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Article: The development of the diencephalon in Xenopus. An autoradiographic study

TitleThe development of the diencephalon in Xenopus. An autoradiographic study
Authors
Issue Date1982
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htm
Citation
Anatomy And Embryology, 1982, v. 163 n. 4, p. 371-388 How to Cite?
AbstractThe development of the diencephalon and the time of origin of neurons of thalamic nuclei were determined in Xenopus with 3H-thymidine autoradiography. Isotope was administered into embryos, tadpoles and metamorphic animals and sacrificed after survival time between 24 hours and 5 months. The position and the number of heavily labeled cells, corresponding to terminal mitoses at the time of isotope injection were established on transverse and sagittal sections of the frog brain. Neurons in the diencephalon were distributed in a spatiotemporal manner such that cells generated earliest were located in the caudo-ventro-lateral portion of the diencephalon followed in a rostro-dorso-medial sequence by cells formed at later stages. The waves of cell generation resulted in three apparent developmental gradients in the caudo-rostral, latero-medial and in the ventro-dorsal directions in the diencephalon. Consequently neurons generated latest were found in the rotro-dorso-medial portion of the diencephalon. The overall rostro-dorso-medial diencephalic growth and the spatiotemporal generation of its neurons are the reverse of the tectal growth and cell generation reported in Xenopus which occurs in a rostrolateral to caudomedial direction. The findings of the present observations appear to indicate that the mirror-image reversal of the retinotectal and retinodiencephalic projections along the temporo-nasal retinal axis is the consequence of the divergent growth of the diencephalon and the tectum from the common embryonic di-mesencephalic junction. These observations furthermore suggest that the orientation of the retinal maps is ensured by the differential maturity gradients in the tectum and diencephalon, respectively, presumably expressed in molecular terms.
Persistent Identifierhttp://hdl.handle.net/10722/149434
ISSN
2008 Impact Factor: 1.39
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTay, Den_US
dc.contributor.authorStraznicky, Cen_US
dc.date.accessioned2012-06-26T05:53:36Z-
dc.date.available2012-06-26T05:53:36Z-
dc.date.issued1982en_US
dc.identifier.citationAnatomy And Embryology, 1982, v. 163 n. 4, p. 371-388en_US
dc.identifier.issn0340-2061en_US
dc.identifier.urihttp://hdl.handle.net/10722/149434-
dc.description.abstractThe development of the diencephalon and the time of origin of neurons of thalamic nuclei were determined in Xenopus with 3H-thymidine autoradiography. Isotope was administered into embryos, tadpoles and metamorphic animals and sacrificed after survival time between 24 hours and 5 months. The position and the number of heavily labeled cells, corresponding to terminal mitoses at the time of isotope injection were established on transverse and sagittal sections of the frog brain. Neurons in the diencephalon were distributed in a spatiotemporal manner such that cells generated earliest were located in the caudo-ventro-lateral portion of the diencephalon followed in a rostro-dorso-medial sequence by cells formed at later stages. The waves of cell generation resulted in three apparent developmental gradients in the caudo-rostral, latero-medial and in the ventro-dorsal directions in the diencephalon. Consequently neurons generated latest were found in the rotro-dorso-medial portion of the diencephalon. The overall rostro-dorso-medial diencephalic growth and the spatiotemporal generation of its neurons are the reverse of the tectal growth and cell generation reported in Xenopus which occurs in a rostrolateral to caudomedial direction. The findings of the present observations appear to indicate that the mirror-image reversal of the retinotectal and retinodiencephalic projections along the temporo-nasal retinal axis is the consequence of the divergent growth of the diencephalon and the tectum from the common embryonic di-mesencephalic junction. These observations furthermore suggest that the orientation of the retinal maps is ensured by the differential maturity gradients in the tectum and diencephalon, respectively, presumably expressed in molecular terms.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htmen_US
dc.relation.ispartofAnatomy and Embryologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAutoradiographyen_US
dc.subject.meshDiencephalon - Anatomy & Histology - Embryology - Growth & Developmenten_US
dc.subject.meshMetamorphosis, Biologicalen_US
dc.subject.meshNeuronsen_US
dc.subject.meshThalamic Nuclei - Embryologyen_US
dc.subject.meshThymidineen_US
dc.subject.meshTritium - Diagnostic Useen_US
dc.subject.meshXenopus Laevis - Embryologyen_US
dc.titleThe development of the diencephalon in Xenopus. An autoradiographic studyen_US
dc.typeArticleen_US
dc.identifier.emailTay, D:dkctay@hkucc.hku.hken_US
dc.identifier.authorityTay, D=rp00336en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7091706-
dc.identifier.scopuseid_2-s2.0-0020042361en_US
dc.identifier.volume163en_US
dc.identifier.issue4en_US
dc.identifier.spage371en_US
dc.identifier.epage388en_US
dc.identifier.isiWOS:A1982NH62800002-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridTay, D=7006796825en_US
dc.identifier.scopusauthoridStraznicky, C=7004293883en_US

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