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Article: Retinotectal map formation in dually innervated tecta: a regneration study in Xenopus with one compound eye following bilateral optic nerve section

TitleRetinotectal map formation in dually innervated tecta: a regneration study in Xenopus with one compound eye following bilateral optic nerve section
Authors
Issue Date1982
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248
Citation
Journal Of Comparative Neurology, 1982, v. 206 n. 2, p. 119-130 How to Cite?
AbstractRetinotectal map formation was studied during regeneration in young adult Xenopus. Right compound double-temporal eyes (TT) were formed in tailbud stage embryos by the fusion of two temporal halves of the eye blastema in the same orbit. In other animals right compound double-nasal eyes (NN) were prepared. In both combinations the left eye was kept intact. After metamorphosis the right and left optic nerves were sectioned to induce optic fiber regeneration from each eye to both tecta. The patterns of retinotectal projections from the compound and normal eyes were studied from 37 to 364 days after optic nerve section, using electrophysiological recording of the visuotectal projections and 3H-proline autoradiographic assay from one of the two eyes. The left normal eyes projected in a retinotopic fashion, across the entire extent of the right and left dually innervated tecta. In contrast, the right compound eye projections were confined to the rostrolateral or to the caudomedial part of the right and left tecta in TT and NN animals, respectively. These tectal areas corresponded to the termination of temporal and nasal hemiretinal fibers of the normal eye. Discontinuous, interdigitating projection patterns from the right and left eyes were found in parts of the tecta where the compound and the normal eye projections overlapped. These results indicate that the normal optic fiber projections caused the originally expanded compound eye projections to be restricted to the corresponding part of the dually innervated tecta. It is suggested that the orderliness and the extent of the retinotectal map are established by the competition and interaction of optic fibers based on stable positional programming of the retinal ganglion cells.
Persistent Identifierhttp://hdl.handle.net/10722/149436
ISSN
2015 Impact Factor: 3.331
2015 SCImago Journal Rankings: 2.345
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStraznicky, Cen_US
dc.contributor.authorTay, Den_US
dc.date.accessioned2012-06-26T05:53:38Z-
dc.date.available2012-06-26T05:53:38Z-
dc.date.issued1982en_US
dc.identifier.citationJournal Of Comparative Neurology, 1982, v. 206 n. 2, p. 119-130en_US
dc.identifier.issn0021-9967en_US
dc.identifier.urihttp://hdl.handle.net/10722/149436-
dc.description.abstractRetinotectal map formation was studied during regeneration in young adult Xenopus. Right compound double-temporal eyes (TT) were formed in tailbud stage embryos by the fusion of two temporal halves of the eye blastema in the same orbit. In other animals right compound double-nasal eyes (NN) were prepared. In both combinations the left eye was kept intact. After metamorphosis the right and left optic nerves were sectioned to induce optic fiber regeneration from each eye to both tecta. The patterns of retinotectal projections from the compound and normal eyes were studied from 37 to 364 days after optic nerve section, using electrophysiological recording of the visuotectal projections and 3H-proline autoradiographic assay from one of the two eyes. The left normal eyes projected in a retinotopic fashion, across the entire extent of the right and left dually innervated tecta. In contrast, the right compound eye projections were confined to the rostrolateral or to the caudomedial part of the right and left tecta in TT and NN animals, respectively. These tectal areas corresponded to the termination of temporal and nasal hemiretinal fibers of the normal eye. Discontinuous, interdigitating projection patterns from the right and left eyes were found in parts of the tecta where the compound and the normal eye projections overlapped. These results indicate that the normal optic fiber projections caused the originally expanded compound eye projections to be restricted to the corresponding part of the dually innervated tecta. It is suggested that the orderliness and the extent of the retinotectal map are established by the competition and interaction of optic fibers based on stable positional programming of the retinal ganglion cells.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248en_US
dc.relation.ispartofJournal of Comparative Neurologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshOptic Nerve - Physiologyen_US
dc.subject.meshRetina - Anatomy & Histology - Physiologyen_US
dc.subject.meshSuperior Colliculi - Anatomy & Histology - Physiologyen_US
dc.subject.meshVisual Pathways - Anatomy & Histology - Physiologyen_US
dc.subject.meshXenopusen_US
dc.titleRetinotectal map formation in dually innervated tecta: a regneration study in Xenopus with one compound eye following bilateral optic nerve sectionen_US
dc.typeArticleen_US
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_US
dc.identifier.authorityTay, D=rp00336en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7085924-
dc.identifier.scopuseid_2-s2.0-0020085489en_US
dc.identifier.volume206en_US
dc.identifier.issue2en_US
dc.identifier.spage119en_US
dc.identifier.epage130en_US
dc.identifier.isiWOS:A1982NN13200002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridStraznicky, C=7004293883en_US
dc.identifier.scopusauthoridTay, D=7006796825en_US

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