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Article: Synaptic organization of the dorsal lateral geniculate nucleus in the adult hamster. An electron microscope study using degeneration and horseradish peroxidase tracing techniques

TitleSynaptic organization of the dorsal lateral geniculate nucleus in the adult hamster. An electron microscope study using degeneration and horseradish peroxidase tracing techniques
Authors
Issue Date1985
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htm
Citation
Anatomy And Embryology, 1985, v. 171 n. 2, p. 223-234 How to Cite?
AbstractThe synaptic organization of the α sector of the dorsal lateral geniculate nucleus has been examined by electron microscopy in normal adult hamsters and in adult hamsters subjected to unilateral eye enucleation or intravitreal injection of horseradish peroxidase. Two types of neuropil are apparent. Islands of complex neuropil partially enclosed by astrocyte processes (synaptic glomeruli) are surrounded by a sea of simpler non-glomerular neuropil. The latter is dominated by small axons terminals with spherical synaptic vesicles and Gray type 1 axodendritic contacts (SR-boutons) and also contains axon terminals with flattened synaptic vesicles (F-boutons). The glomerular neuropil contains (i) exclusively postsynaptic dendrites and dendrites protrusions of presumptive projection cells; (ii) pre- and postsynaptic pleomorphic-vesicle-containing P-boutons (interpreted as appendages of the dendrites of interneurons); (iii) large axon terminals containing spherical synaptic vesicles and large pale mitochondria (R-boutons) which were experimentally identified as retinal terminals and which are presynaptic to both projection cell dendrites and P-boutons at Gray type 1 contacts; (iv) F-boutons (minority component). F-boutons and P-boutons are presynaptic to both projection cell dendrites and P-boutons and P-boutons are the intermediate elements of various serial synapses including triplet (triadic) synapses. Medium-large terminals with spherical synaptic vesicles and dark mitochondria (RLD-boutons) which were commonly invaginated by dendritic spines of projection cells in small glomerulus-like formations were also identified. The origin of RLD-boutons is unknown but SR-boutons probably derive chiefly from ipsilateral visual cortex and possibly also from superior colliculus, and non-glomerular F-boutons probably originate in the ipsilateral thalamic reticular nucleus. No differences in synaptic organization were found between the part of the nucleus which receives uncrossed retinal input and the part which receives crossed input, nor were differences seen in the size, fine structure or relationships between the terminals of identified crossed and uncrossed retinal axons.
Persistent Identifierhttp://hdl.handle.net/10722/149460
ISSN
2008 Impact Factor: 1.39
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSo, KFen_US
dc.contributor.authorCampbell, Gen_US
dc.contributor.authorLieberman, ARen_US
dc.date.accessioned2012-06-26T05:54:04Z-
dc.date.available2012-06-26T05:54:04Z-
dc.date.issued1985en_US
dc.identifier.citationAnatomy And Embryology, 1985, v. 171 n. 2, p. 223-234en_US
dc.identifier.issn0340-2061en_US
dc.identifier.urihttp://hdl.handle.net/10722/149460-
dc.description.abstractThe synaptic organization of the α sector of the dorsal lateral geniculate nucleus has been examined by electron microscopy in normal adult hamsters and in adult hamsters subjected to unilateral eye enucleation or intravitreal injection of horseradish peroxidase. Two types of neuropil are apparent. Islands of complex neuropil partially enclosed by astrocyte processes (synaptic glomeruli) are surrounded by a sea of simpler non-glomerular neuropil. The latter is dominated by small axons terminals with spherical synaptic vesicles and Gray type 1 axodendritic contacts (SR-boutons) and also contains axon terminals with flattened synaptic vesicles (F-boutons). The glomerular neuropil contains (i) exclusively postsynaptic dendrites and dendrites protrusions of presumptive projection cells; (ii) pre- and postsynaptic pleomorphic-vesicle-containing P-boutons (interpreted as appendages of the dendrites of interneurons); (iii) large axon terminals containing spherical synaptic vesicles and large pale mitochondria (R-boutons) which were experimentally identified as retinal terminals and which are presynaptic to both projection cell dendrites and P-boutons at Gray type 1 contacts; (iv) F-boutons (minority component). F-boutons and P-boutons are presynaptic to both projection cell dendrites and P-boutons and P-boutons are the intermediate elements of various serial synapses including triplet (triadic) synapses. Medium-large terminals with spherical synaptic vesicles and dark mitochondria (RLD-boutons) which were commonly invaginated by dendritic spines of projection cells in small glomerulus-like formations were also identified. The origin of RLD-boutons is unknown but SR-boutons probably derive chiefly from ipsilateral visual cortex and possibly also from superior colliculus, and non-glomerular F-boutons probably originate in the ipsilateral thalamic reticular nucleus. No differences in synaptic organization were found between the part of the nucleus which receives uncrossed retinal input and the part which receives crossed input, nor were differences seen in the size, fine structure or relationships between the terminals of identified crossed and uncrossed retinal axons.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htmen_US
dc.relation.ispartofAnatomy and Embryologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinae - Anatomy & Histologyen_US
dc.subject.meshGeniculate Bodies - Ultrastructureen_US
dc.subject.meshHorseradish Peroxidase - Diagnostic Useen_US
dc.subject.meshInjectionsen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshNerve Degenerationen_US
dc.subject.meshNerve Endings - Ultrastructureen_US
dc.subject.meshNeurons - Ultrastructureen_US
dc.subject.meshRetina - Ultrastructureen_US
dc.subject.meshSynapses - Ultrastructureen_US
dc.subject.meshVitreous Bodyen_US
dc.titleSynaptic organization of the dorsal lateral geniculate nucleus in the adult hamster. An electron microscope study using degeneration and horseradish peroxidase tracing techniquesen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3985371-
dc.identifier.scopuseid_2-s2.0-0021946948en_US
dc.identifier.volume171en_US
dc.identifier.issue2en_US
dc.identifier.spage223en_US
dc.identifier.epage234en_US
dc.identifier.isiWOS:A1985AHJ9600011-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridCampbell, G=7401889253en_US
dc.identifier.scopusauthoridLieberman, AR=7202118609en_US

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