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- Publisher Website: 10.1038/bjc.1983.252
- Scopus: eid_2-s2.0-0021089530
- PMID: 6580033
- WOS: WOS:A1983RR07700010
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Article: Further observations on mechanisms of bone destruction by squamous carcinomas of the head and neck: The role of host stroma
Title | Further observations on mechanisms of bone destruction by squamous carcinomas of the head and neck: The role of host stroma |
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Authors | |
Issue Date | 1983 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc |
Citation | British Journal Of Cancer, 1983, v. 48 n. 5, p. 697-704 How to Cite? |
Abstract | Mechanisms of bone invasion by squamous carcinomas of the head and neck have been investigated using fresh tumours and established tumour cell lines in an in vitro bone resorption assay with 45Ca-labelled mouse calvaria. Fresh tumours regularly resorb bone in vitro. Activity is consistently reduced by indomethacin. The tumours release E 2 prostaglandins (PGE 2) in amounts sufficient to account for ~50% of the bone resorption observed. Small amounts of non-prostaglandin (indomethacin-resistant) osteolytic factors are also produced. Control non-neoplastic tissues show a variable capacity to resorb bone in vitro; PGE 2 levels in these tissues may be related to their content of inflammatory cells. Tumour cell lines also resorb bone in vitro but, for most lines, activity is not significantly blocked by indomethacin and PGE 2 levels are generally insufficient to account for the osteolysis observed. Non-prostaglandin bone resorbing factors thus predominate. It is concluded that most squamous cancers of the head and neck are osteolytic in vitro and release a mixture of prostaglandin and non-prostaglandin factors which stimulate osteoclastic bone resorption. These factors are derived from both neoplastic and stromal elements, and are 'tumour-associated' rather than 'tumour-specific'. In vitro bone resorption and prostaglandin release does not correlate with pathological features of the tumour or with post-operative survival. |
Persistent Identifier | http://hdl.handle.net/10722/149445 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 3.000 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tsao, SW | en_US |
dc.contributor.author | Burman, JF | en_US |
dc.contributor.author | Pittam, MR | en_US |
dc.contributor.author | Carter, RL | en_US |
dc.date.accessioned | 2012-06-26T05:53:43Z | - |
dc.date.available | 2012-06-26T05:53:43Z | - |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | British Journal Of Cancer, 1983, v. 48 n. 5, p. 697-704 | en_US |
dc.identifier.issn | 0007-0920 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/149445 | - |
dc.description.abstract | Mechanisms of bone invasion by squamous carcinomas of the head and neck have been investigated using fresh tumours and established tumour cell lines in an in vitro bone resorption assay with 45Ca-labelled mouse calvaria. Fresh tumours regularly resorb bone in vitro. Activity is consistently reduced by indomethacin. The tumours release E 2 prostaglandins (PGE 2) in amounts sufficient to account for ~50% of the bone resorption observed. Small amounts of non-prostaglandin (indomethacin-resistant) osteolytic factors are also produced. Control non-neoplastic tissues show a variable capacity to resorb bone in vitro; PGE 2 levels in these tissues may be related to their content of inflammatory cells. Tumour cell lines also resorb bone in vitro but, for most lines, activity is not significantly blocked by indomethacin and PGE 2 levels are generally insufficient to account for the osteolysis observed. Non-prostaglandin bone resorbing factors thus predominate. It is concluded that most squamous cancers of the head and neck are osteolytic in vitro and release a mixture of prostaglandin and non-prostaglandin factors which stimulate osteoclastic bone resorption. These factors are derived from both neoplastic and stromal elements, and are 'tumour-associated' rather than 'tumour-specific'. In vitro bone resorption and prostaglandin release does not correlate with pathological features of the tumour or with post-operative survival. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc | en_US |
dc.relation.ispartof | British Journal of Cancer | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bone Resorption - Drug Effects | en_US |
dc.subject.mesh | Carcinoma, Squamous Cell - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Culture Media | en_US |
dc.subject.mesh | Culture Techniques | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Dinoprostone | en_US |
dc.subject.mesh | Fibroblasts - Metabolism | en_US |
dc.subject.mesh | Head And Neck Neoplasms - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, Inbred Balb C | en_US |
dc.subject.mesh | Prostaglandins E - Metabolism | en_US |
dc.subject.mesh | Prostaglandins F - Metabolism | en_US |
dc.subject.mesh | Skin - Metabolism | en_US |
dc.title | Further observations on mechanisms of bone destruction by squamous carcinomas of the head and neck: The role of host stroma | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tsao, SW:gswtsao@hkucc.hku.hk | en_US |
dc.identifier.authority | Tsao, SW=rp00399 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/bjc.1983.252 | - |
dc.identifier.pmid | 6580033 | - |
dc.identifier.scopus | eid_2-s2.0-0021089530 | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 697 | en_US |
dc.identifier.epage | 704 | en_US |
dc.identifier.isi | WOS:A1983RR07700010 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_US |
dc.identifier.scopusauthorid | Burman, JF=16159916300 | en_US |
dc.identifier.scopusauthorid | Pittam, MR=6701621876 | en_US |
dc.identifier.scopusauthorid | Carter, RL=7402936927 | en_US |
dc.identifier.issnl | 0007-0920 | - |