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Article: A structural and cytochemical study of the effects of gossypol on the epithelial cells of the guinea-pig seminal vesicle

TitleA structural and cytochemical study of the effects of gossypol on the epithelial cells of the guinea-pig seminal vesicle
Authors
Issue Date1988
PublisherSociety for Reproduction and Fertility. The Journal's web site is located at http://www.journals-of-reproduction.org.uk
Citation
Journal Of Reproduction And Fertility, 1988, v. 84 n. 2, p. 659-668 How to Cite?
AbstractGossypol acetic acid, given to guinea-pigs at a concentration of 10 mg/kg daily for up to 7 weeks, exerted an inhibitory effect on the secretory activity of the glandular cells of the seminal vesicles. The diminished secretory function was associated with a decrease in thiamine pyrophosphatase (TPPase)(EC 3.6.1.6) activity in the luminal border and the Golgi cisternae. There was no increase in cytoplasmic filaments, and mitochondrial damage was not observed. The most striking effect was on the basal lamina, where the lamina densa increased significantly in thickness, while the lamina lucida decreased marginally in thickness. This was coupled with an increase in proteoglycan content on both sides of the lamina densa. It would appear that gossypol reduces the luminal secretory function on the one hand, while it increases the basal secretory activity on the other, thus modifying the structure of the basal lamina. The functional significance of these changes remains unknown
Persistent Identifierhttp://hdl.handle.net/10722/149479
ISSN
2002 Impact Factor: 2.865
2003 SCImago Journal Rankings: 0.665
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YCen_US
dc.contributor.authorTam, CCen_US
dc.date.accessioned2012-06-26T05:54:13Z-
dc.date.available2012-06-26T05:54:13Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Reproduction And Fertility, 1988, v. 84 n. 2, p. 659-668en_US
dc.identifier.issn0022-4251en_US
dc.identifier.urihttp://hdl.handle.net/10722/149479-
dc.description.abstractGossypol acetic acid, given to guinea-pigs at a concentration of 10 mg/kg daily for up to 7 weeks, exerted an inhibitory effect on the secretory activity of the glandular cells of the seminal vesicles. The diminished secretory function was associated with a decrease in thiamine pyrophosphatase (TPPase)(EC 3.6.1.6) activity in the luminal border and the Golgi cisternae. There was no increase in cytoplasmic filaments, and mitochondrial damage was not observed. The most striking effect was on the basal lamina, where the lamina densa increased significantly in thickness, while the lamina lucida decreased marginally in thickness. This was coupled with an increase in proteoglycan content on both sides of the lamina densa. It would appear that gossypol reduces the luminal secretory function on the one hand, while it increases the basal secretory activity on the other, thus modifying the structure of the basal lamina. The functional significance of these changes remains unknownen_US
dc.languageengen_US
dc.publisherSociety for Reproduction and Fertility. The Journal's web site is located at http://www.journals-of-reproduction.org.uken_US
dc.relation.ispartofJournal of Reproduction and Fertilityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEpithelium - Drug Effects - Ultrastructureen_US
dc.subject.meshGossypol - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshSeminal Vesicles - Drug Effects - Ultrastructureen_US
dc.titleA structural and cytochemical study of the effects of gossypol on the epithelial cells of the guinea-pig seminal vesicleen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid3199385-
dc.identifier.scopuseid_2-s2.0-0023794284en_US
dc.identifier.volume84en_US
dc.identifier.issue2en_US
dc.identifier.spage659en_US
dc.identifier.epage668en_US
dc.identifier.isiWOS:A1988Q861400034-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridTam, CC=7201442974en_US

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