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- Publisher Website: 10.1016/0002-9610(83)90229-5
- Scopus: eid_2-s2.0-0020521032
- PMID: 6578686
- WOS: WOS:A1983RM79400009
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Article: Patterns and mechanisms of bone invasion by squamous carcinomas of the head and neck
Title | Patterns and mechanisms of bone invasion by squamous carcinomas of the head and neck |
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Authors | |
Issue Date | 1983 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg |
Citation | American Journal Of Surgery, 1983, v. 146 n. 4, p. 451-455 How to Cite? |
Abstract | Patterns and mechanisms of local bone invasion by squamous carcinomas of the head and neck have been investigated. Detailed surgical pathology has shown that these tumors invade contiguous skeletal or metaplastic bone principally through an indirect process; the normal bone resorbing cells of the host (osteoclasts) are activated and erode bone in front of the advancing tumor edge. Tumor cells take over the destructive process when the osteoclast response has waned. These morphologic patterns have been reproduced in an in vitro model when calcium-45-labelled mouse calvaria, cocultured with a tumor for 3 days, are resorbed by osteoclasts. Freshly excised tumors, established tumor cell lines, and tumor xenografts release osteolysins in vitro which act as osteoclastic stimulants. They include both prostaglandins E 2 and F(2α), and nonprostaglandin factors, and are derived from tumor cells and from the associated host stroma. Virtually all the tumors examined released osteolysins and resorbed bone in vitro independent of their site, size, degree of differentiation, and the presence or absence of clinical bone invasion. |
Persistent Identifier | http://hdl.handle.net/10722/149440 |
ISSN | 2021 Impact Factor: 3.125 2020 SCImago Journal Rankings: 0.957 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Carter, RL | en_US |
dc.contributor.author | Tsao, SW | en_US |
dc.contributor.author | Burman, JF | en_US |
dc.date.accessioned | 2012-06-26T05:53:40Z | - |
dc.date.available | 2012-06-26T05:53:40Z | - |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | American Journal Of Surgery, 1983, v. 146 n. 4, p. 451-455 | en_US |
dc.identifier.issn | 0002-9610 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/149440 | - |
dc.description.abstract | Patterns and mechanisms of local bone invasion by squamous carcinomas of the head and neck have been investigated. Detailed surgical pathology has shown that these tumors invade contiguous skeletal or metaplastic bone principally through an indirect process; the normal bone resorbing cells of the host (osteoclasts) are activated and erode bone in front of the advancing tumor edge. Tumor cells take over the destructive process when the osteoclast response has waned. These morphologic patterns have been reproduced in an in vitro model when calcium-45-labelled mouse calvaria, cocultured with a tumor for 3 days, are resorbed by osteoclasts. Freshly excised tumors, established tumor cell lines, and tumor xenografts release osteolysins in vitro which act as osteoclastic stimulants. They include both prostaglandins E 2 and F(2α), and nonprostaglandin factors, and are derived from tumor cells and from the associated host stroma. Virtually all the tumors examined released osteolysins and resorbed bone in vitro independent of their site, size, degree of differentiation, and the presence or absence of clinical bone invasion. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg | en_US |
dc.relation.ispartof | American Journal of Surgery | en_US |
dc.subject.mesh | Bone Neoplasms - Etiology - Pathology - Secondary | en_US |
dc.subject.mesh | Calcium - Metabolism | en_US |
dc.subject.mesh | Carcinoma, Squamous Cell - Metabolism - Pathology | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Cells, Cultured | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Dinoprostone | en_US |
dc.subject.mesh | Head And Neck Neoplasms - Metabolism - Pathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Laryngeal Neoplasms - Pathology | en_US |
dc.subject.mesh | Osteolysis - Metabolism - Pathology | en_US |
dc.subject.mesh | Prostaglandins E - Metabolism | en_US |
dc.subject.mesh | Prostaglandins F - Metabolism | en_US |
dc.title | Patterns and mechanisms of bone invasion by squamous carcinomas of the head and neck | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tsao, SW:gswtsao@hkucc.hku.hk | en_US |
dc.identifier.authority | Tsao, SW=rp00399 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0002-9610(83)90229-5 | - |
dc.identifier.pmid | 6578686 | - |
dc.identifier.scopus | eid_2-s2.0-0020521032 | en_US |
dc.identifier.volume | 146 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 451 | en_US |
dc.identifier.epage | 455 | en_US |
dc.identifier.isi | WOS:A1983RM79400009 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Carter, RL=7402936927 | en_US |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_US |
dc.identifier.scopusauthorid | Burman, JF=16159916300 | en_US |
dc.identifier.issnl | 0002-9610 | - |