fibroblasts grown on collagen gel have been studied. When monolayers of fibroblasts were confronted with melanoma cells, there was obvious retraction of the fibroblasts. When hepatocytes or macrophages were seeded onto monolayers of fibroblasts, infiltration alway occurred at intercellular contacts and no retraction of fibroblasts was seen. Therefore it would appear that normal and neoplastic cells penetrate into monolayers of fibroblasts by different mechanisms.en_US
dc.languageengen_US
dc.relation.ispartofAnticancer Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshFibroblasts - Ultrastructureen_US
dc.subject.meshMacrophages - Ultrastructureen_US
dc.subject.meshMelanomaen_US
dc.subject.meshMiceen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshNeoplasm Invasiveness - Ultrastructureen_US
dc.subject.meshPulmonary Alveoli - Cytologyen_US
dc.subject.meshRatsen_US
dc.titleScanning electron microscopic study of invasiveness between normal and neoplastic cells and fibroblasts in monolayer cultureen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3364938-
dc.identifier.scopuseid_2-s2.0-0023952033en_US
dc.identifier.volume8en_US
dc.identifier.issue2en_US
dc.identifier.spage275en_US
dc.identifier.epage280en_US
dc.identifier.isiWOS:A1988N140100011-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridChew, EC=7102013767en_US
dc.identifier.scopusauthoridMok, CH=7102344233en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridLiu, WK=13204573100en_US
dc.identifier.scopusauthoridRiches, DJ=7005837860en_US

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