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Article: Patterns and mechanisms of bone invasion by squamous carcinomas of the head and neck

TitlePatterns and mechanisms of bone invasion by squamous carcinomas of the head and neck
Authors
Issue Date1983
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
American Journal Of Surgery, 1983, v. 146 n. 4, p. 451-455 How to Cite?
AbstractPatterns and mechanisms of local bone invasion by squamous carcinomas of the head and neck have been investigated. Detailed surgical pathology has shown that these tumors invade contiguous skeletal or metaplastic bone principally through an indirect process; the normal bone resorbing cells of the host (osteoclasts) are activated and erode bone in front of the advancing tumor edge. Tumor cells take over the destructive process when the osteoclast response has waned. These morphologic patterns have been reproduced in an in vitro model when calcium-45-labelled mouse calvaria, cocultured with a tumor for 3 days, are resorbed by osteoclasts. Freshly excised tumors, established tumor cell lines, and tumor xenografts release osteolysins in vitro which act as osteoclastic stimulants. They include both prostaglandins E 2 and F(2α), and nonprostaglandin factors, and are derived from tumor cells and from the associated host stroma. Virtually all the tumors examined released osteolysins and resorbed bone in vitro independent of their site, size, degree of differentiation, and the presence or absence of clinical bone invasion.
Persistent Identifierhttp://hdl.handle.net/10722/149440
ISSN
2015 Impact Factor: 2.403
2015 SCImago Journal Rankings: 1.286
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCarter, RLen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorBurman, JFen_US
dc.date.accessioned2012-06-26T05:53:40Z-
dc.date.available2012-06-26T05:53:40Z-
dc.date.issued1983en_US
dc.identifier.citationAmerican Journal Of Surgery, 1983, v. 146 n. 4, p. 451-455en_US
dc.identifier.issn0002-9610en_US
dc.identifier.urihttp://hdl.handle.net/10722/149440-
dc.description.abstractPatterns and mechanisms of local bone invasion by squamous carcinomas of the head and neck have been investigated. Detailed surgical pathology has shown that these tumors invade contiguous skeletal or metaplastic bone principally through an indirect process; the normal bone resorbing cells of the host (osteoclasts) are activated and erode bone in front of the advancing tumor edge. Tumor cells take over the destructive process when the osteoclast response has waned. These morphologic patterns have been reproduced in an in vitro model when calcium-45-labelled mouse calvaria, cocultured with a tumor for 3 days, are resorbed by osteoclasts. Freshly excised tumors, established tumor cell lines, and tumor xenografts release osteolysins in vitro which act as osteoclastic stimulants. They include both prostaglandins E 2 and F(2α), and nonprostaglandin factors, and are derived from tumor cells and from the associated host stroma. Virtually all the tumors examined released osteolysins and resorbed bone in vitro independent of their site, size, degree of differentiation, and the presence or absence of clinical bone invasion.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurgen_US
dc.relation.ispartofAmerican Journal of Surgeryen_US
dc.subject.meshBone Neoplasms - Etiology - Pathology - Secondaryen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCarcinoma, Squamous Cell - Metabolism - Pathologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDinoprosten_US
dc.subject.meshDinoprostoneen_US
dc.subject.meshHead And Neck Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLaryngeal Neoplasms - Pathologyen_US
dc.subject.meshOsteolysis - Metabolism - Pathologyen_US
dc.subject.meshProstaglandins E - Metabolismen_US
dc.subject.meshProstaglandins F - Metabolismen_US
dc.titlePatterns and mechanisms of bone invasion by squamous carcinomas of the head and necken_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6578686-
dc.identifier.scopuseid_2-s2.0-0020521032en_US
dc.identifier.volume146en_US
dc.identifier.issue4en_US
dc.identifier.spage451en_US
dc.identifier.epage455en_US
dc.identifier.isiWOS:A1983RM79400009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCarter, RL=7402936927en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridBurman, JF=16159916300en_US

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