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Article: Primary genetic control of somatic sexual differentiation in a mammal

TitlePrimary genetic control of somatic sexual differentiation in a mammal
Authors
Issue Date1988
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 1988, v. 331 n. 6158, p. 716-717 How to Cite?
AbstractThe classical view of mammalian sexual differentiation is that a gene on the Y chromosome transforms the indifferent gonad into a testis. The Leydig cells than secrete androgen which stimulates the development of the male reproductive tract, and the Sertoli cells secrete Mullerian inhibitory substance which inhibits the development of the female reproductive tract. In the absence of a testis, the Mullerian duct develops into the Fallopian tubes, uterua and vagina. Thus the whole of sexual differentiation is thought to be hormonally mediated as a consequence of this initial genetic determination of gonadal sex. We have found evidence in a marsupial mammal for extensive sexual dimorphisms which precede any morphological diffentiation of the gonads. Thus the classical view of mammalian sexual differentiation may have over-emphasized the role of testicular hormones, and overlooked earlier genetic effects.
Persistent Identifierhttp://hdl.handle.net/10722/149481
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorO, WSen_US
dc.contributor.authorShort, RVen_US
dc.contributor.authorRenfree, MBen_US
dc.contributor.authorShaw, Gen_US
dc.date.accessioned2012-06-26T05:54:14Z-
dc.date.available2012-06-26T05:54:14Z-
dc.date.issued1988en_US
dc.identifier.citationNature, 1988, v. 331 n. 6158, p. 716-717en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttp://hdl.handle.net/10722/149481-
dc.description.abstractThe classical view of mammalian sexual differentiation is that a gene on the Y chromosome transforms the indifferent gonad into a testis. The Leydig cells than secrete androgen which stimulates the development of the male reproductive tract, and the Sertoli cells secrete Mullerian inhibitory substance which inhibits the development of the female reproductive tract. In the absence of a testis, the Mullerian duct develops into the Fallopian tubes, uterua and vagina. Thus the whole of sexual differentiation is thought to be hormonally mediated as a consequence of this initial genetic determination of gonadal sex. We have found evidence in a marsupial mammal for extensive sexual dimorphisms which precede any morphological diffentiation of the gonads. Thus the classical view of mammalian sexual differentiation may have over-emphasized the role of testicular hormones, and overlooked earlier genetic effects.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_US
dc.relation.ispartofNatureen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshFemaleen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMacropodidae - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMarsupialia - Physiologyen_US
dc.subject.meshOvary - Cytologyen_US
dc.subject.meshSex Differentiationen_US
dc.subject.meshTestis - Cytologyen_US
dc.titlePrimary genetic control of somatic sexual differentiation in a mammalen_US
dc.typeArticleen_US
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_US
dc.identifier.authorityO, WS=rp00315en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3344046-
dc.identifier.scopuseid_2-s2.0-0023928772en_US
dc.identifier.volume331en_US
dc.identifier.issue6158en_US
dc.identifier.spage716en_US
dc.identifier.epage717en_US
dc.identifier.isiWOS:A1988M216000064-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridO, WS=6701729369en_US
dc.identifier.scopusauthoridShort, RV=7202190995en_US
dc.identifier.scopusauthoridRenfree, MB=7005587252en_US
dc.identifier.scopusauthoridShaw, G=7401773619en_US

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